| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | 0.104117 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.100534 |
| RNF213 | ring finger protein 213 | 0.0975309 |
| SP100 | SP100 nuclear antigen | 0.0866221 |
| LCN2 | lipocalin 2 | 0.0853554 |
| SMAD3 | SMAD family member 3 | 0.082728 |
| INTS6 | integrator complex subunit 6 | 0.0812759 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0755883 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.075392 |
| LMO7 | LIM domain 7 | 0.0708131 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0692123 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0683467 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0657355 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0653363 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0634417 |
| ASPH | aspartate beta-hydroxylase | 0.0626857 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0619491 |
| VCL | vinculin | 0.05923 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0583836 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0570639 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0553672 |
| PLSCR2 | phospholipid scramblase 2 | 0.053318 |
| RAD51B | RAD51 paralog B | 0.0506447 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0503783 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0501862 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0493243 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0491969 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0488494 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0469966 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.04599 |
| MX1 | MX dynamin-like GTPase 1 | 0.0456823 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0444878 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0429571 |
| ANXA2 | annexin A2 | 0.0429346 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0424561 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0424033 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0420246 |
| AREG | amphiregulin | 0.04126 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0411704 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0399619 |
| MX2 | MX dynamin-like GTPase 2 | 0.0392039 |
| LYZ | lysozyme | 0.0378951 |
| IFNGR1 | interferon gamma receptor 1 | 0.0377162 |
| XAF1 | XIAP associated factor 1 | 0.0374746 |
| RIGI | RNA sensor RIG-I | 0.0374367 |
| DST | dystonin | 0.0367763 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0367157 |
| MYO10 | myosin X | 0.036646 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0364042 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0362624 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0354923 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0353609 |
| PKM | pyruvate kinase, muscle | 0.0352077 |
| ERBIN | erbb2 interacting protein | 0.0342928 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0339601 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0338101 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0337742 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0336618 |
| YAP1 | Yes-associated protein 1 | 0.0336165 |
| MCU | mitochondrial calcium uniporter | 0.0330509 |
| B2M | beta-2-microglobulin | 0.0328772 |
| PRKCA | protein kinase C, alpha | 0.0325222 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0323904 |
| PERP | PERP, TP53 apoptosis effector | 0.0321938 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0321678 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0320497 |
| EPCAM | epithelial cell adhesion molecule | 0.0312167 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0305622 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0303745 |
| FAT1 | FAT atypical cadherin 1 | 0.0301889 |
| RPL7L1 | ribosomal protein L7-like 1 | 0.0293363 |
| MSI2 | musashi RNA-binding protein 2 | 0.0292386 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0290263 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.028767 |
| VMP1 | vacuole membrane protein 1 | 0.0286633 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0286585 |
| CUX1 | cut-like homeobox 1 | 0.0286449 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0285113 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0280827 |
| TRERF1 | transcriptional regulating factor 1 | 0.0280672 |
| DIAPH1 | diaphanous-related formin 1 | 0.0277504 |
| TJP1 | tight junction protein 1 | 0.0276068 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.0270919 |
| PARD3 | par-3 family cell polarity regulator | 0.0270456 |
| PTK2 | protein tyrosine kinase 2 | 0.0269543 |
| TMC5 | transmembrane channel-like 5 | 0.0267078 |
| ATXN1 | ataxin 1 | 0.0266749 |
| MYO5B | myosin VB | 0.0263326 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0262751 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0261061 |
| UBC | ubiquitin C | 0.0259983 |
| PMP22 | peripheral myelin protein 22 | 0.0258753 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0253683 |
| ZNF292 | zinc finger protein 292 | 0.0253446 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0252289 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0251305 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0250514 |
| ACTG1 | actin gamma 1 | 0.0250022 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0247053 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0246938 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.138402 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0788213 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0632542 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.056086 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0498533 |
| NDRG1 | N-myc downstream regulated 1 | -0.0474487 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0457924 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.04428 |
| IRF1 | interferon regulatory factor 1 | -0.0438816 |
| HLA-B | major histocompatibility complex, class I, B | -0.0426506 |
| TMSB10 | thymosin beta 10 | -0.0419419 |
| SQSTM1 | sequestosome 1 | -0.0417094 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.040959 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.040003 |
| HDLBP | high density lipoprotein binding protein | -0.0342574 |
| EZR | ezrin | -0.0341302 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0338899 |
| RPS6 | ribosomal protein S6 | -0.0321745 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0316117 |
| CALR | calreticulin | -0.0315406 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0313288 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0312918 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0307744 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0302842 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.028391 |
| DIAPH3 | diaphanous-related formin 3 | -0.0281292 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0275346 |
| EGR1 | early growth response 1 | -0.0270679 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0268392 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0267275 |
| RPL37A | ribosomal protein L37a | -0.0264086 |
| GOLGA4 | golgin A4 | -0.0263546 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0257948 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0254135 |
| RPL32 | ribosomal protein L32 | -0.0248661 |
| RPL12 | ribosomal protein L12 | -0.0245599 |
| RPLP1 | ribosomal protein, large, P1 | -0.0242002 |
| MORF4L2 | mortality factor 4 like 2 | -0.0241912 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0240856 |
| AHI1 | Abelson helper integration site 1 | -0.0240087 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0238252 |
| AGR2 | anterior gradient 2 | -0.0233078 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0229618 |
| RPS19 | ribosomal protein S19 | -0.0225574 |
| CCNL1 | cyclin L1 | -0.0225286 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0221315 |
| S100A10 | S100 calcium binding protein A10 | -0.0221211 |
| RPL36A | ribosomal protein L36a | -0.0218506 |
| TMEM263 | transmembrane protein 263 | -0.0217279 |
| MKI67 | marker of proliferation Ki-67 | -0.0212458 |
| CALU | calumenin | -0.0210711 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0210386 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0210014 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0205165 |
| FDPS | farnesyl diphosphate synthase | -0.0203766 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0203302 |
| SEC24D | SEC24 family member D | -0.0199674 |
| CENPF | centromere protein F, 350/400kDa | -0.0199031 |
| RPS23 | ribosomal protein S23 | -0.0198913 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0197957 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0197748 |
| GNAS | GNAS complex locus | -0.019725 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0194908 |
| VIM | vimentin | -0.019479 |
| RPL28 | ribosomal protein L28 | -0.0193209 |
| SSR1 | signal sequence receptor, alpha | -0.0192632 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.019008 |
| SEC24A | SEC24 family member A | -0.0185336 |
| KLHL24 | kelch-like family member 24 | -0.0185116 |
| RRBP1 | ribosome binding protein 1 | -0.018318 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0182416 |
| RPS29 | ribosomal protein S29 | -0.0181995 |
| HMGB2 | high mobility group box 2 | -0.0179659 |
| RPS15 | ribosomal protein S15 | -0.0177587 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.017724 |
| NUCB2 | nucleobindin 2 | -0.0174659 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0174076 |
| BRCA2 | breast cancer 2, early onset | -0.0172639 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0168957 |
| PTEN | phosphatase and tensin homolog | -0.0168693 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0168162 |
| RPLP2 | ribosomal protein, large, P2 | -0.0167835 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0165449 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0164969 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0164916 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0162421 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0162037 |
| SERP1 | stress-associated endoplasmic reticulum protein 1 | -0.0161907 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.016021 |
| SRP54 | signal recognition particle 54kDa | -0.0156941 |
| ADM | adrenomedullin | -0.0156846 |
| H1-0 | H1.0 linker histone | -0.015394 |
| RNF149 | ring finger protein 149 | -0.0153904 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.0152814 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0152766 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0151746 |
| HBP1 | HMG-box transcription factor 1 | -0.0149525 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0148427 |
| FNBP1L | formin binding protein 1-like | -0.0147834 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0146946 |
