LY-2584702 (tosylate salt)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY-2584702 (tosylate salt) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY-2584702 (tosylate salt)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.193269
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.172095
IGF2 insulin-like growth factor 2 0.137354
FMN1 formin 1 0.0819863
ACTG1 actin gamma 1 0.0651598
AKAP12 A kinase (PRKA) anchor protein 12 0.0622157
RPL23 ribosomal protein L23 0.0598905
VIM vimentin 0.0557669
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.054946
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0521198
RPS6 ribosomal protein S6 0.0496594
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0491503
TLE4 transducin-like enhancer of split 4 0.048958
BPTF bromodomain PHD finger transcription factor 0.0481381
EIF1 eukaryotic translation initiation factor 1 0.0456953
MEIS2 Meis homeobox 2 0.0454362
EXT1 exostosin glycosyltransferase 1 0.0445857
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0438932
RPL19 ribosomal protein L19 0.0431622
PTMA prothymosin, alpha 0.0415088
B2M beta-2-microglobulin 0.0392417
SYT1 synaptotagmin I 0.0377367
RPL34 ribosomal protein L34 0.0359231
NAP1L1 nucleosome assembly protein 1-like 1 0.033873
VCL vinculin 0.0337074
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0331229
PTPRD protein tyrosine phosphatase, receptor type, D 0.0315394
SOS1 son of sevenless homolog 1 (Drosophila) 0.0311467
DST dystonin 0.0306403
RPLP1 ribosomal protein, large, P1 0.0304357
TPT1 tumor protein, translationally-controlled 1 0.0302864
RPLP0 ribosomal protein, large, P0 0.0296779
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0295309
SLITRK6 SLIT and NTRK-like family, member 6 0.029288
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0280694
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0275032
LSAMP limbic system-associated membrane protein 0.0272949
ZSWIM6 zinc finger, SWIM-type containing 6 0.0271035
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0268858
RPL7A ribosomal protein L7a 0.0266886
PRRC2C proline-rich coiled-coil 2C 0.0259251
RACK1 receptor for activated C kinase 1 0.0256083
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0255895
H3-3B H3.3 histone B 0.02542
FNBP1 formin binding protein 1 0.0251765
KLHL13 kelch-like family member 13 0.0245953
IFI16 interferon, gamma-inducible protein 16 0.0239876
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0237308
RPL32 ribosomal protein L32 0.0235365
RPS12 ribosomal protein S12 0.0234506
COL1A1 collagen, type I, alpha 1 0.0226204
RPL7 ribosomal protein L7 0.022565
RPS3 ribosomal protein S3 0.0225444
RPL26 ribosomal protein L26 0.0223317
TIMP3 TIMP metallopeptidase inhibitor 3 0.0221191
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0219257
CLTC clathrin, heavy chain (Hc) 0.0216833
RPS5 ribosomal protein S5 0.0214645
ENO1 enolase 1, (alpha) 0.0211649
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.021009
RPL35A ribosomal protein L35a 0.0208373
RNF213 ring finger protein 213 0.0208241
SLIT2 slit homolog 2 (Drosophila) 0.0207845
FTL ferritin, light polypeptide 0.0206867
TRIO trio Rho guanine nucleotide exchange factor 0.0206368
PLPP1 phospholipid phosphatase 1 0.0205228
EEF2 eukaryotic translation elongation factor 2 0.0204646
CALD1 caldesmon 1 0.0200171
IER3 immediate early response 3 0.0199134
MED13 mediator complex subunit 13 0.0198476
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0195405
RPS24 ribosomal protein S24 0.0195396
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0194665
RPL12 ribosomal protein L12 0.0192282
TPI1 triosephosphate isomerase 1 0.0188815
GLCCI1 glucocorticoid induced 1 0.0185266
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0184196
RPL31 ribosomal protein L31 0.0179978
KPNB1 karyopherin (importin) beta 1 0.0175737
ENAH enabled homolog (Drosophila) 0.0175183
DCAF7 DDB1 and CUL4 associated factor 7 0.0174839
FAM13A family with sequence similarity 13, member A 0.0174342
RPS27 ribosomal protein S27 0.0172939
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0172253
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0171972
ADAR adenosine deaminase, RNA-specific 0.0169052
CRH corticotropin releasing hormone 0.0168552
EGR1 early growth response 1 0.0167512
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.016525
PTPRK protein tyrosine phosphatase, receptor type, K 0.0164438
BCAS3 breast carcinoma amplified sequence 3 0.0164199
TBX2 T-box 2 0.0163096
SP100 SP100 nuclear antigen 0.0161981
NFE2L2 nuclear factor, erythroid 2-like 2 0.0161187
COL3A1 collagen, type III, alpha 1 0.0160954
THSD4 thrombospondin, type I, domain containing 4 0.0156653
MYO6 myosin VI 0.0155743
TPST1 tyrosylprotein sulfotransferase 1 0.0154728
RSL1D1 ribosomal L1 domain containing 1 0.0154572
RPL38 ribosomal protein L38 0.0153735

decreased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding -0.0197169
GPC5 glypican 5 -0.0123353
DTNA dystrobrevin, alpha -0.0109512
FRMD4A FERM domain containing 4A -0.0107054
MAML2 mastermind-like 2 (Drosophila) -0.0105602
EGFR epidermal growth factor receptor -0.0103479
UBA6 ubiquitin-like modifier activating enzyme 6 -0.010256
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.00972803
CDH13 cadherin 13 -0.00902951
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.00867106
DLG1 discs, large homolog 1 (Drosophila) -0.00834219
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.00820697
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.00818612
SRPK2 SRSF protein kinase 2 -0.00780893
TENT4A terminal nucleotidyltransferase 4A -0.00768946
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.00767682
CEP95 centrosomal protein 95kDa -0.00748803
PICALM phosphatidylinositol binding clathrin assembly protein -0.00742732
SAMD4A sterile alpha motif domain containing 4A -0.00739603
MRPS6 mitochondrial ribosomal protein S6 -0.00728458
AK1 adenylate kinase 1 -0.00720423
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.00711278
NEK7 NIMA-related kinase 7 -0.00706045
ELF2 E74-like factor 2 (ets domain transcription factor) -0.00705174
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.00697826
RFX7 regulatory factor X, 7 -0.00696895
LENG8 leukocyte receptor cluster (LRC) member 8 -0.00694697
ANKRD50 ankyrin repeat domain 50 -0.00687235
QKI QKI, KH domain containing, RNA binding -0.00682673
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.00666115
GPR75-ASB3 GPR75-ASB3 readthrough -0.00666048
AUH AU RNA binding protein/enoyl-CoA hydratase -0.00650458
MON2 MON2 homolog (S. cerevisiae) -0.00650144
DHFR dihydrofolate reductase -0.00646918
PCBP2 poly(rC) binding protein 2 -0.00638576
BLTP1 bridge-like lipid transfer protein family member 1 -0.00637047
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.0062983
SPAG9 sperm associated antigen 9 -0.00629628
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.00628503
SSBP2 single-stranded DNA binding protein 2 -0.00617442
PTPRM protein tyrosine phosphatase, receptor type, M -0.00615551
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.00613902
FASN fatty acid synthase -0.00610947
CHIC2 cysteine-rich hydrophobic domain 2 -0.00608339
TENM2 teneurin transmembrane protein 2 -0.00605035
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00600079
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.00597934
ZMAT3 zinc finger, matrin-type 3 -0.00597236
FOXK2 forkhead box K2 -0.00595859
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0059299
RBM33 RNA binding motif protein 33 -0.00585257
PTPRJ protein tyrosine phosphatase, receptor type, J -0.00583606
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.00581658
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.00581447
GARS1 glycyl-tRNA synthetase 1 -0.00579394
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.00578643
USP15 ubiquitin specific peptidase 15 -0.00575312
WRN Werner syndrome, RecQ helicase-like -0.00574864
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.00570937
RANBP9 RAN binding protein 9 -0.00569936
RREB1 ras responsive element binding protein 1 -0.00568559
PODXL podocalyxin-like -0.00561441
USP3 ubiquitin specific peptidase 3 -0.00561065
KDM6A lysine (K)-specific demethylase 6A -0.00560141
RNF24 ring finger protein 24 -0.00558526
PDCD6IP programmed cell death 6 interacting protein -0.00557751
MT2A metallothionein 2A -0.00556368
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00555302
VAV2 vav 2 guanine nucleotide exchange factor -0.00554815
PATJ PATJ crumbs cell polarity complex component -0.00551397
NAV3 neuron navigator 3 -0.00549837
FRYL FRY-like -0.0054976
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.00549051
MEMO1 mediator of cell motility 1 -0.0054545
NRG1 neuregulin 1 -0.00544299
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.00537246
LYST lysosomal trafficking regulator -0.0053723
SNX13 sorting nexin 13 -0.00535963
DIAPH3 diaphanous-related formin 3 -0.00528899
NT5C2 5'-nucleotidase, cytosolic II -0.0052263
DENND5A DENN/MADD domain containing 5A -0.00518144
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.00518122
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.00517035
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.00515915
TBC1D12 TBC1 domain family, member 12 -0.00512273
GRB10 growth factor receptor-bound protein 10 -0.00511579
PCNX1 pecanex 1 -0.00511295
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.00511191
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.00508545
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.00507206
NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.00506972
OXSR1 oxidative stress responsive 1 -0.00506143
COLEC11 collectin sub-family member 11 -0.00504833
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.00504434
KCTD3 potassium channel tetramerization domain containing 3 -0.00504372
FBXO34 F-box protein 34 -0.00503322
ANAPC1 anaphase promoting complex subunit 1 -0.00502433
PIAS2 protein inhibitor of activated STAT, 2 -0.0050189
IARS1 isoleucyl-tRNA synthetase 1 -0.00500711
URI1 URI1, prefoldin-like chaperone -0.00500656