| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | 0.292504 |
| LMO7 | LIM domain 7 | 0.173014 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.164691 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.154356 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.129556 |
| EXT1 | exostosin glycosyltransferase 1 | 0.121518 |
| ATXN1 | ataxin 1 | 0.0982914 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0980024 |
| SMAD3 | SMAD family member 3 | 0.0964964 |
| RPL23 | ribosomal protein L23 | 0.0872198 |
| TJP1 | tight junction protein 1 | 0.0853291 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0815108 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0796376 |
| PDZD8 | PDZ domain containing 8 | 0.0780845 |
| LDHA | lactate dehydrogenase A | 0.074511 |
| NTN4 | netrin 4 | 0.0740983 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0723021 |
| TXNRD1 | thioredoxin reductase 1 | 0.0722748 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0687042 |
| RPL21 | ribosomal protein L21 | 0.0682746 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0674951 |
| RPS6 | ribosomal protein S6 | 0.0672053 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0653204 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0648242 |
| S100A10 | S100 calcium binding protein A10 | 0.0639143 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0629625 |
| RPS3 | ribosomal protein S3 | 0.0629259 |
| RPL27A | ribosomal protein L27a | 0.0614325 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0611124 |
| UBC | ubiquitin C | 0.0606823 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0605487 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0595471 |
| RPL18 | ribosomal protein L18 | 0.0586987 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0583529 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.058192 |
| DST | dystonin | 0.0572434 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0566229 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0561536 |
| RPLP0 | ribosomal protein, large, P0 | 0.0560511 |
| RPS8 | ribosomal protein S8 | 0.0557513 |
| B2M | beta-2-microglobulin | 0.05552 |
| TMEM123 | transmembrane protein 123 | 0.0553787 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0552039 |
| RPS5 | ribosomal protein S5 | 0.0548847 |
| ANKRD12 | ankyrin repeat domain 12 | 0.054712 |
| EPCAM | epithelial cell adhesion molecule | 0.0543429 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0531855 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0527313 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0508097 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0504672 |
| RPL8 | ribosomal protein L8 | 0.0495556 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0481243 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0474203 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0471683 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0471292 |
| EREG | epiregulin | 0.0470883 |
| FOXP1 | forkhead box P1 | 0.0454822 |
| KRT18 | keratin 18, type I | 0.0452879 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0451125 |
| CD2AP | CD2-associated protein | 0.0447721 |
| GOLGA4 | golgin A4 | 0.044747 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.044244 |
| JMJD1C | jumonji domain containing 1C | 0.0436346 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0433752 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0429831 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0428455 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0426294 |
| PGK1 | phosphoglycerate kinase 1 | 0.0426278 |
| TPI1 | triosephosphate isomerase 1 | 0.0426151 |
| PTK2 | protein tyrosine kinase 2 | 0.0424422 |
| TMC5 | transmembrane channel-like 5 | 0.0423422 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.042272 |
| RACK1 | receptor for activated C kinase 1 | 0.0420404 |
| KLF6 | Kruppel-like factor 6 | 0.0417685 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0416301 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0398491 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0390658 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.039038 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0383535 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0381475 |
| LYZ | lysozyme | 0.0378608 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0378311 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.037789 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0374494 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0373463 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0373111 |
| TMEM65 | transmembrane protein 65 | 0.0372695 |
| DSTN | destrin (actin depolymerizing factor) | 0.0371243 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0369988 |
| EXPH5 | exophilin 5 | 0.0367972 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.036702 |
| PLK2 | polo-like kinase 2 | 0.0364875 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0360674 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0358035 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0355225 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0353861 |
| ERBIN | erbb2 interacting protein | 0.0353499 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0353182 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0350335 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0350159 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0764276 |
| LAMA4 | laminin, alpha 4 | -0.0725924 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0634654 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0490793 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0482559 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0449346 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0443675 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.038677 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.037676 |
| ACTN4 | actinin, alpha 4 | -0.0365319 |
| AHNAK | AHNAK nucleoprotein | -0.0351603 |
| RPS29 | ribosomal protein S29 | -0.0338914 |
| TMSB10 | thymosin beta 10 | -0.0337276 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0333059 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0331677 |
| NDRG1 | N-myc downstream regulated 1 | -0.0331002 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0318132 |
| KRT20 | keratin 20, type I | -0.0296955 |
| FRY | furry homolog (Drosophila) | -0.0281821 |
| VIM | vimentin | -0.0279074 |
| EGR1 | early growth response 1 | -0.0274886 |
| GSN | gelsolin | -0.0273483 |
| RPL36 | ribosomal protein L36 | -0.0263586 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.026108 |
| RPL38 | ribosomal protein L38 | -0.0260694 |
| RPLP2 | ribosomal protein, large, P2 | -0.0255005 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0249849 |
| RPL36A | ribosomal protein L36a | -0.0246777 |
| S100P | S100 calcium binding protein P | -0.0228815 |
| DUSP5 | dual specificity phosphatase 5 | -0.0228807 |
| MT2A | metallothionein 2A | -0.0224888 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0216449 |
| MCL1 | myeloid cell leukemia 1 | -0.021614 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0215968 |
| ZFP36 | ZFP36 ring finger protein | -0.0215622 |
| EZR | ezrin | -0.0212915 |
| LSR | lipolysis stimulated lipoprotein receptor | -0.0207866 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0207457 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0205911 |
| PTPRH | protein tyrosine phosphatase, receptor type, H | -0.0203039 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0200933 |
| JUP | junction plakoglobin | -0.0192299 |
| MMP7 | matrix metallopeptidase 7 | -0.0191736 |
| ANXA2 | annexin A2 | -0.0190253 |
| RBM39 | RNA binding motif protein 39 | -0.0189943 |
| RDH13 | retinol dehydrogenase 13 (all-trans/9-cis) | -0.0189297 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0189173 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0188795 |
| PRELID2 | PRELI domain containing 2 | -0.0184798 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0179818 |
| SDC4 | syndecan 4 | -0.0179272 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.017517 |
| PLEC | plectin | -0.0174261 |
| CAPN8 | calpain 8 | -0.017291 |
| PCED1B | PC-esterase domain containing 1B | -0.0169501 |
| AGR2 | anterior gradient 2 | -0.016188 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0160416 |
| RAB2A | RAB2A, member RAS oncogene family | -0.015997 |
| HM13 | histocompatibility (minor) 13 | -0.015775 |
| KCNK6 | potassium channel, two pore domain subfamily K, member 6 | -0.0157144 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0155542 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0146009 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0145274 |
| RPS10 | ribosomal protein S10 | -0.0144956 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0143207 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0142711 |
| LDLR | low density lipoprotein receptor | -0.0141544 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0138385 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0136783 |
| PPL | periplakin | -0.0136457 |
| INSIG1 | insulin induced gene 1 | -0.0135819 |
| NPSR1 | neuropeptide S receptor 1 | -0.0135394 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0134856 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | -0.013324 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0132481 |
| SQSTM1 | sequestosome 1 | -0.0131821 |
| VASP | vasodilator-stimulated phosphoprotein | -0.0131319 |
| EPS8L2 | EPS8-like 2 | -0.0131274 |
| ADD1 | adducin 1 (alpha) | -0.012862 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0127392 |
| CEP95 | centrosomal protein 95kDa | -0.0126975 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0126326 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0126119 |
| ABHD12 | abhydrolase domain containing 12 | -0.0124992 |
| S100A11 | S100 calcium binding protein A11 | -0.0123766 |
| EPHA2 | EPH receptor A2 | -0.0123036 |
| RPL37A | ribosomal protein L37a | -0.012298 |
| RPL36AL | ribosomal protein L36a-like | -0.0121121 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0120457 |
| WASF2 | WAS protein family, member 2 | -0.0118674 |
| HLA-B | major histocompatibility complex, class I, B | -0.0116798 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0116721 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0116521 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0115828 |
| RPS27A | ribosomal protein S27a | -0.0115777 |
| ADIPOR2 | adiponectin receptor 2 | -0.0114458 |
| ARF4 | ADP-ribosylation factor 4 | -0.0114006 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.01137 |
| RAD51B | RAD51 paralog B | -0.011343 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0112722 |
