| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.191398 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.12444 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0720929 |
| VIM | vimentin | 0.0664399 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0557851 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0549618 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0549451 |
| NDRG1 | N-myc downstream regulated 1 | 0.0535326 |
| UBC | ubiquitin C | 0.0486654 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0450646 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.044794 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0426698 |
| SMAD3 | SMAD family member 3 | 0.0409107 |
| EFNA5 | ephrin-A5 | 0.0402381 |
| JMJD1C | jumonji domain containing 1C | 0.0394358 |
| LDHA | lactate dehydrogenase A | 0.038202 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0377975 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0361925 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0357715 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0354747 |
| PARD3 | par-3 family cell polarity regulator | 0.0342105 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0331701 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0322247 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0320294 |
| MED13L | mediator complex subunit 13-like | 0.0319982 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0309783 |
| TRRAP | transformation/transcription domain-associated protein | 0.0306134 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0302609 |
| PTK2 | protein tyrosine kinase 2 | 0.0296821 |
| HSPA8 | heat shock 70kDa protein 8 | 0.028842 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0287803 |
| MSN | moesin | 0.0284795 |
| RUNX1 | runt-related transcription factor 1 | 0.0280417 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0275718 |
| RPS12 | ribosomal protein S12 | 0.0274295 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0272192 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0271977 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0271081 |
| TPM3 | tropomyosin 3 | 0.0263637 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0263636 |
| RPS3 | ribosomal protein S3 | 0.0262829 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0261104 |
| PKM | pyruvate kinase, muscle | 0.0259739 |
| MCL1 | myeloid cell leukemia 1 | 0.0258781 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0257233 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0254447 |
| RPL7 | ribosomal protein L7 | 0.0254292 |
| PCBP2 | poly(rC) binding protein 2 | 0.0253274 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0252492 |
| TXNIP | thioredoxin interacting protein | 0.0250466 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.024898 |
| DIAPH1 | diaphanous-related formin 1 | 0.0247244 |
| B2M | beta-2-microglobulin | 0.0246295 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0245284 |
| MUC17 | mucin 17, cell surface associated | 0.0245096 |
| TGM2 | transglutaminase 2 | 0.0244847 |
| ERBIN | erbb2 interacting protein | 0.0241953 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0241487 |
| RCOR1 | REST corepressor 1 | 0.0238607 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0237918 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0235334 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0233213 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.023087 |
| SIK3 | SIK family kinase 3 | 0.0229552 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0229028 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0226346 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0225433 |
| RPL7A | ribosomal protein L7a | 0.0224145 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0222714 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0220637 |
| RACK1 | receptor for activated C kinase 1 | 0.0217717 |
| RIOK3 | RIO kinase 3 | 0.0217106 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0216548 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0216219 |
| FMNL2 | formin-like 2 | 0.0216115 |
| RPS8 | ribosomal protein S8 | 0.0210469 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0210424 |
| GDA | guanine deaminase | 0.0209901 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0206569 |
| SON | SON DNA binding protein | 0.020377 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0202559 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0199631 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0198974 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.0198148 |
| SETD5 | SET domain containing 5 | 0.0197523 |
| PLEC | plectin | 0.0197043 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0196794 |
| POTEF | POTE ankyrin domain family, member F | 0.0194262 |
| SP3 | Sp3 transcription factor | 0.0192917 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0190442 |
| CTBP2 | C-terminal binding protein 2 | 0.0189091 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.018893 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0188507 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0188451 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.01884 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0187428 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0186543 |
| YAP1 | Yes-associated protein 1 | 0.0185433 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0184657 |
| AHR | aryl hydrocarbon receptor | 0.0183805 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMB3 | laminin, beta 3 | -0.266664 |
| LMO7 | LIM domain 7 | -0.130149 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.108425 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.10136 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0893945 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0726712 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.072352 |
| TMSB10 | thymosin beta 10 | -0.0655194 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.0615842 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0572201 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0565105 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0535138 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0481416 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0478181 |
| KLK10 | kallikrein-related peptidase 10 | -0.0477656 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0477286 |
| LAMA4 | laminin, alpha 4 | -0.0459754 |
| PTMA | prothymosin, alpha | -0.0448526 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0444308 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.0443018 |
| RPL35A | ribosomal protein L35a | -0.0424809 |
| TPM4 | tropomyosin 4 | -0.040685 |
| S100A4 | S100 calcium binding protein A4 | -0.039118 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0389887 |
| AHNAK | AHNAK nucleoprotein | -0.0384726 |
| RPL34 | ribosomal protein L34 | -0.0383803 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0352907 |
| GNAS | GNAS complex locus | -0.0344738 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0337688 |
| RRBP1 | ribosome binding protein 1 | -0.0322583 |
| TMEM263 | transmembrane protein 263 | -0.0316786 |
| KLF6 | Kruppel-like factor 6 | -0.0315477 |
| NPSR1 | neuropeptide S receptor 1 | -0.0312233 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0303627 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0300955 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0300464 |
| LAMC2 | laminin, gamma 2 | -0.0298353 |
| SDC4 | syndecan 4 | -0.029779 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0297431 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0296464 |
| TXNRD1 | thioredoxin reductase 1 | -0.0293239 |
| FERMT1 | fermitin family member 1 | -0.0282315 |
| RPS21 | ribosomal protein S21 | -0.0282235 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0279391 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0278973 |
| DSG2 | desmoglein 2 | -0.0277018 |
| RPS24 | ribosomal protein S24 | -0.0271805 |
| DENND2C | DENN/MADD domain containing 2C | -0.026857 |
| HDLBP | high density lipoprotein binding protein | -0.0267238 |
| MIDN | midnolin | -0.0264855 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0261085 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0256122 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0254304 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0245699 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0245283 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.023106 |
| THBD | thrombomodulin | -0.0221982 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0218697 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0212814 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0211825 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.0207661 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0206323 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0204393 |
| RIGI | RNA sensor RIG-I | -0.0203341 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0200869 |
| TGFA | transforming growth factor, alpha | -0.0200156 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0200046 |
| DIAPH2 | diaphanous-related formin 2 | -0.0195811 |
| EGR1 | early growth response 1 | -0.0195796 |
| SLC9A3R2 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 | -0.0192773 |
| ARF4 | ADP-ribosylation factor 4 | -0.0192171 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0186326 |
| EZR | ezrin | -0.0185456 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0181561 |
| STAG2 | stromal antigen 2 | -0.018143 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0178988 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0176819 |
| DDX50 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | -0.01764 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0175073 |
| AK1 | adenylate kinase 1 | -0.0173998 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0172262 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.0168498 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0168312 |
| CD2AP | CD2-associated protein | -0.0168042 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0167488 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0166599 |
| PLAT | plasminogen activator, tissue | -0.016633 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0165095 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0164611 |
| PRSS3 | protease, serine, 3 | -0.016357 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0163506 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.016261 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0162245 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0162234 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.016157 |
| SAV1 | salvador family WW domain containing protein 1 | -0.0159975 |
| PERP | PERP, TP53 apoptosis effector | -0.0159758 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -0.0159387 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0159173 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0155888 |
