LY-2584702 (tosylate salt)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY-2584702 (tosylate salt) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY-2584702 (tosylate salt)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.251461
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.165256
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.146121
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.117681
PABPC1 poly(A) binding protein, cytoplasmic 1 0.117425
LDHA lactate dehydrogenase A 0.0753318
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0670499
KTN1 kinectin 1 (kinesin receptor) 0.0597506
FTL ferritin, light polypeptide 0.0511468
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0504629
MYH9 myosin, heavy chain 9, non-muscle 0.0475855
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.047151
APLP2 amyloid beta (A4) precursor-like protein 2 0.045196
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0429121
GOLGA4 golgin A4 0.0427437
BBX bobby sox homolog (Drosophila) 0.0427011
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0414105
SRRM2 serine/arginine repetitive matrix 2 0.0413523
KRT18 keratin 18, type I 0.0408721
INTS6 integrator complex subunit 6 0.0388996
EPCAM epithelial cell adhesion molecule 0.0384325
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0363341
AKAP9 A kinase (PRKA) anchor protein 9 0.0359622
EEF2 eukaryotic translation elongation factor 2 0.0349422
BRD2 bromodomain containing 2 0.0347425
HSPA8 heat shock 70kDa protein 8 0.0346899
EIF1 eukaryotic translation initiation factor 1 0.0336031
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0333985
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.033299
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0326191
LOC102724023 ES1 protein homolog, mitochondrial 0.0325964
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.032398
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0321859
TTC3 tetratricopeptide repeat domain 3 0.0321097
ZNF638 zinc finger protein 638 0.0317255
RIOK3 RIO kinase 3 0.0313576
HDLBP high density lipoprotein binding protein 0.0312556
PCM1 pericentriolar material 1 0.0307815
RPS6 ribosomal protein S6 0.030338
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.030099
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0293441
PAPOLA poly(A) polymerase alpha 0.0288342
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0287787
S100A10 S100 calcium binding protein A10 0.0287581
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0282387
KMT2C lysine (K)-specific methyltransferase 2C 0.0279227
CANX calnexin 0.0273029
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0267293
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0264938
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0263849
UBC ubiquitin C 0.0263772
RPL5 ribosomal protein L5 0.026121
ASPH aspartate beta-hydroxylase 0.0260529
SRSF11 serine/arginine-rich splicing factor 11 0.025867
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0258268
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0256578
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0253276
GOLGB1 golgin B1 0.0252376
LOC112694756 uncharaterized LOC112694756 0.0251909
LMAN1 lectin, mannose-binding, 1 0.025037
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0247737
CEP350 centrosomal protein 350kDa 0.0246557
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0244574
C11ORF58 chromosome 11 open reading frame 58 0.0244442
TMF1 TATA element modulatory factor 1 0.0240596
PRRC2C proline-rich coiled-coil 2C 0.0238769
TPI1 triosephosphate isomerase 1 0.0238711
ENO1 enolase 1, (alpha) 0.0238481
CEMIP2 cell migration inducing hyaluronidase 2 0.0237656
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.023315
SFPQ splicing factor proline/glutamine-rich 0.0232033
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0231289
SET SET nuclear proto-oncogene 0.0229502
ANXA2 annexin A2 0.022835
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0228282
SAMD4A sterile alpha motif domain containing 4A 0.0227041
EIF5 eukaryotic translation initiation factor 5 0.022505
SRRM1 serine/arginine repetitive matrix 1 0.0222515
WWC2 WW and C2 domain containing 2 0.0222358
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0221206
PDIA6 protein disulfide isomerase family A, member 6 0.0220937
SON SON DNA binding protein 0.0220096
AFF4 AF4/FMR2 family, member 4 0.0217778
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0216652
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0215785
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0215731
ARFGEF3 ARFGEF family member 3 0.0215351
SEC24A SEC24 family member A 0.0214677
RACK1 receptor for activated C kinase 1 0.0214396
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0211359
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0210774
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0210546
COPB1 coatomer protein complex, subunit beta 1 0.0210543
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0209069
PFKP phosphofructokinase, platelet 0.0207854
NAP1L1 nucleosome assembly protein 1-like 1 0.0206708
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0205945
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0205494
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0201787
DSCAM Down syndrome cell adhesion molecule 0.0200261

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.17466
TMSB10 thymosin beta 10 -0.109567
MT2A metallothionein 2A -0.0643871
FAT1 FAT atypical cadherin 1 -0.0516211
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0467922
RPS21 ribosomal protein S21 -0.0404675
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0359213
RPLP2 ribosomal protein, large, P2 -0.0329937
TPT1 tumor protein, translationally-controlled 1 -0.0309538
RPL31 ribosomal protein L31 -0.0300799
RPS24 ribosomal protein S24 -0.0276618
HMGB1 high mobility group box 1 -0.0274572
SMC4 structural maintenance of chromosomes 4 -0.0264396
RPL37A ribosomal protein L37a -0.0263541
RPS23 ribosomal protein S23 -0.0258747
TPM4 tropomyosin 4 -0.0256237
RPL35A ribosomal protein L35a -0.0250378
VIM vimentin -0.0246719
CENPF centromere protein F, 350/400kDa -0.0240647
RPS27A ribosomal protein S27a -0.0233866
ISG15 ISG15 ubiquitin-like modifier -0.0232158
SERINC5 serine incorporator 5 -0.0229399
RPS14 ribosomal protein S14 -0.0226645
RPS19 ribosomal protein S19 -0.0223314
RPL11 ribosomal protein L11 -0.0223196
RPL38 ribosomal protein L38 -0.0215837
CADPS Ca++-dependent secretion activator -0.0213763
RPS17 ribosomal protein S17 -0.0208475
DLG1 discs, large homolog 1 (Drosophila) -0.0202807
DIAPH3 diaphanous-related formin 3 -0.0202325
MYOF myoferlin -0.0191671
NDRG1 N-myc downstream regulated 1 -0.0191078
HOXB3 homeobox B3 -0.0187883
RPS11 ribosomal protein S11 -0.0176337
IGFBP4 insulin-like growth factor binding protein 4 -0.017445
EGR1 early growth response 1 -0.0173495
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0171753
KPNB1 karyopherin (importin) beta 1 -0.0171615
HMGA2 high mobility group AT-hook 2 -0.0171476
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0169084
RPL27A ribosomal protein L27a -0.0167731
S100A6 S100 calcium binding protein A6 -0.0166086
RPS29 ribosomal protein S29 -0.0164241
RPS28 ribosomal protein S28 -0.0161068
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0159977
ACTG1 actin gamma 1 -0.0159856
FDPS farnesyl diphosphate synthase -0.0158509
MT1E metallothionein 1E -0.0158108
CCND1 cyclin D1 -0.0157743
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0157623
ENO2 enolase 2 (gamma, neuronal) -0.015454
ITGB4 integrin, beta 4 -0.0154427
CENPE centromere protein E, 312kDa -0.0153232
UQCRH ubiquinol-cytochrome c reductase hinge protein -0.0152591
MKI67 marker of proliferation Ki-67 -0.014998
PDE4D phosphodiesterase 4D, cAMP-specific -0.0146838
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0146354
TMEM87A transmembrane protein 87A -0.0145343
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.014465
RPS13 ribosomal protein S13 -0.0141186
PA2G4 proliferation-associated 2G4, 38kDa -0.0140947
RRM2 ribonucleotide reductase M2 -0.0139295
MSI2 musashi RNA-binding protein 2 -0.0137097
POTEF POTE ankyrin domain family, member F -0.013652
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0136083
IFI6 interferon, alpha-inducible protein 6 -0.0135152
HMGB2 high mobility group box 2 -0.0133475
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 -0.0132791
ANLN anillin, actin binding protein -0.0129721
MORF4L1 mortality factor 4 like 1 -0.0128568
SPIDR scaffolding protein involved in DNA repair -0.0128297
RAD51B RAD51 paralog B -0.0127595
BACE2 beta-site APP-cleaving enzyme 2 -0.0127119
RPLP1 ribosomal protein, large, P1 -0.0125044
NSD2 nuclear receptor binding SET domain protein 2 -0.0124508
RPL9 ribosomal protein L9 -0.0122464
ADGRE5 adhesion G protein-coupled receptor E5 -0.0122409
ACACA acetyl-CoA carboxylase alpha -0.0121372
FBXL2 F-box and leucine-rich repeat protein 2 -0.0121163
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0120738
RNF43 ring finger protein 43 -0.0119923
TUBB tubulin, beta class I -0.0119715
SNU13 small nuclear ribonucleoprotein 13 -0.0119059
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0118744
EFNA5 ephrin-A5 -0.011817
ARF4 ADP-ribosylation factor 4 -0.0116317
SRPK2 SRSF protein kinase 2 -0.0116104
MORC4 MORC family CW-type zinc finger 4 -0.0115691
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0114905
GATAD2B GATA zinc finger domain containing 2B -0.0114743
EFHD2 EF-hand domain family, member D2 -0.0114665
ACTN4 actinin, alpha 4 -0.0113442
PFN1 profilin 1 -0.0113427
CUTA cutA divalent cation tolerance homolog (E. coli) -0.0113017
HPCAL1 hippocalcin-like 1 -0.0111656
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0111427
RPL19 ribosomal protein L19 -0.0110862
TUBB4B tubulin, beta 4B class IVb -0.0110598
DMXL1 Dmx-like 1 -0.0108299
ZNF33A zinc finger protein 33A -0.0107903