| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.205649 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.133411 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0970225 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0678994 |
| GPC6 | glypican 6 | 0.063954 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0489318 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0480257 |
| EHBP1 | EH domain binding protein 1 | 0.0461781 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0441865 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0416064 |
| ATXN1 | ataxin 1 | 0.0412925 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0410001 |
| FRMD5 | FERM domain containing 5 | 0.0402145 |
| ASPH | aspartate beta-hydroxylase | 0.0397711 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0397444 |
| SLC38A2 | solute carrier family 38, member 2 | 0.039038 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.038355 |
| SVIL | supervillin | 0.0383046 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0355602 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0353218 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.033327 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0319494 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0289424 |
| RNF213 | ring finger protein 213 | 0.0280652 |
| FOXP1 | forkhead box P1 | 0.0278945 |
| RPL37A | ribosomal protein L37a | 0.0274347 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.027248 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.026809 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0262991 |
| RIGI | RNA sensor RIG-I | 0.024933 |
| PTCHD4 | patched domain containing 4 | 0.0244961 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0241925 |
| FAM135A | family with sequence similarity 135, member A | 0.0237659 |
| APOA2 | apolipoprotein A-II | 0.0237098 |
| FAT1 | FAT atypical cadherin 1 | 0.0236992 |
| AHR | aryl hydrocarbon receptor | 0.0232326 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0219446 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0218919 |
| CP | ceruloplasmin (ferroxidase) | 0.0218857 |
| OSMR | oncostatin M receptor | 0.0215732 |
| RPS29 | ribosomal protein S29 | 0.0208574 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0206572 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0205771 |
| RPLP2 | ribosomal protein, large, P2 | 0.0205661 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0200391 |
| ACTG1 | actin gamma 1 | 0.0199667 |
| RPL31 | ribosomal protein L31 | 0.0198911 |
| ITGAV | integrin, alpha V | 0.0198371 |
| STK39 | serine threonine kinase 39 | 0.0197283 |
| GRB10 | growth factor receptor-bound protein 10 | 0.019636 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0189297 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0189161 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0188996 |
| FHIT | fragile histidine triad | 0.0186966 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.018605 |
| NHSL1 | NHS-like 1 | 0.0185512 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0182866 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0179879 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0178858 |
| RAD51B | RAD51 paralog B | 0.01774 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0172591 |
| RPS23 | ribosomal protein S23 | 0.0172005 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0170339 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0169912 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0168868 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0168499 |
| KYNU | kynureninase | 0.0166248 |
| SP100 | SP100 nuclear antigen | 0.0165278 |
| FILIP1L | filamin A interacting protein 1-like | 0.0161886 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0156811 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0155138 |
| VCL | vinculin | 0.0151707 |
| FRK | fyn-related Src family tyrosine kinase | 0.0151662 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0148872 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0147967 |
| VCAN | versican | 0.0147273 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0147263 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0147079 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0145342 |
| MYO1E | myosin IE | 0.0144934 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0144358 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0144139 |
| JMJD1C | jumonji domain containing 1C | 0.0144017 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0143408 |
| MX1 | MX dynamin-like GTPase 1 | 0.0141487 |
| ITGA6 | integrin, alpha 6 | 0.0140597 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0139594 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0138658 |
| MRTFA | myocardin related transcription factor A | 0.0136952 |
| KRT23 | keratin 23, type I | 0.0136053 |
| SPATA13 | spermatogenesis associated 13 | 0.0135479 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0135243 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0131897 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0131897 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0131556 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.013137 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0130918 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.013086 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0130286 |
| RPL7A | ribosomal protein L7a | 0.0130235 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.303378 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.2115 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.162611 |
| C3 | complement component 3 | -0.131658 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.119402 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0783004 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0733118 |
| GPC3 | glypican 3 | -0.0719932 |
| ENO1 | enolase 1, (alpha) | -0.0708928 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0614517 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0614106 |
| APOB | apolipoprotein B | -0.0605165 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0544695 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0508073 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0468728 |
| PCBP2 | poly(rC) binding protein 2 | -0.0442853 |
| RPLP1 | ribosomal protein, large, P1 | -0.0440208 |
| SDC4 | syndecan 4 | -0.0433643 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0405676 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.039705 |
| GOLGA4 | golgin A4 | -0.0391418 |
| UBC | ubiquitin C | -0.0381153 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0346707 |
| RPS27A | ribosomal protein S27a | -0.034543 |
| VEGFA | vascular endothelial growth factor A | -0.0343174 |
| LDHA | lactate dehydrogenase A | -0.0330633 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0329891 |
| MATR3 | matrin 3 | -0.0327497 |
| NDRG1 | N-myc downstream regulated 1 | -0.0324985 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0322661 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.0321347 |
| FTL | ferritin, light polypeptide | -0.0320051 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0319564 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0316344 |
| YBX1 | Y box binding protein 1 | -0.0314001 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0309497 |
| TRIM26 | tripartite motif containing 26 | -0.0303239 |
| JUN | jun proto-oncogene | -0.0296115 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0295915 |
| RPS6 | ribosomal protein S6 | -0.0295686 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0295227 |
| APOE | apolipoprotein E | -0.0295121 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0292697 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0292232 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0291133 |
| RPL12 | ribosomal protein L12 | -0.0285724 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0279599 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0279061 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0265935 |
| WDR45B | WD repeat domain 45B | -0.0265499 |
| PKM | pyruvate kinase, muscle | -0.026346 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0263078 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0259261 |
| GNAS | GNAS complex locus | -0.0258533 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0258095 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0255955 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0253639 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0248885 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0248792 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.0245596 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0237191 |
| RBM25 | RNA binding motif protein 25 | -0.0236338 |
| PTMA | prothymosin, alpha | -0.0234845 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0234546 |
| AHNAK | AHNAK nucleoprotein | -0.0234104 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0233932 |
| ZNF207 | zinc finger protein 207 | -0.0233767 |
| CPE | carboxypeptidase E | -0.0229828 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0229276 |
| CST3 | cystatin C | -0.0226535 |
| OGA | O-GlcNAcase | -0.022635 |
| HDLBP | high density lipoprotein binding protein | -0.0225803 |
| TMEM123 | transmembrane protein 123 | -0.0224846 |
| LYZ | lysozyme | -0.0224413 |
| PEG10 | paternally expressed 10 | -0.0223349 |
| TOP1 | topoisomerase (DNA) I | -0.0217859 |
| MALT1 | MALT1 paracaspase | -0.0217374 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0212585 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0211069 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0211006 |
| PDE8A | phosphodiesterase 8A | -0.0209101 |
| HELZ | helicase with zinc finger | -0.020881 |
| CANX | calnexin | -0.0207991 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0207831 |
| CALR | calreticulin | -0.0206629 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0205493 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0205287 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0204152 |
| PHKB | phosphorylase kinase, beta | -0.0203393 |
| WWC2 | WW and C2 domain containing 2 | -0.0203356 |
| APOA1 | apolipoprotein A-I | -0.0201999 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0201626 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0198828 |
| QKI | QKI, KH domain containing, RNA binding | -0.0198681 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0198648 |
| GLG1 | golgi glycoprotein 1 | -0.0197564 |
| RPL34 | ribosomal protein L34 | -0.0196477 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0195678 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0195665 |
| MT1X | metallothionein 1X | -0.0194061 |
