| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.193527 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0885108 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0549752 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0447159 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0416807 |
| LDHA | lactate dehydrogenase A | 0.0404057 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0351193 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0344262 |
| MT2A | metallothionein 2A | 0.0324491 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0323631 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0320418 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0318643 |
| CALU | calumenin | 0.029668 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0292638 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0270234 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0267064 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0260861 |
| LOX | lysyl oxidase | 0.0244285 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.023783 |
| SP100 | SP100 nuclear antigen | 0.0231635 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.023057 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0222651 |
| UBC | ubiquitin C | 0.0222054 |
| PRELID2 | PRELI domain containing 2 | 0.0221845 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0220571 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0219959 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0216325 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0211767 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0210293 |
| IL6ST | interleukin 6 signal transducer | 0.0209823 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0204118 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0199999 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0197301 |
| RPS3 | ribosomal protein S3 | 0.0197119 |
| ATXN1 | ataxin 1 | 0.0193422 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0192781 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0190994 |
| CLTC | clathrin, heavy chain (Hc) | 0.0187237 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0185958 |
| SMAD3 | SMAD family member 3 | 0.0181643 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0178067 |
| RPL7 | ribosomal protein L7 | 0.0177428 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0173037 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.017273 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0172548 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.017162 |
| FAM107B | family with sequence similarity 107, member B | 0.0169579 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.016841 |
| NAV2 | neuron navigator 2 | 0.0165681 |
| GOLGB1 | golgin B1 | 0.0165647 |
| TLE4 | transducin-like enhancer of split 4 | 0.0165541 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0163554 |
| FAT1 | FAT atypical cadherin 1 | 0.0161604 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0160726 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0157944 |
| ASPH | aspartate beta-hydroxylase | 0.0155985 |
| DST | dystonin | 0.0155806 |
| FBN1 | fibrillin 1 | 0.0155342 |
| INTS6 | integrator complex subunit 6 | 0.0154734 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0153938 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0152569 |
| RPL11 | ribosomal protein L11 | 0.0151819 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0151086 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0150154 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0150141 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0150073 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0148983 |
| INHBA | inhibin, beta A | 0.0146212 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0145458 |
| MX2 | MX dynamin-like GTPase 2 | 0.0145065 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.014433 |
| ARRDC3 | arrestin domain containing 3 | 0.014312 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0138407 |
| HDAC9 | histone deacetylase 9 | 0.0138269 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0137801 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0137762 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0137377 |
| RIGI | RNA sensor RIG-I | 0.0136895 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0136489 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0135992 |
| CAVIN1 | caveolae associated protein 1 | 0.0135924 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0135527 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0135245 |
| PTK2 | protein tyrosine kinase 2 | 0.0134932 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0134806 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0133818 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0133054 |
| AHI1 | Abelson helper integration site 1 | 0.0132822 |
| SEC24D | SEC24 family member D | 0.0132793 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0132274 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0132084 |
| POSTN | periostin, osteoblast specific factor | 0.0128942 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0128437 |
| APP | amyloid beta (A4) precursor protein | 0.0126682 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0126629 |
| PALLD | palladin, cytoskeletal associated protein | 0.0126045 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0124782 |
| PGM3 | phosphoglucomutase 3 | 0.0122621 |
| SQLE | squalene epoxidase | 0.0122259 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0121433 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.11275 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0993958 |
| TMSB10 | thymosin beta 10 | -0.0983096 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0980998 |
| NDRG1 | N-myc downstream regulated 1 | -0.0882149 |
| COL1A2 | collagen, type I, alpha 2 | -0.0834103 |
| COL1A1 | collagen, type I, alpha 1 | -0.073004 |
| RPL35A | ribosomal protein L35a | -0.0586294 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0567343 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0553797 |
| PTMA | prothymosin, alpha | -0.0520877 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.04445 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0441419 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0432182 |
| VEGFA | vascular endothelial growth factor A | -0.0427684 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0412221 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0380075 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0342026 |
| TPM4 | tropomyosin 4 | -0.0338896 |
| S100A9 | S100 calcium binding protein A9 | -0.0325925 |
| IER3 | immediate early response 3 | -0.0317212 |
| S100A6 | S100 calcium binding protein A6 | -0.0307071 |
| STC1 | stanniocalcin 1 | -0.030535 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0300282 |
| FTL | ferritin, light polypeptide | -0.029699 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0277833 |
| HLA-A | major histocompatibility complex, class I, A | -0.0271367 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0270637 |
| RPS6 | ribosomal protein S6 | -0.026737 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0252525 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0229339 |
| HLA-B | major histocompatibility complex, class I, B | -0.0218661 |
| POTEF | POTE ankyrin domain family, member F | -0.0216982 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0213386 |
| RPLP1 | ribosomal protein, large, P1 | -0.0200713 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0199355 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0192909 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0175981 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0174609 |
| COL7A1 | collagen, type VII, alpha 1 | -0.017414 |
| TMEM165 | transmembrane protein 165 | -0.0171844 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0171662 |
| CST3 | cystatin C | -0.017064 |
| RPS8 | ribosomal protein S8 | -0.0168354 |
| PDE10A | phosphodiesterase 10A | -0.016324 |
| GNAS | GNAS complex locus | -0.0158565 |
| RPL34 | ribosomal protein L34 | -0.0158139 |
| TPM2 | tropomyosin 2 (beta) | -0.0156987 |
| CLMP | CXADR-like membrane protein | -0.0152463 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0144596 |
| COL5A1 | collagen, type V, alpha 1 | -0.0143678 |
| IL6 | interleukin 6 | -0.0139832 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.01354 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0134117 |
| RTN4 | reticulon 4 | -0.013358 |
| CD99 | CD99 molecule | -0.0132806 |
| FBXO11 | F-box protein 11 | -0.0130622 |
| SEPTIN7 | septin 7 | -0.0129941 |
| MATR3 | matrin 3 | -0.012904 |
| RPS14 | ribosomal protein S14 | -0.0128851 |
| SMIM44 | small integral membrane protein 44 | -0.012868 |
| YBX1 | Y box binding protein 1 | -0.0125707 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0123065 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.0122783 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0121381 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0120975 |
| TPM1 | tropomyosin 1 (alpha) | -0.012005 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0119697 |
| NUCB2 | nucleobindin 2 | -0.0117695 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0117571 |
| SEC61G | Sec61 gamma subunit | -0.0116641 |
| PXDN | peroxidasin | -0.0116049 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0115029 |
| C1R | complement component 1, r subcomponent | -0.0114683 |
| HAS2 | hyaluronan synthase 2 | -0.0114092 |
| RPS19 | ribosomal protein S19 | -0.011409 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0113066 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0111168 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0111016 |
| PFN1 | profilin 1 | -0.0110683 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0109953 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0109829 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0109676 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0109593 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0109461 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0109441 |
| ACTG1 | actin gamma 1 | -0.010758 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0107366 |
| VCAN | versican | -0.0106981 |
| ADM | adrenomedullin | -0.0106831 |
| EGR1 | early growth response 1 | -0.0106079 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0105999 |
| KIF13A | kinesin family member 13A | -0.0105717 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0104805 |
| TGFB1 | transforming growth factor, beta 1 | -0.0104749 |
| CMIP | c-Maf inducing protein | -0.0104481 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0103846 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0103467 |
| S100A11 | S100 calcium binding protein A11 | -0.0102438 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0101609 |
