LY-2584702 (tosylate salt)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY-2584702 (tosylate salt) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY-2584702 (tosylate salt)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.126037
EXT1 exostosin glycosyltransferase 1 0.0670756
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0627564
ASPH aspartate beta-hydroxylase 0.0618658
B2M beta-2-microglobulin 0.0545457
CD44 CD44 molecule (Indian blood group) 0.0471066
FTL ferritin, light polypeptide 0.0467812
TMSB10 thymosin beta 10 0.0459373
ZSWIM6 zinc finger, SWIM-type containing 6 0.0436012
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0427413
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0385877
MT2A metallothionein 2A 0.0360836
TPT1 tumor protein, translationally-controlled 1 0.0342782
VCL vinculin 0.0327161
NAV2 neuron navigator 2 0.032357
PDLIM5 PDZ and LIM domain 5 0.0321271
RPL23 ribosomal protein L23 0.0304695
MYH9 myosin, heavy chain 9, non-muscle 0.0304035
HLA-B major histocompatibility complex, class I, B 0.0302379
PDE4D phosphodiesterase 4D, cAMP-specific 0.0282932
SP100 SP100 nuclear antigen 0.0276584
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0273176
INTS6 integrator complex subunit 6 0.0266908
RPS8 ribosomal protein S8 0.026481
RPL37A ribosomal protein L37a 0.0264772
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026353
RPS19 ribosomal protein S19 0.0252501
KYNU kynureninase 0.0251797
RPL31 ribosomal protein L31 0.0244239
RPL12 ribosomal protein L12 0.0241634
RNF213 ring finger protein 213 0.0237303
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0234516
MX1 MX dynamin-like GTPase 1 0.0230273
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0227939
UBC ubiquitin C 0.0227794
HDAC9 histone deacetylase 9 0.022453
IFI44L interferon-induced protein 44-like 0.0223275
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0222096
TFPI2 tissue factor pathway inhibitor 2 0.0220072
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0218763
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.02121
RPL19 ribosomal protein L19 0.020687
RPS27A ribosomal protein S27a 0.0205208
RPS20 ribosomal protein S20 0.0204773
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0204478
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0204432
OSMR oncostatin M receptor 0.0204073
GPC6 glypican 6 0.0202417
APOL1 apolipoprotein L, 1 0.0202141
S100A10 S100 calcium binding protein A10 0.0200845
CREB5 cAMP responsive element binding protein 5 0.0200499
RPL7 ribosomal protein L7 0.0199009
RPL26 ribosomal protein L26 0.0197852
RPS17 ribosomal protein S17 0.019654
SMAD3 SMAD family member 3 0.0191842
RPS13 ribosomal protein S13 0.0191643
MCL1 myeloid cell leukemia 1 0.0190116
SAMD4A sterile alpha motif domain containing 4A 0.0189167
RPS12 ribosomal protein S12 0.0188885
RIGI RNA sensor RIG-I 0.0185202
RPLP1 ribosomal protein, large, P1 0.0185114
ALCAM activated leukocyte cell adhesion molecule 0.0185107
AHNAK AHNAK nucleoprotein 0.0180513
RPLP2 ribosomal protein, large, P2 0.0179691
VIM vimentin 0.0178781
IFITM3 interferon induced transmembrane protein 3 0.0178677
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0178495
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.01776
RPL37 ribosomal protein L37 0.0175248
MYO1E myosin IE 0.0175095
SFTPA2 surfactant protein A2 0.017359
RPL28 ribosomal protein L28 0.0173194
LOXL2 lysyl oxidase-like 2 0.0169967
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0168377
EGFR epidermal growth factor receptor 0.0164736
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0163871
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0162994
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0160695
IFI6 interferon, alpha-inducible protein 6 0.0159999
SHB Src homology 2 domain containing adaptor protein B 0.0156026
RPL34 ribosomal protein L34 0.0155743
LGALS1 lectin, galactoside-binding, soluble, 1 0.0154207
RPS23 ribosomal protein S23 0.0153151
CRY1 cryptochrome circadian clock 1 0.0151596
SOD2 superoxide dismutase 2, mitochondrial 0.0150613
RPL9 ribosomal protein L9 0.0149698
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0147536
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0147087
HLA-A major histocompatibility complex, class I, A 0.0146271
RPL35 ribosomal protein L35 0.0145351
RPS4X ribosomal protein S4, X-linked 0.0144406
CA12 carbonic anhydrase XII 0.0143149
GOLGB1 golgin B1 0.0142662
RPL36 ribosomal protein L36 0.014194
DOCK5 dedicator of cytokinesis 5 0.0140302
EIF1 eukaryotic translation initiation factor 1 0.0138589
HLA-C major histocompatibility complex, class I, C 0.013765
RPL38 ribosomal protein L38 0.0136484
RPL35A ribosomal protein L35a 0.013638
RPS6 ribosomal protein S6 0.0135108

decreased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0645474
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0540806
POTEF POTE ankyrin domain family, member F -0.0513401
GLS2 glutaminase 2 (liver, mitochondrial) -0.0443555
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0421718
NAMPT nicotinamide phosphoribosyltransferase -0.0415541
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0403815
PTBP3 polypyrimidine tract binding protein 3 -0.0385975
ATP13A3 ATPase type 13A3 -0.0369666
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0359531
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0305103
BIRC6 baculoviral IAP repeat containing 6 -0.0294355
KMT2C lysine (K)-specific methyltransferase 2C -0.0291725
SRPK2 SRSF protein kinase 2 -0.0285032
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0280439
WDR43 WD repeat domain 43 -0.0268324
SBF2 SET binding factor 2 -0.0266575
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0261321
PRRC2C proline-rich coiled-coil 2C -0.0256494
GARS1 glycyl-tRNA synthetase 1 -0.025379
UGCG UDP-glucose ceramide glucosyltransferase -0.024525
ADAM10 ADAM metallopeptidase domain 10 -0.0244354
TXNRD1 thioredoxin reductase 1 -0.0242184
TTC3 tetratricopeptide repeat domain 3 -0.0241108
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.023833
DLG1 discs, large homolog 1 (Drosophila) -0.0236034
PLK2 polo-like kinase 2 -0.023526
VCAM1 vascular cell adhesion molecule 1 -0.0233172
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0231312
SPAG9 sperm associated antigen 9 -0.0223041
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0222701
STOM stomatin -0.0221216
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0219999
SCFD2 sec1 family domain containing 2 -0.0217657
GOLGA4 golgin A4 -0.0217495
USP3 ubiquitin specific peptidase 3 -0.0216375
PRRC1 proline-rich coiled-coil 1 -0.0214068
EML4 echinoderm microtubule associated protein like 4 -0.0209901
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0207541
MARCHF6 membrane associated ring-CH-type finger 6 -0.0203647
ACBD3 acyl-CoA binding domain containing 3 -0.0202878
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0201943
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0201782
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0199193
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0199056
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0198938
WAC WW domain containing adaptor with coiled-coil -0.0196176
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0195863
QKI QKI, KH domain containing, RNA binding -0.019542
KLHDC10 kelch domain containing 10 -0.0193297
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0191686
ANKRD10 ankyrin repeat domain 10 -0.0190912
RIC1 RAB6A GEF complex partner 1 -0.0190415
KMT2E lysine (K)-specific methyltransferase 2E -0.0189589
IARS1 isoleucyl-tRNA synthetase 1 -0.0188905
GDF15 growth differentiation factor 15 -0.0186741
NPEPPS aminopeptidase puromycin sensitive -0.0186604
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0185563
PTMA prothymosin, alpha -0.0184282
CELF1 CUGBP, Elav-like family member 1 -0.018334
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0182615
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0181018
NOP58 NOP58 ribonucleoprotein -0.0180024
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0179022
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0178898
CDK13 cyclin-dependent kinase 13 -0.0177886
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0177649
THOC2 THO complex 2 -0.0176859
CCNL1 cyclin L1 -0.0176841
FRMD4A FERM domain containing 4A -0.0176327
PFN1 profilin 1 -0.0175079
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0175059
RAP1B RAP1B, member of RAS oncogene family -0.0174542
MTDH metadherin -0.0174317
CSF1 colony stimulating factor 1 (macrophage) -0.0173689
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0172462
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0170461
RBM39 RNA binding motif protein 39 -0.0170186
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0170118
HELZ helicase with zinc finger -0.0168926
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.016886
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0168653
ZFAND3 zinc finger, AN1-type domain 3 -0.0165457
LITAF lipopolysaccharide-induced TNF factor -0.016462
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0164399
TOP2A topoisomerase (DNA) II alpha 170kDa -0.016361
ANAPC5 anaphase promoting complex subunit 5 -0.0163239
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0162987
SKAP2 src kinase associated phosphoprotein 2 -0.0162571
ANKRD17 ankyrin repeat domain 17 -0.0160076
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0159479
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0159405
MAP1B microtubule-associated protein 1B -0.0158536
ANKRD11 ankyrin repeat domain 11 -0.0157833
AFTPH aftiphilin -0.0157651
NAP1L4 nucleosome assembly protein 1-like 4 -0.015752
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0157351
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0155752
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0154924
XPO1 exportin 1 -0.01539