LY-2584702 (tosylate salt)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY-2584702 (tosylate salt) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY-2584702 (tosylate salt)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.160357
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.122237
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.102141
SLIT2 slit homolog 2 (Drosophila) 0.0954945
PABPC1 poly(A) binding protein, cytoplasmic 1 0.087615
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0851281
ADGRG6 adhesion G protein-coupled receptor G6 0.0815757
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0804941
USP9X ubiquitin specific peptidase 9, X-linked 0.0673311
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0670037
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0659542
KTN1 kinectin 1 (kinesin receptor) 0.0634074
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0620282
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0613699
LDHA lactate dehydrogenase A 0.0572198
JMJD1C jumonji domain containing 1C 0.0557945
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.053171
EEF2 eukaryotic translation elongation factor 2 0.0526849
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0512928
GJA1 gap junction protein, alpha 1, 43kDa 0.0501733
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0501509
VMP1 vacuole membrane protein 1 0.0491298
ERBB4 erb-b2 receptor tyrosine kinase 4 0.048542
COL5A2 collagen, type V, alpha 2 0.0480575
TOX thymocyte selection-associated high mobility group box 0.0467836
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0461519
SRRM2 serine/arginine repetitive matrix 2 0.0457111
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0456906
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.045669
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0450248
RPL11 ribosomal protein L11 0.0448213
ZNF608 zinc finger protein 608 0.0440039
SOX5 SRY (sex determining region Y)-box 5 0.0407468
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0401975
NFIA nuclear factor I/A 0.0396633
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.039578
ENO1 enolase 1, (alpha) 0.0391352
SOX4 SRY (sex determining region Y)-box 4 0.0384542
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0383022
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0373533
NPAS3 neuronal PAS domain protein 3 0.037304
CADM2 cell adhesion molecule 2 0.0371975
CDH18 cadherin 18, type 2 0.0370869
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0366824
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0365646
TENM3 teneurin transmembrane protein 3 0.0363353
VCL vinculin 0.0363068
GNAS GNAS complex locus 0.0362733
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0362727
TTC3 tetratricopeptide repeat domain 3 0.0362575
FMNL2 formin-like 2 0.0361042
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0360802
NCOR1 nuclear receptor corepressor 1 0.0358891
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.035698
RAP1B RAP1B, member of RAS oncogene family 0.0353456
DST dystonin 0.0352046
CELF2 CUGBP, Elav-like family member 2 0.0351995
PTMA prothymosin, alpha 0.034979
PGK1 phosphoglycerate kinase 1 0.0348963
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0346676
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0345374
SIK3 SIK family kinase 3 0.0345211
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0337721
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0333076
SERBP1 SERPINE1 mRNA binding protein 1 0.0329253
DSCAM Down syndrome cell adhesion molecule 0.0327596
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0325216
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0324444
PCM1 pericentriolar material 1 0.0324349
UBC ubiquitin C 0.0318636
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0316329
KMT2C lysine (K)-specific methyltransferase 2C 0.0314276
SOX2 SRY (sex determining region Y)-box 2 0.0313648
MED13 mediator complex subunit 13 0.0313503
DEK DEK proto-oncogene 0.0313393
BPTF bromodomain PHD finger transcription factor 0.0313268
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0308509
KPNB1 karyopherin (importin) beta 1 0.0300777
RPLP0 ribosomal protein, large, P0 0.0297064
NGLY1 N-glycanase 1 0.0296753
ZFP36L1 ZFP36 ring finger protein-like 1 0.0296717
KIF5B kinesin family member 5B 0.0296581
SHROOM3 shroom family member 3 0.0293593
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0293134
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0290789
RERE arginine-glutamic acid dipeptide (RE) repeats 0.028889
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0288887
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0287936
RLF rearranged L-myc fusion 0.0287684
MATR3 matrin 3 0.0287161
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0283007
NBEAL1 neurobeachin-like 1 0.0279863
IPO7 importin 7 0.0278143
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0278134
RPLP1 ribosomal protein, large, P1 0.0278005
BCLAF1 BCL2-associated transcription factor 1 0.0277018
RSRC2 arginine/serine-rich coiled-coil 2 0.0270706
NALF1 NALCN channel auxiliary factor 1 0.0269307
SMYD3 SET and MYND domain containing 3 0.0269072
NUP58 nucleoporin 58 0.0268377

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.0604184
VIM vimentin -0.0458867
TPT1 tumor protein, translationally-controlled 1 -0.0431202
RPL37A ribosomal protein L37a -0.0403243
IGF2 insulin-like growth factor 2 -0.0387816
RPS23 ribosomal protein S23 -0.0349095
RPS29 ribosomal protein S29 -0.0302901
FTL ferritin, light polypeptide -0.0295133
RPL31 ribosomal protein L31 -0.0282809
TMSB10 thymosin beta 10 -0.0267049
RPS13 ribosomal protein S13 -0.0266954
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.026025
NDRG1 N-myc downstream regulated 1 -0.0238546
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0236135
RPLP2 ribosomal protein, large, P2 -0.0231354
HLA-B major histocompatibility complex, class I, B -0.0224755
S100A6 S100 calcium binding protein A6 -0.0199048
ENO2 enolase 2 (gamma, neuronal) -0.0189653
RPL9 ribosomal protein L9 -0.0179969
FN1 fibronectin 1 -0.0176742
FASN fatty acid synthase -0.0168957
RPL38 ribosomal protein L38 -0.0157753
HLA-A major histocompatibility complex, class I, A -0.0155458
RPL36 ribosomal protein L36 -0.0155098
SP100 SP100 nuclear antigen -0.0154066
RPL35A ribosomal protein L35a -0.0150392
TIMP2 TIMP metallopeptidase inhibitor 2 -0.014585
TM4SF1 transmembrane 4 L six family member 1 -0.0145006
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0143769
RPS27 ribosomal protein S27 -0.0137135
LMO7 LIM domain 7 -0.0136559
TRIO trio Rho guanine nucleotide exchange factor -0.0134611
CD44 CD44 molecule (Indian blood group) -0.013449
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0134432
SQSTM1 sequestosome 1 -0.013025
RPL36A ribosomal protein L36a -0.0130164
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0127839
IER3 immediate early response 3 -0.0126176
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0123872
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0122091
BASP1 brain abundant, membrane attached signal protein 1 -0.0119595
KDM4B lysine (K)-specific demethylase 4B -0.0118677
AREG amphiregulin -0.0117431
RUNX1 runt-related transcription factor 1 -0.0117182
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0116912
CENPE centromere protein E, 312kDa -0.0116643
RPS19 ribosomal protein S19 -0.0116314
VEGFA vascular endothelial growth factor A -0.0116136
DNHD1 dynein heavy chain domain 1 -0.0115987
NRF1 nuclear respiratory factor 1 -0.0115777
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.011353
ADM adrenomedullin -0.0113188
WDR27 WD repeat domain 27 -0.0112958
KIF4A kinesin family member 4A -0.0111917
TOM1L2 target of myb1-like 2 (chicken) -0.0111861
IFITM3 interferon induced transmembrane protein 3 -0.0111458
LMNA lamin A/C -0.0111013
FGFR2 fibroblast growth factor receptor 2 -0.0110555
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0110153
RPTOR regulatory associated protein of MTOR, complex 1 -0.0110047
E2F3 E2F transcription factor 3 -0.010778
STC1 stanniocalcin 1 -0.010756
MTCL1 microtubule crosslinking factor 1 -0.0107047
HSPA1A heat shock 70kDa protein 1A -0.0104932
HSPB1 heat shock 27kDa protein 1 -0.0104888
IFI27 interferon, alpha-inducible protein 27 -0.0103278
LAMA5 laminin, alpha 5 -0.0102886
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0102822
S100A10 S100 calcium binding protein A10 -0.0100214
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0099382
DTNA dystrobrevin, alpha -0.00979671
MRPL51 mitochondrial ribosomal protein L51 -0.00979057
ALCAM activated leukocyte cell adhesion molecule -0.00963685
MAML2 mastermind-like 2 (Drosophila) -0.00952511
CDCP1 CUB domain containing protein 1 -0.00936702
TFPI2 tissue factor pathway inhibitor 2 -0.00934296
LARP1B La ribonucleoprotein domain family, member 1B -0.00932774
TGFBI transforming growth factor, beta-induced, 68kDa -0.00928811
RPL19 ribosomal protein L19 -0.00911303
APOA2 apolipoprotein A-II -0.00909112
RPS27A ribosomal protein S27a -0.00901769
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.00899717
CTSD cathepsin D -0.0089965
MYOF myoferlin -0.00894566
TIMP3 TIMP metallopeptidase inhibitor 3 -0.00889314
MRPS25 mitochondrial ribosomal protein S25 -0.00880427
SLC38A2 solute carrier family 38, member 2 -0.00878323
SGMS1 sphingomyelin synthase 1 -0.00877095
IFI44 interferon-induced protein 44 -0.00872065
MON2 MON2 homolog (S. cerevisiae) -0.00870596
PRKG1 protein kinase, cGMP-dependent, type I -0.00868097
PLAUR plasminogen activator, urokinase receptor -0.00862633
RPS15 ribosomal protein S15 -0.00848232
S100A11 S100 calcium binding protein A11 -0.00847078
ITPRID2 ITPR interacting domain containing 2 -0.00844624
HDAC4 histone deacetylase 4 -0.00843615
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.00841369
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00839783
CDK1 cyclin-dependent kinase 1 -0.00837951
CD63 CD63 molecule -0.00831215