LY-2584702 (tosylate salt)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY-2584702 (tosylate salt) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY-2584702 (tosylate salt)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.216041
PABPC1 poly(A) binding protein, cytoplasmic 1 0.121667
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.121443
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.110861
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.109301
CLTC clathrin, heavy chain (Hc) 0.100989
LOC102724023 ES1 protein homolog, mitochondrial 0.0997013
ITCH itchy E3 ubiquitin protein ligase 0.0887138
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.086869
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0841124
ALCAM activated leukocyte cell adhesion molecule 0.0814119
DUSP16 dual specificity phosphatase 16 0.0755024
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0727075
EXT1 exostosin glycosyltransferase 1 0.0724278
FTH1 ferritin, heavy polypeptide 1 0.0703123
CLEC2D C-type lectin domain family 2, member D 0.0635879
PRRC2C proline-rich coiled-coil 2C 0.063502
CATSPERB catsper channel auxiliary subunit beta 0.0629557
VMP1 vacuole membrane protein 1 0.0624522
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0612436
CDK12 cyclin-dependent kinase 12 0.0611723
FBXL20 F-box and leucine-rich repeat protein 20 0.0575231
LDHA lactate dehydrogenase A 0.0554114
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0551981
MYO10 myosin X 0.0549949
FNDC3A fibronectin type III domain containing 3A 0.0548384
KTN1 kinectin 1 (kinesin receptor) 0.0545093
CCNI cyclin I 0.0531453
KMT2C lysine (K)-specific methyltransferase 2C 0.0525106
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0514786
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0512429
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0499806
SERINC3 serine incorporator 3 0.0487658
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.0473154
NRIP1 nuclear receptor interacting protein 1 0.0465623
ANKRD12 ankyrin repeat domain 12 0.0465009
BPTF bromodomain PHD finger transcription factor 0.0454969
RAB22A RAB22A, member RAS oncogene family 0.0453536
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0447671
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0447004
MBD4 methyl-CpG binding domain protein 4 0.0445126
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0426737
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0423053
STRN3 striatin, calmodulin binding protein 3 0.0421863
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0421714
UBC ubiquitin C 0.0417278
NF1 neurofibromin 1 0.0413324
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0412175
NCOA6 nuclear receptor coactivator 6 0.0412066
MED13L mediator complex subunit 13-like 0.0407883
SETD5 SET domain containing 5 0.0403745
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0392186
CXCL8 chemokine (C-X-C motif) ligand 8 0.0389779
CCNL1 cyclin L1 0.0388277
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0382251
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0382103
KIAA1217 KIAA1217 0.0381364
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0380845
SRRM2 serine/arginine repetitive matrix 2 0.037964
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0376866
RAB7A RAB7A, member RAS oncogene family 0.037466
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0371485
VAV3 vav 3 guanine nucleotide exchange factor 0.0370339
PAWR PRKC, apoptosis, WT1, regulator 0.0369351
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.036917
ASPH aspartate beta-hydroxylase 0.0364966
PTK2 protein tyrosine kinase 2 0.0359702
DSTN destrin (actin depolymerizing factor) 0.0356728
SEPTIN9 septin 9 0.0356491
CREB5 cAMP responsive element binding protein 5 0.0356464
CSDE1 cold shock domain containing E1, RNA-binding 0.0352561
KMT2E lysine (K)-specific methyltransferase 2E 0.0350527
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0350366
IGFBP5 insulin-like growth factor binding protein 5 0.0349224
RICTOR RPTOR independent companion of MTOR, complex 2 0.0348538
CEMIP cell migration inducing protein, hyaluronan binding 0.0347786
DYNLRB1 dynein, light chain, roadblock-type 1 0.0347025
SET SET nuclear proto-oncogene 0.0342829
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0342657
ZNF292 zinc finger protein 292 0.0340538
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0339983
KDM2A lysine (K)-specific demethylase 2A 0.0339228
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.0339114
B2M beta-2-microglobulin 0.0338198
SERF2 small EDRK-rich factor 2 0.0336737
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0333687
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0333604
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0332872
ENAH enabled homolog (Drosophila) 0.033114
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0328642
TRIP12 thyroid hormone receptor interactor 12 0.0325501
CSNK1A1 casein kinase 1, alpha 1 0.0324776
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0322701
SLC38A1 solute carrier family 38, member 1 0.0321998
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0321948
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0321358
JMJD1C jumonji domain containing 1C 0.0319771
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.031733
RIMS2 regulating synaptic membrane exocytosis 2 0.0316941
ICAM1 intercellular adhesion molecule 1 0.0314243

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0664537
RPL37A ribosomal protein L37a -0.0648186
RPS29 ribosomal protein S29 -0.0581506
TPT1 tumor protein, translationally-controlled 1 -0.0469874
RPL23 ribosomal protein L23 -0.043707
RPL31 ribosomal protein L31 -0.0378155
RPL36 ribosomal protein L36 -0.0352757
RPL35A ribosomal protein L35a -0.0346382
RPL9 ribosomal protein L9 -0.0342625
RPS17 ribosomal protein S17 -0.0331641
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0325209
RPLP2 ribosomal protein, large, P2 -0.0313989
RPS12 ribosomal protein S12 -0.0305748
NDRG1 N-myc downstream regulated 1 -0.0302111
RPL28 ribosomal protein L28 -0.0301524
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0299053
NABP1 nucleic acid binding protein 1 -0.027119
RPS27A ribosomal protein S27a -0.0264951
RPS13 ribosomal protein S13 -0.0262247
RPS23 ribosomal protein S23 -0.0261534
RPS6 ribosomal protein S6 -0.0261142
RPS21 ribosomal protein S21 -0.0253183
RPS11 ribosomal protein S11 -0.0243034
RPL12 ribosomal protein L12 -0.0237123
WSB1 WD repeat and SOCS box containing 1 -0.0220795
RPS15 ribosomal protein S15 -0.0214085
FASN fatty acid synthase -0.0208458
RPL35 ribosomal protein L35 -0.0208309
RPS25 ribosomal protein S25 -0.0206764
MMP24OS MMP24 opposite strand -0.0200556
RPL13A ribosomal protein L13a -0.0198872
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0188349
RPS10 ribosomal protein S10 -0.0186124
TMSB10 thymosin beta 10 -0.0178276
RPL26 ribosomal protein L26 -0.0176631
RPL38 ribosomal protein L38 -0.0175411
RPL7A ribosomal protein L7a -0.0173809
PRR11 proline rich 11 -0.0173771
S100P S100 calcium binding protein P -0.0172091
RPS14 ribosomal protein S14 -0.0169476
ACTG1 actin gamma 1 -0.0166659
RPS19 ribosomal protein S19 -0.0165452
ATAD2 ATPase family, AAA domain containing 2 -0.016274
PRELID2 PRELI domain containing 2 -0.0158867
RPS8 ribosomal protein S8 -0.0156118
RPL36A ribosomal protein L36a -0.01509
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0147047
TUBB4B tubulin, beta 4B class IVb -0.014604
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0143658
KRT86 keratin 86, type II -0.0142861
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0140558
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0139741
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.013704
VCL vinculin -0.0136267
ATF4 activating transcription factor 4 -0.0135701
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0135493
PLSCR2 phospholipid scramblase 2 -0.013504
ENO2 enolase 2 (gamma, neuronal) -0.0134447
RPS24 ribosomal protein S24 -0.0134061
GRB10 growth factor receptor-bound protein 10 -0.0132495
RPS27 ribosomal protein S27 -0.0130855
S100A11 S100 calcium binding protein A11 -0.0129135
RPL8 ribosomal protein L8 -0.0128157
HLA-B major histocompatibility complex, class I, B -0.0128052
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0127108
LASP1 LIM and SH3 protein 1 -0.0126991
GDF5 growth differentiation factor 5 -0.0125532
ANLN anillin, actin binding protein -0.0125148
ISG15 ISG15 ubiquitin-like modifier -0.0125122
NPC2 Niemann-Pick disease, type C2 -0.0123507
NDUFA4 NDUFA4, mitochondrial complex associated -0.012349
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0120642
PABPC1L poly(A) binding protein, cytoplasmic 1-like -0.012037
GMDS GDP-mannose 4,6-dehydratase -0.0120142
MAP4 microtubule-associated protein 4 -0.0119035
SLC38A2 solute carrier family 38, member 2 -0.0118991
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0118325
KDM4B lysine (K)-specific demethylase 4B -0.011766
SRSF9 serine/arginine-rich splicing factor 9 -0.0117045
COX5A cytochrome c oxidase subunit Va -0.0114732
IER5 immediate early response 5 -0.0112519
DENND1A DENN/MADD domain containing 1A -0.011221
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0111567
RAD51B RAD51 paralog B -0.0111017
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0110736
MROH1 maestro heat-like repeat family member 1 -0.0110618
MYO19 myosin XIX -0.0109777
ECT2 epithelial cell transforming 2 -0.0108448
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0107785
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0107285
FLNB filamin B, beta -0.0106273
COX17 COX17 cytochrome c oxidase copper chaperone -0.0106099
EPPK1 epiplakin 1 -0.0105982
RPL5 ribosomal protein L5 -0.0105918
PILRA paired immunoglobin-like type 2 receptor alpha -0.0104724
CLMN calmin (calponin-like, transmembrane) -0.0104679
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0103296
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.010293
AHNAK AHNAK nucleoprotein -0.0102124
FOXK2 forkhead box K2 -0.0101278