| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/16734800 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in LXR-623 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PALM3 | paralemmin 3 | 1.1 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.9 |
| ROGDI | rogdi homolog (Drosophila) | 0.68 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | 0.6 |
| MEX3C | mex-3 RNA binding family member C | 0.55 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.54 |
| PML | promyelocytic leukemia | 0.51 |
| AMOT | angiomotin | 0.44 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.43 |
| GRK6 | G protein-coupled receptor kinase 6 | 0.42 |
| SLC38A2 | solute carrier family 38, member 2 | 0.41 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.41 |
| ZBTB17 | zinc finger and BTB domain containing 17 | 0.4 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | 0.39 |
| TMEM51 | transmembrane protein 51 | 0.38 |
| NGFR | nerve growth factor receptor | 0.38 |
| ZNF175 | zinc finger protein 175 | 0.37 |
| TLE5 | TLE family member 5, transcriptional modulator | 0.37 |
| EVI5 | ecotropic viral integration site 5 | 0.36 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.36 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.35 |
| CLIC3 | chloride intracellular channel 3 | 0.35 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.34 |
| IL6ST | interleukin 6 signal transducer | 0.34 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.33 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.32 |
| NME3 | NME/NM23 nucleoside diphosphate kinase 3 | 0.32 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.31 |
| TMEM98 | transmembrane protein 98 | 0.3 |
| ZFP30 | ZFP30 zinc finger protein | 0.3 |
| GEM | GTP binding protein overexpressed in skeletal muscle | 0.3 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | 0.3 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.29 |
| CYBRD1 | cytochrome b reductase 1 | 0.29 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.28 |
| MT-ATP6 | ATP synthase F0 subunit 6 | 0.28 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.28 |
| BAIAP3 | BAI1-associated protein 3 | 0.28 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.28 |
| ABHD2 | abhydrolase domain containing 2 | 0.28 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | 0.28 |
| IFT22 | intraflagellar transport 22 | 0.28 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.28 |
| NOP10 | NOP10 ribonucleoprotein | 0.27 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.27 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.27 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.27 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 0.27 |
| GLS | glutaminase | 0.27 |
| ZNF174 | zinc finger protein 174 | 0.27 |
| GGA2 | golgi-associated, gamma adaptin ear containing, ARF binding protein 2 | 0.27 |
| NOVA2 | neuro-oncological ventral antigen 2 | 0.27 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | 0.27 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.27 |
| EPN3 | epsin 3 | 0.27 |
| CTTNBP2 | cortactin binding protein 2 | 0.26 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.26 |
| LYST | lysosomal trafficking regulator | 0.26 |
| ZNF740 | zinc finger protein 740 | 0.25 |
| IFNGR1 | interferon gamma receptor 1 | 0.25 |
| MYRF | myelin regulatory factor | 0.25 |
| PDLIM5 | PDZ and LIM domain 5 | 0.25 |
| ESAM | endothelial cell adhesion molecule | 0.25 |
| BHMT | betaine--homocysteine S-methyltransferase | 0.25 |
| MRPS24 | mitochondrial ribosomal protein S24 | 0.25 |
| ABHD3 | abhydrolase domain containing 3 | 0.24 |
| SRSF8 | serine/arginine-rich splicing factor 8 | 0.24 |
| SMAD3 | SMAD family member 3 | 0.24 |
| ANAPC11 | anaphase promoting complex subunit 11 | 0.24 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.24 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.24 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.24 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.24 |
| SLC25A29 | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 | 0.24 |
| MIDN | midnolin | 0.24 |
| SMO | smoothened, frizzled class receptor | 0.24 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.23 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 0.23 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | 0.23 |
| FOXP4 | forkhead box P4 | 0.23 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.23 |
| TMEM135 | transmembrane protein 135 | 0.23 |
| MPZL2 | myelin protein zero-like 2 | 0.23 |
| SUMO1 | small ubiquitin-like modifier 1 | 0.23 |
| DCHS1 | dachsous cadherin-related 1 | 0.23 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.23 |
| SYNPO | synaptopodin | 0.23 |
| PCDH1 | protocadherin 1 | 0.22 |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | 0.22 |
| TAF8 | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa | 0.22 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.22 |
| CDA | cytidine deaminase | 0.22 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | 0.22 |
| TMPO | thymopoietin | 0.22 |
| MOCS1 | molybdenum cofactor synthesis 1 | 0.22 |
| SQLE | squalene epoxidase | 0.22 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | 0.21 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.21 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.21 |
| DAP | death-associated protein | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLIN2 | perilipin 2 | -0.82 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.72 |
| IFI30 | interferon, gamma-inducible protein 30 | -0.7 |
| PEX7 | peroxisomal biogenesis factor 7 | -0.68 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.67 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.64 |
| RNF111 | ring finger protein 111 | -0.64 |
| ZBED9 | zinc finger, BED-type containing 9 | -0.61 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.6 |
| RGN | regucalcin | -0.57 |
| STK19 | serine/threonine kinase 19 | -0.57 |
| VGF | VGF nerve growth factor inducible | -0.56 |
| SLC25A39 | solute carrier family 25, member 39 | -0.56 |
| FGB | fibrinogen beta chain | -0.55 |
| CEP104 | centrosomal protein 104kDa | -0.55 |
| MYPOP | Myb-related transcription factor, partner of profilin | -0.55 |
| INAVA | innate immunity activator | -0.55 |
| TAPT1 | transmembrane anterior posterior transformation 1 | -0.53 |
| C9ORF40 | chromosome 9 open reading frame 40 | -0.53 |
| SESN2 | sestrin 2 | -0.52 |
| TMEM64 | transmembrane protein 64 | -0.52 |
| ATP23 | ATP23 metallopeptidase and ATP synthase assembly factor homolog | -0.5 |
| SESN1 | sestrin 1 | -0.48 |
| ZNF12 | zinc finger protein 12 | -0.46 |
| PNPLA2 | patatin-like phospholipase domain containing 2 | -0.44 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.44 |
| ZNF623 | zinc finger protein 623 | -0.44 |
| ELK1 | ELK1, member of ETS oncogene family | -0.43 |
| MGMT | O-6-methylguanine-DNA methyltransferase | -0.43 |
| ZNF263 | zinc finger protein 263 | -0.42 |
| COQ4 | coenzyme Q4 | -0.42 |
| TRIB3 | tribbles pseudokinase 3 | -0.42 |
| S100A14 | S100 calcium binding protein A14 | -0.41 |
| RAB30 | RAB30, member RAS oncogene family | -0.41 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | -0.4 |
| STC2 | stanniocalcin 2 | -0.39 |
| PROS1 | protein S (alpha) | -0.38 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | -0.38 |
| AMACR | alpha-methylacyl-CoA racemase | -0.38 |
| BORCS5 | BLOC-1 related complex subunit 5 | -0.38 |
| HELQ | helicase, POLQ-like | -0.37 |
| IPP | intracisternal A particle-promoted polypeptide | -0.37 |
| SLC2A4RG | SLC2A4 regulator | -0.37 |
| PSEN2 | presenilin 2 | -0.36 |
| SPTB | spectrin, beta, erythrocytic | -0.35 |
| B9D1 | B9 protein domain 1 | -0.35 |
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | -0.35 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | -0.35 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.35 |
| ZNF2 | zinc finger protein 2 | -0.35 |
| SLC12A8 | solute carrier family 12, member 8 | -0.34 |
| CXCL16 | chemokine (C-X-C motif) ligand 16 | -0.34 |
| TSPAN4 | tetraspanin 4 | -0.34 |
| COQ2 | coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | -0.34 |
| TMEM143 | transmembrane protein 143 | -0.34 |
| PPCDC | phosphopantothenoylcysteine decarboxylase | -0.34 |
| MROH6 | maestro heat-like repeat family member 6 | -0.34 |
| CEP72 | centrosomal protein 72kDa | -0.33 |
| BAIAP2 | BAI1-associated protein 2 | -0.33 |
| SH2D5 | SH2 domain containing 5 | -0.33 |
| FABP6 | fatty acid binding protein 6, ileal | -0.33 |
| UBL7 | ubiquitin-like 7 | -0.33 |
| ZNF33A | zinc finger protein 33A | -0.33 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | -0.33 |
| TMC4 | transmembrane channel-like 4 | -0.32 |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide | -0.32 |
| MID2 | midline 2 | -0.32 |
| ATF6B | activating transcription factor 6 beta | -0.32 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.31 |
| RNF130 | ring finger protein 130 | -0.31 |
| DZIP3 | DAZ interacting zinc finger protein 3 | -0.31 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | -0.31 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.31 |
| PLSCR1 | phospholipid scramblase 1 | -0.3 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | -0.3 |
| MYO18B | myosin XVIIIB | -0.3 |
| CNTLN | centlein, centrosomal protein | -0.3 |
| NRP1 | neuropilin 1 | -0.3 |
| RTL6 | retrotransposon Gag like 6 | -0.3 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.3 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | -0.3 |
| KIF27 | kinesin family member 27 | -0.3 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.3 |
| PMF1 | polyamine-modulated factor 1 | -0.3 |
| JUN | jun proto-oncogene | -0.3 |
| DPP4 | dipeptidyl-peptidase 4 | -0.3 |
| MOCS2 | molybdenum cofactor synthesis 2 | -0.29 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.29 |
| ZNF675 | zinc finger protein 675 | -0.29 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.29 |
| FNIP1 | folliculin interacting protein 1 | -0.29 |
| SELENOF | selenoprotein F | -0.29 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.29 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.28 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.28 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.28 |
| UPP1 | uridine phosphorylase 1 | -0.28 |
| SLC25A52 | solute carrier family 25, member 52 | -0.28 |
| HOXB9 | homeobox B9 | -0.28 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | -0.28 |
