| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.164901 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.122593 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.116842 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0843857 |
| MT2A | metallothionein 2A | 0.0774874 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0722858 |
| LDHA | lactate dehydrogenase A | 0.0716676 |
| FTL | ferritin, light polypeptide | 0.0578041 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0572743 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0564667 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0522867 |
| B2M | beta-2-microglobulin | 0.0499581 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0469989 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0455888 |
| MKI67 | marker of proliferation Ki-67 | 0.0413247 |
| TLE4 | transducin-like enhancer of split 4 | 0.040885 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0396826 |
| PTK2 | protein tyrosine kinase 2 | 0.0382524 |
| DEK | DEK proto-oncogene | 0.0367756 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0364041 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0360816 |
| ANXA1 | annexin A1 | 0.0360761 |
| GOLGB1 | golgin B1 | 0.0353389 |
| MSN | moesin | 0.0350443 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0348238 |
| CD44 | CD44 molecule (Indian blood group) | 0.034036 |
| HLA-E | major histocompatibility complex, class I, E | 0.0335082 |
| KRT8 | keratin 8, type II | 0.0334944 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0306508 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0306042 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0304545 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.03 |
| CLIC4 | chloride intracellular channel 4 | 0.0299857 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0299105 |
| IL6ST | interleukin 6 signal transducer | 0.0289785 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0282958 |
| ZNF841 | zinc finger protein 841 | 0.0281316 |
| SMYD3 | SET and MYND domain containing 3 | 0.0279832 |
| NAV2 | neuron navigator 2 | 0.0273156 |
| ASPH | aspartate beta-hydroxylase | 0.0272058 |
| MT1X | metallothionein 1X | 0.0269474 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0267213 |
| SMAD3 | SMAD family member 3 | 0.026414 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0262101 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0261766 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0258315 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0253993 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0253443 |
| ZNF432 | zinc finger protein 432 | 0.0253383 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0252836 |
| SET | SET nuclear proto-oncogene | 0.0252659 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0249816 |
| UBC | ubiquitin C | 0.0247713 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0246536 |
| HSPA8 | heat shock 70kDa protein 8 | 0.024387 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0241751 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0240543 |
| MCL1 | myeloid cell leukemia 1 | 0.0238439 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0237348 |
| FAM107B | family with sequence similarity 107, member B | 0.0234567 |
| RPL21 | ribosomal protein L21 | 0.0234379 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0232653 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0231002 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | 0.0227883 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0227839 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0227383 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0224965 |
| ACTN1 | actinin, alpha 1 | 0.0217793 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0216396 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0215419 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.02117 |
| INTS6 | integrator complex subunit 6 | 0.0209825 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0208342 |
| ATXN1 | ataxin 1 | 0.0208169 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0206327 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0205823 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0204158 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0203637 |
| RPS2 | ribosomal protein S2 | 0.0202926 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.0202077 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0200784 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0198944 |
| PKP4 | plakophilin 4 | 0.0198378 |
| RPLP0 | ribosomal protein, large, P0 | 0.0198225 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.019761 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.019654 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0194347 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0194014 |
| YBX3 | Y box binding protein 3 | 0.0192876 |
| LMO7 | LIM domain 7 | 0.0192467 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.019185 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0190707 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0189061 |
| RBM25 | RNA binding motif protein 25 | 0.0188986 |
| CLTC | clathrin, heavy chain (Hc) | 0.0188874 |
| RUNX1 | runt-related transcription factor 1 | 0.0188827 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0188351 |
| HEXB | hexosaminidase B (beta polypeptide) | 0.0187294 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0187022 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.018619 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.20455 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.166381 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.108516 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.104626 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0985425 |
| HLA-B | major histocompatibility complex, class I, B | -0.0973867 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0933618 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0782153 |
| PLIN2 | perilipin 2 | -0.0757231 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0729572 |
| VIM | vimentin | -0.0695165 |
| NDRG1 | N-myc downstream regulated 1 | -0.0628496 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0585767 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0519813 |
| TMSB10 | thymosin beta 10 | -0.0501104 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0475402 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0468678 |
| GLIS3 | GLIS family zinc finger 3 | -0.0464362 |
| CTSD | cathepsin D | -0.043466 |
| CANX | calnexin | -0.0427548 |
| ACTG1 | actin gamma 1 | -0.0422377 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0396413 |
| TUBB | tubulin, beta class I | -0.0391349 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0389224 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0385644 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0381888 |
| POTEF | POTE ankyrin domain family, member F | -0.0381365 |
| ATP13A3 | ATPase type 13A3 | -0.0372969 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0360319 |
| RPLP2 | ribosomal protein, large, P2 | -0.0358077 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0353555 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0349715 |
| RPS25 | ribosomal protein S25 | -0.0343809 |
| TGFB2 | transforming growth factor, beta 2 | -0.0343527 |
| PTMA | prothymosin, alpha | -0.0337724 |
| RPS27A | ribosomal protein S27a | -0.033306 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0323038 |
| RPL37A | ribosomal protein L37a | -0.0322629 |
| RPS29 | ribosomal protein S29 | -0.030786 |
| TMEM178B | transmembrane protein 178B | -0.0300649 |
| TPM1 | tropomyosin 1 (alpha) | -0.029955 |
| MAP4 | microtubule-associated protein 4 | -0.0294787 |
| RPL35A | ribosomal protein L35a | -0.0289048 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0281238 |
| POSTN | periostin, osteoblast specific factor | -0.0279815 |
| COL5A2 | collagen, type V, alpha 2 | -0.0279745 |
| MMP12 | matrix metallopeptidase 12 | -0.0279654 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0269222 |
| RPS11 | ribosomal protein S11 | -0.0266435 |
| PLCB4 | phospholipase C, beta 4 | -0.0266364 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0265619 |
| TNS3 | tensin 3 | -0.0263226 |
| RPL36A | ribosomal protein L36a | -0.0253601 |
| RPS24 | ribosomal protein S24 | -0.025343 |
| IER3 | immediate early response 3 | -0.0251258 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0247553 |
| RPS12 | ribosomal protein S12 | -0.0245123 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.024295 |
| COL5A1 | collagen, type V, alpha 1 | -0.0238737 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0232741 |
| RPL31 | ribosomal protein L31 | -0.0229372 |
| RBM39 | RNA binding motif protein 39 | -0.022928 |
| CUL4B | cullin 4B | -0.0229077 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0229052 |
| VEGFA | vascular endothelial growth factor A | -0.0226326 |
| USP3 | ubiquitin specific peptidase 3 | -0.0223165 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0222567 |
| RPS21 | ribosomal protein S21 | -0.0221877 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0218191 |
| MAP1B | microtubule-associated protein 1B | -0.0215389 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0215275 |
| NUP58 | nucleoporin 58 | -0.0214955 |
| VCL | vinculin | -0.0213594 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0213337 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0213257 |
| ADM | adrenomedullin | -0.0210893 |
| RPL28 | ribosomal protein L28 | -0.020838 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0207471 |
| SLC12A8 | solute carrier family 12, member 8 | -0.0206719 |
| SULF1 | sulfatase 1 | -0.020596 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0205537 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0204277 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0201302 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0201113 |
| DRAM1 | DNA-damage regulated autophagy modulator 1 | -0.0201091 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0200337 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0200128 |
| CADM1 | cell adhesion molecule 1 | -0.0199806 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0192941 |
| WTAP | Wilms tumor 1 associated protein | -0.0190512 |
| RPS6 | ribosomal protein S6 | -0.0187744 |
| DIAPH3 | diaphanous-related formin 3 | -0.0186473 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0185905 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0185678 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.018526 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0183975 |
| TLN1 | talin 1 | -0.0183699 |
| RPS10 | ribosomal protein S10 | -0.0183083 |
| RPS23 | ribosomal protein S23 | -0.0181988 |
| S100A9 | S100 calcium binding protein A9 | -0.0178351 |
