| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.247562 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.216523 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.20771 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.136235 |
| S100A10 | S100 calcium binding protein A10 | 0.121765 |
| NAV1 | neuron navigator 1 | 0.113643 |
| VIM | vimentin | 0.109558 |
| CD44 | CD44 molecule (Indian blood group) | 0.103164 |
| LDHA | lactate dehydrogenase A | 0.100983 |
| ANXA2 | annexin A2 | 0.0974602 |
| LOX | lysyl oxidase | 0.0970007 |
| MAP1B | microtubule-associated protein 1B | 0.0969364 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0897014 |
| FBN1 | fibrillin 1 | 0.0860844 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0825139 |
| AHNAK | AHNAK nucleoprotein | 0.0717926 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0715805 |
| PLAT | plasminogen activator, tissue | 0.0710022 |
| GLIS3 | GLIS family zinc finger 3 | 0.0700587 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0688468 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0625721 |
| MX2 | MX dynamin-like GTPase 2 | 0.060122 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0597227 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0595741 |
| HDAC9 | histone deacetylase 9 | 0.0594613 |
| DST | dystonin | 0.059296 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0591074 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.057169 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0570208 |
| COL5A2 | collagen, type V, alpha 2 | 0.0562849 |
| MYADM | myeloid-associated differentiation marker | 0.0560219 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0546888 |
| COL3A1 | collagen, type III, alpha 1 | 0.0534733 |
| SP100 | SP100 nuclear antigen | 0.0528945 |
| PGK1 | phosphoglycerate kinase 1 | 0.0513819 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0508753 |
| B2M | beta-2-microglobulin | 0.0492931 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0489071 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0484461 |
| RNF213 | ring finger protein 213 | 0.0483333 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0477045 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0474728 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0468042 |
| MT2A | metallothionein 2A | 0.0459199 |
| SON | SON DNA binding protein | 0.045372 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0440374 |
| UBC | ubiquitin C | 0.0437426 |
| COL1A2 | collagen, type I, alpha 2 | 0.0432983 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0425131 |
| ASPH | aspartate beta-hydroxylase | 0.0414376 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.041016 |
| VCL | vinculin | 0.0410142 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0409708 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0404564 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0403175 |
| CDK6 | cyclin-dependent kinase 6 | 0.0401625 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0393855 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0393636 |
| FSTL1 | follistatin-like 1 | 0.0389547 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0388576 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0378787 |
| AUTS2 | autism susceptibility candidate 2 | 0.037658 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0375024 |
| PODXL | podocalyxin-like | 0.0373959 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0365585 |
| JMJD1C | jumonji domain containing 1C | 0.0364851 |
| NEK7 | NIMA-related kinase 7 | 0.0357337 |
| PKM | pyruvate kinase, muscle | 0.0356595 |
| TMSB4X | thymosin beta 4, X-linked | 0.0353805 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0353633 |
| CAVIN1 | caveolae associated protein 1 | 0.0353603 |
| LOXL2 | lysyl oxidase-like 2 | 0.0347978 |
| FRMD5 | FERM domain containing 5 | 0.034775 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0345436 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0339289 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0335177 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.033373 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.033122 |
| BPTF | bromodomain PHD finger transcription factor | 0.0330198 |
| FRMD4A | FERM domain containing 4A | 0.03272 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0325603 |
| FLNA | filamin A, alpha | 0.0325469 |
| EHBP1 | EH domain binding protein 1 | 0.0324315 |
| TAGLN2 | transgelin 2 | 0.0323446 |
| THBS2 | thrombospondin 2 | 0.0322415 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0308747 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0308039 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0301013 |
| APP | amyloid beta (A4) precursor protein | 0.029984 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0296382 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0295828 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0294042 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0291052 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0287791 |
| CD99 | CD99 molecule | 0.0284415 |
| RASAL2 | RAS protein activator like 2 | 0.0283854 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0282743 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0282592 |
| ANXA1 | annexin A1 | 0.0282388 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0281586 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.0912294 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0821485 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0742805 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.065653 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0577093 |
| PTMA | prothymosin, alpha | -0.0567265 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0476332 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0446853 |
| MSI2 | musashi RNA-binding protein 2 | -0.0405368 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0376256 |
| CD109 | CD109 molecule | -0.0361988 |
| ADM | adrenomedullin | -0.0343671 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.0337965 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0328261 |
| RPL37A | ribosomal protein L37a | -0.0324322 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0311551 |
| SPAG9 | sperm associated antigen 9 | -0.0283515 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.027858 |
| GOLGA4 | golgin A4 | -0.0276009 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0271914 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | -0.0270347 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0269916 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0266931 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0263 |
| FAM107B | family with sequence similarity 107, member B | -0.0258801 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0257981 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0255362 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0254044 |
| FN1 | fibronectin 1 | -0.0253509 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0247433 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0243282 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0238066 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0235296 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0234243 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0234044 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0233624 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.023256 |
| HELZ | helicase with zinc finger | -0.0228522 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | -0.0216328 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.021459 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.0212411 |
| SLC38A1 | solute carrier family 38, member 1 | -0.021214 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.021103 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0209214 |
| INSIG1 | insulin induced gene 1 | -0.0205935 |
| INSIG2 | insulin induced gene 2 | -0.0193945 |
| FOSL1 | FOS-like antigen 1 | -0.0193511 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0191711 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0191675 |
| VEGFA | vascular endothelial growth factor A | -0.0190973 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0190112 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0187628 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.018761 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0185235 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0184782 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0183836 |
| RNF24 | ring finger protein 24 | -0.0183817 |
| RPLP2 | ribosomal protein, large, P2 | -0.0181448 |
| C1ORF21 | chromosome 1 open reading frame 21 | -0.0176733 |
| NGLY1 | N-glycanase 1 | -0.0175829 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0172411 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0171231 |
| TGFB1 | transforming growth factor, beta 1 | -0.0170665 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0165071 |
| RPL35A | ribosomal protein L35a | -0.0164672 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0163004 |
| MTCL1 | microtubule crosslinking factor 1 | -0.0161095 |
| TBC1D12 | TBC1 domain family, member 12 | -0.0159974 |
| IL7R | interleukin 7 receptor | -0.0158109 |
| DTNA | dystrobrevin, alpha | -0.0156777 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.0155212 |
| SUCO | SUN domain containing ossification factor | -0.0155043 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0153326 |
| RPL38 | ribosomal protein L38 | -0.0151022 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0147772 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0147437 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0146325 |
| DCLK2 | doublecortin-like kinase 2 | -0.0145583 |
| CMIP | c-Maf inducing protein | -0.0145448 |
| ABI1 | abl-interactor 1 | -0.0145181 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0143523 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0143168 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0142711 |
| PFDN2 | prefoldin subunit 2 | -0.014239 |
| FNBP1L | formin binding protein 1-like | -0.0141788 |
| GDF15 | growth differentiation factor 15 | -0.014129 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0141014 |
| MMP12 | matrix metallopeptidase 12 | -0.0140982 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0140306 |
| CTBP2 | C-terminal binding protein 2 | -0.0139816 |
| GLRX | glutaredoxin (thioltransferase) | -0.0139534 |
| SH3GL3 | SH3-domain GRB2-like 3 | -0.0139023 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | -0.0138896 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0138657 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | -0.0138564 |
| RPS2 | ribosomal protein S2 | -0.0138031 |
| USP3 | ubiquitin specific peptidase 3 | -0.0137216 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0136972 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0136753 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0135231 |
