| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MEST | mesoderm specific transcript | 0.203806 |
| VIM | vimentin | 0.18248 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.17615 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.123886 |
| LDHA | lactate dehydrogenase A | 0.107213 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.104137 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0842406 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0687326 |
| RPS6 | ribosomal protein S6 | 0.0684957 |
| FN1 | fibronectin 1 | 0.0674821 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0630711 |
| ENO1 | enolase 1, (alpha) | 0.0629446 |
| PKM | pyruvate kinase, muscle | 0.0572444 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0506223 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0491526 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0479856 |
| NDRG1 | N-myc downstream regulated 1 | 0.0473852 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0463262 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0459511 |
| RPS2 | ribosomal protein S2 | 0.0452518 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.043047 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0421881 |
| RACK1 | receptor for activated C kinase 1 | 0.0418943 |
| RPS12 | ribosomal protein S12 | 0.0414443 |
| TMSB4X | thymosin beta 4, X-linked | 0.0408259 |
| FTL | ferritin, light polypeptide | 0.0399963 |
| SET | SET nuclear proto-oncogene | 0.0395507 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.03915 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0378219 |
| MKI67 | marker of proliferation Ki-67 | 0.0375721 |
| TPI1 | triosephosphate isomerase 1 | 0.0372247 |
| BRD2 | bromodomain containing 2 | 0.0363477 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.035586 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0355163 |
| SMC1A | structural maintenance of chromosomes 1A | 0.035401 |
| PGK1 | phosphoglycerate kinase 1 | 0.0347633 |
| ADM | adrenomedullin | 0.0345211 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0343996 |
| H3-3B | H3.3 histone B | 0.0335733 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0330437 |
| VEGFA | vascular endothelial growth factor A | 0.0328315 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0322382 |
| UBC | ubiquitin C | 0.0318329 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0318069 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.031239 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0303411 |
| DSTN | destrin (actin depolymerizing factor) | 0.0302661 |
| MGP | matrix Gla protein | 0.030192 |
| HMGA1 | high mobility group AT-hook 1 | 0.0300031 |
| BPTF | bromodomain PHD finger transcription factor | 0.0297441 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0296389 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0294795 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0294424 |
| TXNRD1 | thioredoxin reductase 1 | 0.0292284 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0287737 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | 0.0286517 |
| PTMA | prothymosin, alpha | 0.0284172 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0283862 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0283558 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.028236 |
| RPL11 | ribosomal protein L11 | 0.0276749 |
| CDK6 | cyclin-dependent kinase 6 | 0.0275231 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0275066 |
| RPL18 | ribosomal protein L18 | 0.027466 |
| RPL32 | ribosomal protein L32 | 0.0269875 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0263647 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.026049 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0258926 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0258513 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0256591 |
| SQSTM1 | sequestosome 1 | 0.025324 |
| CALR | calreticulin | 0.0252406 |
| POTEF | POTE ankyrin domain family, member F | 0.0251171 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0249893 |
| RHOA | ras homolog family member A | 0.0249506 |
| RPL7 | ribosomal protein L7 | 0.0248223 |
| S100A10 | S100 calcium binding protein A10 | 0.0242868 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.023848 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0236817 |
| RPS5 | ribosomal protein S5 | 0.0233073 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0229731 |
| TFRC | transferrin receptor | 0.0229434 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0229159 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0228807 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0228487 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0227368 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0226062 |
| MSN | moesin | 0.0222047 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0221484 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0221116 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0220986 |
| FBL | fibrillarin | 0.0219561 |
| RPL7A | ribosomal protein L7a | 0.021949 |
| ARRDC3 | arrestin domain containing 3 | 0.0219477 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0218259 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0217039 |
| H1-0 | H1.0 linker histone | 0.0216055 |
| RPL15 | ribosomal protein L15 | 0.0214969 |
| RPLP2 | ribosomal protein, large, P2 | 0.0214674 |
| EGR1 | early growth response 1 | 0.0213491 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.189701 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.120558 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.0932224 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0821167 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0801559 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0750124 |
| CADM2 | cell adhesion molecule 2 | -0.0749504 |
| MEOX2 | mesenchyme homeobox 2 | -0.0726143 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0626153 |
| JMJD1C | jumonji domain containing 1C | -0.061006 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0565465 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.056035 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0532984 |
| NBEA | neurobeachin | -0.0522418 |
| PDGFC | platelet derived growth factor C | -0.051598 |
| FNIP1 | folliculin interacting protein 1 | -0.051559 |
| ERBIN | erbb2 interacting protein | -0.0513957 |
| FBXO11 | F-box protein 11 | -0.0462227 |
| ZNF292 | zinc finger protein 292 | -0.0456967 |
| HMGA2 | high mobility group AT-hook 2 | -0.0452683 |
| NFIA | nuclear factor I/A | -0.0427867 |
| MED13L | mediator complex subunit 13-like | -0.0405028 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0404719 |
| SBF2 | SET binding factor 2 | -0.0395346 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0392392 |
| CTBP2 | C-terminal binding protein 2 | -0.038759 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0383285 |
| RPS24 | ribosomal protein S24 | -0.0373617 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0372967 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0356638 |
| SMYD3 | SET and MYND domain containing 3 | -0.0354767 |
| NFIB | nuclear factor I/B | -0.0350072 |
| TULP4 | tubby like protein 4 | -0.0347899 |
| PHF3 | PHD finger protein 3 | -0.0347582 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0345216 |
| RNF130 | ring finger protein 130 | -0.0342191 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.0337448 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0337051 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.033267 |
| AOPEP | aminopeptidase O (putative) | -0.0332022 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0331553 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0329986 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0328444 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0327336 |
| TCF12 | transcription factor 12 | -0.0324376 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0323259 |
| UTRN | utrophin | -0.0317672 |
| KAZN | kazrin, periplakin interacting protein | -0.0314989 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0314861 |
| CERT1 | ceramide transporter 1 | -0.0313348 |
| TUT4 | terminal uridylyl transferase 4 | -0.0311825 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0311572 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0307756 |
| VCL | vinculin | -0.0304944 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0301992 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.0301802 |
| MICU1 | mitochondrial calcium uptake 1 | -0.0299676 |
| GOLGA4 | golgin A4 | -0.029947 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.0297843 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0294067 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0293274 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0290716 |
| ZFHX3 | zinc finger homeobox 3 | -0.0289382 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0288327 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0288057 |
| MEF2A | myocyte enhancer factor 2A | -0.0283601 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0283071 |
| MDN1 | MDN1, midasin homolog (yeast) | -0.0282587 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0281497 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0279294 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0275986 |
| RHEB | Ras homolog enriched in brain | -0.02749 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0273677 |
| POU2F1 | POU class 2 homeobox 1 | -0.02696 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0266503 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.0265169 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0261191 |
| JAZF1 | JAZF zinc finger 1 | -0.0257146 |
| CREM | cAMP responsive element modulator | -0.025568 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0255092 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0254581 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0252419 |
| MATR3 | matrin 3 | -0.0251411 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | -0.0249506 |
| SIK3 | SIK family kinase 3 | -0.0248642 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0246752 |
| TRIM9 | tripartite motif containing 9 | -0.0246263 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0244585 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0240488 |
| MYOF | myoferlin | -0.0238491 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.023748 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0236929 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | -0.0235969 |
| BCOR | BCL6 corepressor | -0.0235923 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0235403 |
| HELZ | helicase with zinc finger | -0.0235351 |
| USP15 | ubiquitin specific peptidase 15 | -0.0234438 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0233285 |
| FAM13B | family with sequence similarity 13, member B | -0.0233065 |
| AK1 | adenylate kinase 1 | -0.0232363 |
