| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.553786 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.178416 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.120361 |
| CD44 | CD44 molecule (Indian blood group) | 0.112269 |
| LDHA | lactate dehydrogenase A | 0.0979632 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0900924 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0615854 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0614493 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0580266 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0569621 |
| SEPTIN9 | septin 9 | 0.0548296 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0526542 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0519694 |
| FTL | ferritin, light polypeptide | 0.0487772 |
| SMAD3 | SMAD family member 3 | 0.0460948 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0428778 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.042073 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0413895 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0413356 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0407416 |
| G0S2 | G0/G1 switch 2 | 0.0398908 |
| EMP1 | epithelial membrane protein 1 | 0.0393278 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0379328 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0371872 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0367662 |
| RPL12 | ribosomal protein L12 | 0.0363651 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0362267 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0351844 |
| PKM | pyruvate kinase, muscle | 0.0349545 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0348958 |
| PTK2 | protein tyrosine kinase 2 | 0.0345765 |
| MSN | moesin | 0.0345101 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0343893 |
| TXNIP | thioredoxin interacting protein | 0.0325975 |
| DTNA | dystrobrevin, alpha | 0.0324058 |
| RPL30 | ribosomal protein L30 | 0.0319565 |
| ANXA2 | annexin A2 | 0.0317622 |
| UBC | ubiquitin C | 0.0311526 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0311038 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0309549 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0302879 |
| ANGPTL4 | angiopoietin-like 4 | 0.0302552 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0298673 |
| ADM | adrenomedullin | 0.0298231 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0292582 |
| NAV1 | neuron navigator 1 | 0.0291946 |
| NAV2 | neuron navigator 2 | 0.0286789 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0279801 |
| PLEC | plectin | 0.0279039 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0273352 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0272103 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0270968 |
| S100A10 | S100 calcium binding protein A10 | 0.0266612 |
| RPLP1 | ribosomal protein, large, P1 | 0.0266217 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0260739 |
| FAT1 | FAT atypical cadherin 1 | 0.0257102 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0255787 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0251163 |
| CLIC4 | chloride intracellular channel 4 | 0.0250126 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0248381 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0246157 |
| TGFB1 | transforming growth factor, beta 1 | 0.0245082 |
| RPS4X | ribosomal protein S4, X-linked | 0.0244778 |
| MCL1 | myeloid cell leukemia 1 | 0.0242664 |
| DUSP6 | dual specificity phosphatase 6 | 0.0242585 |
| RPL23 | ribosomal protein L23 | 0.024002 |
| CAPRIN2 | caprin family member 2 | 0.0238881 |
| LOXL2 | lysyl oxidase-like 2 | 0.0237485 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.023679 |
| ASPH | aspartate beta-hydroxylase | 0.0236156 |
| RCOR1 | REST corepressor 1 | 0.0235956 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0233513 |
| NDRG1 | N-myc downstream regulated 1 | 0.0232124 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0228851 |
| LMNA | lamin A/C | 0.0224862 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0224386 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0222082 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0220526 |
| RPS2 | ribosomal protein S2 | 0.0220277 |
| MYO9B | myosin IXB | 0.0219374 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0218322 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0216263 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0213911 |
| FAM13A | family with sequence similarity 13, member A | 0.0213625 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0213137 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0211053 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0210767 |
| RPL7 | ribosomal protein L7 | 0.0209943 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0209558 |
| RPS6 | ribosomal protein S6 | 0.0208374 |
| ZNF638 | zinc finger protein 638 | 0.0204839 |
| CTSB | cathepsin B | 0.0202321 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0198329 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0190647 |
| APP | amyloid beta (A4) precursor protein | 0.0190322 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0185647 |
| RPLP0 | ribosomal protein, large, P0 | 0.0185604 |
| FLNA | filamin A, alpha | 0.0184952 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0184724 |
| SGMS2 | sphingomyelin synthase 2 | 0.0184199 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.205805 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.155657 |
| IGF2 | insulin-like growth factor 2 | -0.107073 |
| CDH13 | cadherin 13 | -0.0993754 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0856229 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0783935 |
| TMSB10 | thymosin beta 10 | -0.0740701 |
| VIM | vimentin | -0.0669675 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0520531 |
| VCL | vinculin | -0.0469404 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0456217 |
| PTMA | prothymosin, alpha | -0.0453809 |
| FMN1 | formin 1 | -0.0436943 |
| CANX | calnexin | -0.042331 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0418542 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.041074 |
| RPS29 | ribosomal protein S29 | -0.0401921 |
| TPM4 | tropomyosin 4 | -0.0367816 |
| INHBA | inhibin, beta A | -0.032655 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0315198 |
| RPL37A | ribosomal protein L37a | -0.0302173 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.030143 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0296083 |
| COL1A1 | collagen, type I, alpha 1 | -0.0295068 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0286359 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0282768 |
| PDE10A | phosphodiesterase 10A | -0.0280856 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0280102 |
| CLMP | CXADR-like membrane protein | -0.0271911 |
| AHNAK | AHNAK nucleoprotein | -0.0257643 |
| CALD1 | caldesmon 1 | -0.0255476 |
| LAMB3 | laminin, beta 3 | -0.0254921 |
| RPS25 | ribosomal protein S25 | -0.0247963 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0245618 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.024366 |
| OSMR | oncostatin M receptor | -0.0237834 |
| COL5A1 | collagen, type V, alpha 1 | -0.0236308 |
| HMGA2 | high mobility group AT-hook 2 | -0.023296 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.023074 |
| MT2A | metallothionein 2A | -0.02293 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0228825 |
| TUBB6 | tubulin, beta 6 class V | -0.0228648 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0227563 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0227208 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0224494 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0223628 |
| RPLP2 | ribosomal protein, large, P2 | -0.0222586 |
| PCNX4 | pecanex 4 | -0.0222446 |
| RIN2 | Ras and Rab interactor 2 | -0.0221772 |
| GNAS | GNAS complex locus | -0.0220628 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0220574 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.0215818 |
| ACTG1 | actin gamma 1 | -0.0209714 |
| RPS21 | ribosomal protein S21 | -0.0205683 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0205406 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0203473 |
| CENPF | centromere protein F, 350/400kDa | -0.0202742 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.020144 |
| TMEM263 | transmembrane protein 263 | -0.0192114 |
| HM13 | histocompatibility (minor) 13 | -0.0184727 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0184203 |
| TAOK1 | TAO kinase 1 | -0.0179626 |
| TMEM165 | transmembrane protein 165 | -0.017894 |
| HDLBP | high density lipoprotein binding protein | -0.0173719 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0172159 |
| MMP12 | matrix metallopeptidase 12 | -0.0171018 |
| RRBP1 | ribosome binding protein 1 | -0.0170777 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0170734 |
| PLS3 | plastin 3 | -0.0169896 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0169804 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0169177 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0169111 |
| TNNC1 | troponin C type 1 (slow) | -0.0168971 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0167764 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0166857 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0166255 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0165805 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0164968 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0161998 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.0159056 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0158733 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0158479 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0157523 |
| S100A9 | S100 calcium binding protein A9 | -0.0157159 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0154828 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0153612 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0152324 |
| AAK1 | AP2 associated kinase 1 | -0.0149817 |
| PRR11 | proline rich 11 | -0.0149558 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0149167 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0148943 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0148401 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0148161 |
| CEP95 | centrosomal protein 95kDa | -0.0147571 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0145497 |
| TPM1 | tropomyosin 1 (alpha) | -0.0144187 |
| RPS24 | ribosomal protein S24 | -0.0144165 |
| DIAPH3 | diaphanous-related formin 3 | -0.0143569 |
| MYO9A | myosin IXA | -0.0141881 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0139703 |
