| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.242425 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.231729 |
| AREG | amphiregulin | 0.218015 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.172939 |
| VIM | vimentin | 0.122452 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.109815 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.103362 |
| YAP1 | Yes-associated protein 1 | 0.102963 |
| MMP12 | matrix metallopeptidase 12 | 0.100471 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.100118 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0953489 |
| JMJD1C | jumonji domain containing 1C | 0.080834 |
| HMGA2 | high mobility group AT-hook 2 | 0.0793212 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0764613 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0718117 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0692783 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0633136 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0624588 |
| VMP1 | vacuole membrane protein 1 | 0.061148 |
| LDHA | lactate dehydrogenase A | 0.0569534 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.05678 |
| PCBP2 | poly(rC) binding protein 2 | 0.0566539 |
| ANXA1 | annexin A1 | 0.0561994 |
| MED13L | mediator complex subunit 13-like | 0.0559888 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0559678 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0554515 |
| TPI1 | triosephosphate isomerase 1 | 0.0544731 |
| DST | dystonin | 0.0542192 |
| USP34 | ubiquitin specific peptidase 34 | 0.0507431 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0494312 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.048092 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0476201 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0474164 |
| UBC | ubiquitin C | 0.0469835 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0461431 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.045985 |
| BRD2 | bromodomain containing 2 | 0.0459718 |
| RTN4 | reticulon 4 | 0.0457328 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0450734 |
| POTEF | POTE ankyrin domain family, member F | 0.0442095 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.043612 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.043501 |
| CCNL1 | cyclin L1 | 0.0434184 |
| EHBP1 | EH domain binding protein 1 | 0.0420912 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0418599 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0411533 |
| IPO7 | importin 7 | 0.0410146 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0400265 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0394485 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0392499 |
| TPM3 | tropomyosin 3 | 0.0389301 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0388455 |
| PCM1 | pericentriolar material 1 | 0.0387925 |
| TENM3 | teneurin transmembrane protein 3 | 0.0386174 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0384889 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0376877 |
| TBK1 | TANK-binding kinase 1 | 0.0370365 |
| ASPH | aspartate beta-hydroxylase | 0.0367758 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.036559 |
| TXNRD1 | thioredoxin reductase 1 | 0.0361378 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0345076 |
| XPOT | exportin, tRNA | 0.034396 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0342816 |
| PFN1 | profilin 1 | 0.0338578 |
| LDHB | lactate dehydrogenase B | 0.0336983 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0336901 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0329965 |
| CLTC | clathrin, heavy chain (Hc) | 0.0325681 |
| HDAC9 | histone deacetylase 9 | 0.0325582 |
| RAB10 | RAB10, member RAS oncogene family | 0.0325041 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.032485 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0321114 |
| RPL3 | ribosomal protein L3 | 0.0317028 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0315198 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0310427 |
| INTS6 | integrator complex subunit 6 | 0.030964 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0308327 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0305154 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.030423 |
| KDM5A | lysine (K)-specific demethylase 5A | 0.0302939 |
| EPHA6 | EPH receptor A6 | 0.0294356 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0291212 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0290639 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0290239 |
| MCL1 | myeloid cell leukemia 1 | 0.0289845 |
| HMGA1 | high mobility group AT-hook 1 | 0.0285899 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0285479 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0284918 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0284887 |
| CPOX | coproporphyrinogen oxidase | 0.0282617 |
| SETD5 | SET domain containing 5 | 0.028203 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0278555 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0275478 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.027215 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0271012 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0269862 |
| MGAT4C | MGAT4 family, member C | 0.0268733 |
| S100A6 | S100 calcium binding protein A6 | 0.0266381 |
| EPHA5 | EPH receptor A5 | 0.0265003 |
| ADIPOR2 | adiponectin receptor 2 | 0.0264052 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.168604 |
| PTMA | prothymosin, alpha | -0.0751702 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0609918 |
| RPS24 | ribosomal protein S24 | -0.0576711 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0551437 |
| RPL38 | ribosomal protein L38 | -0.0540829 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0500452 |
| NLGN1 | neuroligin 1 | -0.0493688 |
| RPLP1 | ribosomal protein, large, P1 | -0.0473941 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0472704 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0464729 |
| RPS29 | ribosomal protein S29 | -0.0464697 |
| CLDN1 | claudin 1 | -0.0460526 |
| AHNAK | AHNAK nucleoprotein | -0.0459787 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0410349 |
| RPL31 | ribosomal protein L31 | -0.0409022 |
| RPS19 | ribosomal protein S19 | -0.0381905 |
| RPL35A | ribosomal protein L35a | -0.0380604 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0380464 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0364817 |
| RPS27A | ribosomal protein S27a | -0.0361907 |
| RPL36 | ribosomal protein L36 | -0.0341141 |
| RPL26 | ribosomal protein L26 | -0.0335429 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0334354 |
| RPS21 | ribosomal protein S21 | -0.0333893 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0331305 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.031974 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0294611 |
| RPL34 | ribosomal protein L34 | -0.0291534 |
| LMO7 | LIM domain 7 | -0.028808 |
| RPLP2 | ribosomal protein, large, P2 | -0.0285177 |
| RPL37 | ribosomal protein L37 | -0.0282161 |
| RPS23 | ribosomal protein S23 | -0.0280135 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0274041 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0267213 |
| RAD21 | RAD21 homolog (S. pombe) | -0.026489 |
| RPS3 | ribosomal protein S3 | -0.0263977 |
| KLF6 | Kruppel-like factor 6 | -0.0261259 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0256823 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0255829 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0255394 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0251427 |
| FOXK2 | forkhead box K2 | -0.0247477 |
| HMGB2 | high mobility group box 2 | -0.0245023 |
| BRCA1 | breast cancer 1, early onset | -0.0238779 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0235077 |
| FUS | FUS RNA binding protein | -0.0234279 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0227029 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0224637 |
| RPL6 | ribosomal protein L6 | -0.0222862 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.021786 |
| RPL9 | ribosomal protein L9 | -0.0217292 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0214745 |
| RPS16 | ribosomal protein S16 | -0.0213754 |
| RPL36A | ribosomal protein L36a | -0.0212135 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.0209571 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.020839 |
| MKI67 | marker of proliferation Ki-67 | -0.0207525 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0206515 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0205401 |
| RPS25 | ribosomal protein S25 | -0.0199207 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | -0.0198945 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0198773 |
| EZR | ezrin | -0.0197667 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.019133 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0188196 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0185574 |
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | -0.0185532 |
| CENPE | centromere protein E, 312kDa | -0.0183269 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0182878 |
| NDC80 | NDC80 kinetochore complex component | -0.0180147 |
| RPL37A | ribosomal protein L37a | -0.017981 |
| NPR2 | natriuretic peptide receptor 2 | -0.0179095 |
| PARK7 | parkinson protein 7 | -0.0177134 |
| PRR11 | proline rich 11 | -0.0176061 |
| XPO7 | exportin 7 | -0.0171356 |
| SYT1 | synaptotagmin I | -0.0171021 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0169429 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0166587 |
| SRP72 | signal recognition particle 72kDa | -0.0165823 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0162639 |
| HDLBP | high density lipoprotein binding protein | -0.0161347 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0160778 |
| JPT2 | Jupiter microtubule associated homolog 2 | -0.0158283 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0157557 |
| TEAD4 | TEA domain family member 4 | -0.0156843 |
| TIMMDC1 | translocase of inner mitochondrial membrane domain containing 1 | -0.0156766 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0156339 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0155036 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | -0.0154695 |
| MATR3 | matrin 3 | -0.0154025 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.0152886 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0152718 |
| PRXL2A | peroxiredoxin like 2A | -0.015261 |
| PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | -0.0151413 |
| R3HDM1 | R3H domain containing 1 | -0.0151276 |
| ZNF33A | zinc finger protein 33A | -0.0150817 |
| ABI2 | abl-interactor 2 | -0.0150538 |
| RASAL2 | RAS protein activator like 2 | -0.0149728 |
| S100A9 | S100 calcium binding protein A9 | -0.0149382 |
