LY-2584702 (tosylate salt)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY-2584702 (tosylate salt) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY-2584702 (tosylate salt)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.229892
VIM vimentin 0.162613
IGFBP3 insulin-like growth factor binding protein 3 0.128248
FTL ferritin, light polypeptide 0.114172
TMSB10 thymosin beta 10 0.0949802
ACTG1 actin gamma 1 0.0903976
LDHA lactate dehydrogenase A 0.0832951
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0832725
AKAP12 A kinase (PRKA) anchor protein 12 0.0798341
RPS6 ribosomal protein S6 0.0724075
RPS19 ribosomal protein S19 0.0723623
EIF1 eukaryotic translation initiation factor 1 0.0713273
CA12 carbonic anhydrase XII 0.0691962
MT2A metallothionein 2A 0.0690705
ANXA2 annexin A2 0.0630666
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.056127
PKM pyruvate kinase, muscle 0.0531525
RPS16 ribosomal protein S16 0.0528369
KRT81 keratin 81, type II 0.05273
RPS8 ribosomal protein S8 0.0515583
RPL23 ribosomal protein L23 0.0499833
UBC ubiquitin C 0.0486114
IGFBP4 insulin-like growth factor binding protein 4 0.0441691
S100A10 S100 calcium binding protein A10 0.0438976
RPS3 ribosomal protein S3 0.0432457
RPL12 ribosomal protein L12 0.042652
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.041624
ALCAM activated leukocyte cell adhesion molecule 0.0410273
TPT1 tumor protein, translationally-controlled 1 0.0402147
RPL19 ribosomal protein L19 0.0382211
RPLP1 ribosomal protein, large, P1 0.0379693
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0374395
RPS13 ribosomal protein S13 0.03719
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0368412
RPLP0 ribosomal protein, large, P0 0.0363513
RPL8 ribosomal protein L8 0.036336
ENO1 enolase 1, (alpha) 0.036288
S100A6 S100 calcium binding protein A6 0.0360492
RPS17 ribosomal protein S17 0.0360354
PDE4D phosphodiesterase 4D, cAMP-specific 0.0353175
RACK1 receptor for activated C kinase 1 0.0352711
NAP1L1 nucleosome assembly protein 1-like 1 0.0350658
RPL26 ribosomal protein L26 0.033871
PFN1 profilin 1 0.033064
RPL13A ribosomal protein L13a 0.0327621
RPL7 ribosomal protein L7 0.0327081
DSTN destrin (actin depolymerizing factor) 0.0326341
RPL7A ribosomal protein L7a 0.0318425
TPI1 triosephosphate isomerase 1 0.0317332
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0316403
EIF4A1 eukaryotic translation initiation factor 4A1 0.0316375
RPL28 ribosomal protein L28 0.0305889
BTG1 B-cell translocation gene 1, anti-proliferative 0.0305814
PTMA prothymosin, alpha 0.030423
PGK1 phosphoglycerate kinase 1 0.0300447
EGFR epidermal growth factor receptor 0.0300116
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0295648
ASTN2 astrotactin 2 0.0295194
EXT1 exostosin glycosyltransferase 1 0.0288507
RPS5 ribosomal protein S5 0.0287598
RPS27A ribosomal protein S27a 0.0284791
RPL37A ribosomal protein L37a 0.0280867
RPS23 ribosomal protein S23 0.0278619
B2M beta-2-microglobulin 0.0276303
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0274258
RNF213 ring finger protein 213 0.027408
KTN1 kinectin 1 (kinesin receptor) 0.0273677
PRRC2C proline-rich coiled-coil 2C 0.0272757
RPLP2 ribosomal protein, large, P2 0.0272558
RPL32 ribosomal protein L32 0.0270622
LMNA lamin A/C 0.0269252
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0268231
ASPH aspartate beta-hydroxylase 0.0266621
RPS24 ribosomal protein S24 0.0262711
RPS14 ribosomal protein S14 0.0262443
NDRG1 N-myc downstream regulated 1 0.0261897
RPL31 ribosomal protein L31 0.0260462
KRT7 keratin 7, type II 0.0258402
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0252413
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0252337
SP100 SP100 nuclear antigen 0.0248885
RPS4X ribosomal protein S4, X-linked 0.0247124
RPL18 ribosomal protein L18 0.0244844
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0244243
NACA nascent polypeptide-associated complex alpha subunit 0.0242065
FAM107B family with sequence similarity 107, member B 0.0238935
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.023754
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0234237
BASP1 brain abundant, membrane attached signal protein 1 0.023276
SRRM2 serine/arginine repetitive matrix 2 0.0230526
EEF2 eukaryotic translation elongation factor 2 0.0226469
RPS27 ribosomal protein S27 0.0223314
MYADM myeloid-associated differentiation marker 0.0223304
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0220073
MYO1E myosin IE 0.0217462
EEF1G eukaryotic translation elongation factor 1 gamma 0.0217115
RPL11 ribosomal protein L11 0.0215766
RPS11 ribosomal protein S11 0.0215025
RPL37 ribosomal protein L37 0.0213598
RPL15 ribosomal protein L15 0.0211478

decreased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0180873
NAMPT nicotinamide phosphoribosyltransferase -0.01731
PDE10A phosphodiesterase 10A -0.0150205
DGKD diacylglycerol kinase, delta 130kDa -0.0142539
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0105176
KLF7 Kruppel-like factor 7 (ubiquitous) -0.01017
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.00968928
CEP95 centrosomal protein 95kDa -0.00960084
GPRIN3 GPRIN family member 3 -0.00912659
NRIP1 nuclear receptor interacting protein 1 -0.00802443
SMAD3 SMAD family member 3 -0.00775598
USP3 ubiquitin specific peptidase 3 -0.00740811
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.00739301
VCL vinculin -0.00732667
CYTH1 cytohesin 1 -0.00707091
ELL2 elongation factor, RNA polymerase II, 2 -0.00704994
AGFG1 ArfGAP with FG repeats 1 -0.00704081
ZMYM2 zinc finger, MYM-type 2 -0.00703613
MAPK8 mitogen-activated protein kinase 8 -0.00684813
KDM3A lysine (K)-specific demethylase 3A -0.00669257
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.00668665
ABI2 abl-interactor 2 -0.00652679
OSMR oncostatin M receptor -0.00651186
ARL5B ADP-ribosylation factor-like 5B -0.00632851
BRWD3 bromodomain and WD repeat domain containing 3 -0.00629044
NUP58 nucleoporin 58 -0.00623592
SPAG9 sperm associated antigen 9 -0.0061629
NAV2 neuron navigator 2 -0.0060755
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.00604255
CASC3 cancer susceptibility candidate 3 -0.00592163
USP37 ubiquitin specific peptidase 37 -0.0059071
NPC1 Niemann-Pick disease, type C1 -0.00571406
NCOA7 nuclear receptor coactivator 7 -0.00548164
TENT4A terminal nucleotidyltransferase 4A -0.00547561
ANLN anillin, actin binding protein -0.00534312
UBA6 ubiquitin-like modifier activating enzyme 6 -0.00532126
SNX14 sorting nexin 14 -0.00526393
EIF4H eukaryotic translation initiation factor 4H -0.00525729
RIN2 Ras and Rab interactor 2 -0.00525524
AFDN afadin, adherens junction formation factor -0.00513817
DMXL2 Dmx-like 2 -0.00511753
GRAMD1B GRAM domain containing 1B -0.00507618
CCL5 chemokine (C-C motif) ligand 5 -0.00504806
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -0.00498876
CDK19 cyclin-dependent kinase 19 -0.00498452
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.00491318
ATP13A3 ATPase type 13A3 -0.00486704
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.00484431
H1-4 H1.4 linker histone, cluster member -0.00484419
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.00478228
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 -0.00477765
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.00470292
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -0.00467007
PRPF39 pre-mRNA processing factor 39 -0.0046289
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.00459406
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.00458898
HEATR5B HEAT repeat containing 5B -0.0045884
ERRFI1 ERBB receptor feedback inhibitor 1 -0.00455531
ATXN10 ataxin 10 -0.00452252
BARD1 BRCA1 associated RING domain 1 -0.00450703
MARCHF6 membrane associated ring-CH-type finger 6 -0.00449573
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.00444478
NEK7 NIMA-related kinase 7 -0.00439873
MACROD2 MACRO domain containing 2 -0.00439581
CDK17 cyclin-dependent kinase 17 -0.00439489
ARRDC3 arrestin domain containing 3 -0.0043766
PANK2 pantothenate kinase 2 -0.00437082
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.00430624
UBQLN1 ubiquilin 1 -0.00424819
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.00422341
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -0.00419326
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.0041696
CHD1 chromodomain helicase DNA binding protein 1 -0.00415515
ZC3H11A zinc finger CCCH-type containing 11A -0.00414651
EVA1C eva-1 homolog C (C. elegans) -0.00413318
NUP153 nucleoporin 153kDa -0.00409998
ATG5 autophagy related 5 -0.00403722
MYH10 myosin, heavy chain 10, non-muscle -0.00402909
WDR33 WD repeat domain 33 -0.0040281
FANCL Fanconi anemia, complementation group L -0.00398672
BCL2L1 BCL2-like 1 -0.00396777
EMSY EMSY transcriptional repressor, BRCA2 interacting -0.00395932
PRELID2 PRELI domain containing 2 -0.00394605
SIN3A SIN3 transcription regulator family member A -0.00392332
TANK TRAF family member-associated NFKB activator -0.00391732
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.00389971
ANKRD36 ankyrin repeat domain 36 -0.00387714
XDH xanthine dehydrogenase -0.00386781
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.00386296
HELZ helicase with zinc finger -0.00385539
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.00383984
NT5C2 5'-nucleotidase, cytosolic II -0.00383844
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.00381279
RNF24 ring finger protein 24 -0.00380121
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.00375466
ICAM1 intercellular adhesion molecule 1 -0.00373122
ULK2 unc-51 like autophagy activating kinase 2 -0.00371735
CEP192 centrosomal protein 192kDa -0.00370556
VGLL4 vestigial-like family member 4 -0.00369854
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 -0.00369602