| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.109142 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.103491 |
| FMN1 | formin 1 | 0.0717607 |
| GPC6 | glypican 6 | 0.0675734 |
| MT2A | metallothionein 2A | 0.0596539 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0524955 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0452777 |
| FMNL2 | formin-like 2 | 0.0452283 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0435011 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0433183 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.043093 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0416838 |
| MCL1 | myeloid cell leukemia 1 | 0.041168 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0402379 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0401415 |
| VCL | vinculin | 0.0397819 |
| FN1 | fibronectin 1 | 0.0387647 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0371237 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0353915 |
| DSCAM | Down syndrome cell adhesion molecule | 0.034679 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0340212 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0338831 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0335964 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0322932 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0310731 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0309972 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0301744 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0295118 |
| MRTFA | myocardin related transcription factor A | 0.0290767 |
| COPA | coatomer protein complex, subunit alpha | 0.0289416 |
| CDC73 | cell division cycle 73 | 0.0285058 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0283988 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0281791 |
| ACTN1 | actinin, alpha 1 | 0.0281746 |
| VMP1 | vacuole membrane protein 1 | 0.027286 |
| COG5 | component of oligomeric golgi complex 5 | 0.0260125 |
| EFR3B | EFR3 homolog B (S. cerevisiae) | 0.0259112 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0258935 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0256693 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0256648 |
| INTS6 | integrator complex subunit 6 | 0.0255679 |
| NAV2 | neuron navigator 2 | 0.0254719 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0254427 |
| AFDN | afadin, adherens junction formation factor | 0.0252501 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0249972 |
| ZNF292 | zinc finger protein 292 | 0.0248354 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0248194 |
| ZYX | zyxin | 0.0247817 |
| INPP5F | inositol polyphosphate-5-phosphatase F | 0.0247801 |
| SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 | 0.0246901 |
| PRELID2 | PRELI domain containing 2 | 0.0244217 |
| CCNL1 | cyclin L1 | 0.0242082 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0240132 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0239242 |
| RASA3 | RAS p21 protein activator 3 | 0.0238274 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0237995 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0236102 |
| ARRDC3 | arrestin domain containing 3 | 0.0233736 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0233248 |
| CLIC4 | chloride intracellular channel 4 | 0.0232226 |
| SRPK2 | SRSF protein kinase 2 | 0.0230861 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0227222 |
| SERINC1 | serine incorporator 1 | 0.0225285 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0224759 |
| TMEM178B | transmembrane protein 178B | 0.0223653 |
| PAX3 | paired box 3 | 0.0221328 |
| FBXO32 | F-box protein 32 | 0.0220176 |
| JUN | jun proto-oncogene | 0.0217869 |
| RBM33 | RNA binding motif protein 33 | 0.0216772 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0213639 |
| ADM | adrenomedullin | 0.0211744 |
| TLE4 | transducin-like enhancer of split 4 | 0.021136 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0207836 |
| ANXA2 | annexin A2 | 0.0207733 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0206614 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0200476 |
| TNNC1 | troponin C type 1 (slow) | 0.0199965 |
| RHEB | Ras homolog enriched in brain | 0.0198527 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0197195 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0196936 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0196762 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0196594 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.019633 |
| HBP1 | HMG-box transcription factor 1 | 0.0195938 |
| APP | amyloid beta (A4) precursor protein | 0.0195451 |
| PI15 | peptidase inhibitor 15 | 0.0192203 |
| EMP1 | epithelial membrane protein 1 | 0.0191139 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0190859 |
| FOXJ3 | forkhead box J3 | 0.0190154 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0188325 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0188191 |
| EFCAB13 | EF-hand calcium binding domain 13 | 0.018638 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0186241 |
| OGA | O-GlcNAcase | 0.0184872 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0183548 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0182751 |
| NEK7 | NIMA-related kinase 7 | 0.0182576 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0181039 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0179922 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0179487 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.160664 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.159107 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.158502 |
| VIM | vimentin | -0.156073 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.138724 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.132446 |
| DCT | dopachrome tautomerase | -0.129305 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.126426 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.103268 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.100685 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.092232 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0887758 |
| CENPF | centromere protein F, 350/400kDa | -0.0788056 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0700488 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0586827 |
| TRIM2 | tripartite motif containing 2 | -0.0578962 |
| INSIG1 | insulin induced gene 1 | -0.0569385 |
| CALD1 | caldesmon 1 | -0.056613 |
| TAGLN2 | transgelin 2 | -0.0565002 |
| TMSB10 | thymosin beta 10 | -0.0562256 |
| POTEF | POTE ankyrin domain family, member F | -0.0550986 |
| ENO1 | enolase 1, (alpha) | -0.0546953 |
| GDF15 | growth differentiation factor 15 | -0.0541235 |
| PKM | pyruvate kinase, muscle | -0.0536822 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.051357 |
| S100A6 | S100 calcium binding protein A6 | -0.0512879 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0489396 |
| TMEM123 | transmembrane protein 123 | -0.0480718 |
| PLIN2 | perilipin 2 | -0.0477044 |
| EHBP1 | EH domain binding protein 1 | -0.0466521 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0460191 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0457334 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0455428 |
| HLA-B | major histocompatibility complex, class I, B | -0.0444394 |
| ZNF704 | zinc finger protein 704 | -0.0421147 |
| CDK14 | cyclin-dependent kinase 14 | -0.0412855 |
| SCFD2 | sec1 family domain containing 2 | -0.0407658 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0404654 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0401947 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0383649 |
| GNAS | GNAS complex locus | -0.0381143 |
| MTDH | metadherin | -0.0370911 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0369067 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.036826 |
| NAV3 | neuron navigator 3 | -0.036749 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.036109 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.0357947 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0345518 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0343519 |
| RFX7 | regulatory factor X, 7 | -0.0342062 |
| CANX | calnexin | -0.0339298 |
| CTTNBP2 | cortactin binding protein 2 | -0.0335102 |
| MACROD2 | MACRO domain containing 2 | -0.0334168 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0332188 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0328861 |
| OXR1 | oxidation resistance 1 | -0.0327497 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0321727 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0320242 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0313738 |
| VGF | VGF nerve growth factor inducible | -0.0313336 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0310181 |
| NAV1 | neuron navigator 1 | -0.0302029 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0301341 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0294134 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0284994 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0284923 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0279252 |
| FTL | ferritin, light polypeptide | -0.0279087 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0277149 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.0274512 |
| S100A9 | S100 calcium binding protein A9 | -0.0273055 |
| PTMA | prothymosin, alpha | -0.0272868 |
| FRMD4A | FERM domain containing 4A | -0.0271198 |
| PGK1 | phosphoglycerate kinase 1 | -0.0268027 |
| LRAT | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | -0.0267812 |
| ASPH | aspartate beta-hydroxylase | -0.0260421 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0260177 |
| PFN1 | profilin 1 | -0.0259377 |
| TAC4 | tachykinin 4 (hemokinin) | -0.0256582 |
| CUX1 | cut-like homeobox 1 | -0.0255165 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0250583 |
| FAM162A | family with sequence similarity 162, member A | -0.0248808 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0247942 |
| CTSD | cathepsin D | -0.0247779 |
| PTMS | parathymosin | -0.0245603 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0245397 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0243405 |
| ACLY | ATP citrate lyase | -0.0240346 |
| RNF24 | ring finger protein 24 | -0.0240187 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0232183 |
| HMGB1 | high mobility group box 1 | -0.0231279 |
| ACTG1 | actin gamma 1 | -0.0231079 |
| CLMN | calmin (calponin-like, transmembrane) | -0.0228436 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0227935 |
| LDHA | lactate dehydrogenase A | -0.0227359 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0226631 |
| RPLP1 | ribosomal protein, large, P1 | -0.0223584 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0223328 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0222415 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0222075 |
