| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.181075 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.136822 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.131156 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.118387 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.109899 |
| LDHA | lactate dehydrogenase A | 0.107759 |
| TXNIP | thioredoxin interacting protein | 0.106744 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0932531 |
| GOLGA4 | golgin A4 | 0.0927845 |
| LMO7 | LIM domain 7 | 0.0910485 |
| FTL | ferritin, light polypeptide | 0.0863905 |
| EREG | epiregulin | 0.079807 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0767276 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0725409 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0696238 |
| KRT18 | keratin 18, type I | 0.069551 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0695505 |
| EPCAM | epithelial cell adhesion molecule | 0.0692547 |
| UBC | ubiquitin C | 0.0685394 |
| B2M | beta-2-microglobulin | 0.0677033 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0669492 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0650975 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0635841 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0588922 |
| FAT1 | FAT atypical cadherin 1 | 0.057558 |
| DSPP | dentin sialophosphoprotein | 0.0560911 |
| KIF5B | kinesin family member 5B | 0.0550285 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0540908 |
| RPS12 | ribosomal protein S12 | 0.0533767 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0527434 |
| WAC | WW domain containing adaptor with coiled-coil | 0.049216 |
| DSG2 | desmoglein 2 | 0.0489924 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0487737 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0482264 |
| CANX | calnexin | 0.0480453 |
| JMJD1C | jumonji domain containing 1C | 0.0475619 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0472753 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0469132 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0466878 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0456063 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0452753 |
| GDF15 | growth differentiation factor 15 | 0.0440204 |
| RACK1 | receptor for activated C kinase 1 | 0.043932 |
| TPI1 | triosephosphate isomerase 1 | 0.0425685 |
| AREG | amphiregulin | 0.0418809 |
| NEBL | nebulette | 0.0416462 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0412334 |
| ENO1 | enolase 1, (alpha) | 0.0404299 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0404285 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0401499 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0391016 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0390321 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0390266 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0384611 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0383685 |
| MUC13 | mucin 13, cell surface associated | 0.0383024 |
| MED13 | mediator complex subunit 13 | 0.0382985 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0381685 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0379032 |
| H1-0 | H1.0 linker histone | 0.0376457 |
| PDZD8 | PDZ domain containing 8 | 0.0372693 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0369547 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0366825 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0365203 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0358872 |
| RPLP0 | ribosomal protein, large, P0 | 0.0357753 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0355727 |
| SNX9 | sorting nexin 9 | 0.0354975 |
| YME1L1 | YME1-like 1 ATPase | 0.0354294 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0352964 |
| FAM13A | family with sequence similarity 13, member A | 0.0352461 |
| MUC17 | mucin 17, cell surface associated | 0.0349917 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0349496 |
| DSTN | destrin (actin depolymerizing factor) | 0.0348294 |
| RPS8 | ribosomal protein S8 | 0.0348001 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0343833 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0340018 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0339998 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0339125 |
| TMF1 | TATA element modulatory factor 1 | 0.0338759 |
| CALR | calreticulin | 0.0337689 |
| GOLGB1 | golgin B1 | 0.0333976 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0329674 |
| MED13L | mediator complex subunit 13-like | 0.0328246 |
| HDLBP | high density lipoprotein binding protein | 0.0325517 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.031984 |
| COG5 | component of oligomeric golgi complex 5 | 0.0319487 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0319288 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0317759 |
| ASTN2 | astrotactin 2 | 0.0314626 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0314283 |
| PIGR | polymeric immunoglobulin receptor | 0.03108 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0308587 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.030715 |
| RPS5 | ribosomal protein S5 | 0.030607 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0304443 |
| MYO5B | myosin VB | 0.0302935 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0302458 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0300872 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0300238 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.197018 |
| TMSB10 | thymosin beta 10 | -0.167851 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.104991 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0993889 |
| VCL | vinculin | -0.08227 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.080759 |
| TNS4 | tensin 4 | -0.0751121 |
| ONECUT3 | one cut homeobox 3 | -0.0724702 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.071577 |
| RPL35A | ribosomal protein L35a | -0.0685502 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0673973 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0572641 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0534235 |
| FLNB | filamin B, beta | -0.0533684 |
| MT2A | metallothionein 2A | -0.0532582 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0522718 |
| ACTN4 | actinin, alpha 4 | -0.0516945 |
| LAMA4 | laminin, alpha 4 | -0.045713 |
| S100P | S100 calcium binding protein P | -0.0430416 |
| RPS29 | ribosomal protein S29 | -0.0429258 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0421019 |
| CADPS | Ca++-dependent secretion activator | -0.0405577 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0397345 |
| PRELID2 | PRELI domain containing 2 | -0.0390229 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0386973 |
| POTEF | POTE ankyrin domain family, member F | -0.0375878 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0373283 |
| RPS21 | ribosomal protein S21 | -0.0371122 |
| PTMA | prothymosin, alpha | -0.0362005 |
| RPL36 | ribosomal protein L36 | -0.0359616 |
| DENND1A | DENN/MADD domain containing 1A | -0.0352103 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0342466 |
| RPLP1 | ribosomal protein, large, P1 | -0.0333999 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0331111 |
| EHBP1 | EH domain binding protein 1 | -0.0328413 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0327574 |
| EGR1 | early growth response 1 | -0.0323901 |
| RPS19 | ribosomal protein S19 | -0.032197 |
| AHNAK | AHNAK nucleoprotein | -0.0297783 |
| RNF43 | ring finger protein 43 | -0.0294913 |
| ITGB4 | integrin, beta 4 | -0.028959 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0285794 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0283367 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0281531 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0272924 |
| DIAPH3 | diaphanous-related formin 3 | -0.0271312 |
| RIN2 | Ras and Rab interactor 2 | -0.0269738 |
| PKP2 | plakophilin 2 | -0.0259402 |
| FHIT | fragile histidine triad | -0.0255092 |
| RPS11 | ribosomal protein S11 | -0.0247884 |
| RPLP2 | ribosomal protein, large, P2 | -0.0243588 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0243114 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0242441 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.02424 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0240891 |
| ATF4 | activating transcription factor 4 | -0.023645 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0235163 |
| RPL38 | ribosomal protein L38 | -0.0230715 |
| ABR | active BCR-related | -0.0230593 |
| RAB10 | RAB10, member RAS oncogene family | -0.0230486 |
| CENPF | centromere protein F, 350/400kDa | -0.0224092 |
| LSAMP | limbic system-associated membrane protein | -0.0223633 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0223553 |
| NRXN3 | neurexin 3 | -0.022241 |
| MT1E | metallothionein 1E | -0.0221482 |
| HMGB1 | high mobility group box 1 | -0.0217771 |
| EZR | ezrin | -0.021469 |
| VIM | vimentin | -0.0214575 |
| EPHA2 | EPH receptor A2 | -0.0214539 |
| ITGA6 | integrin, alpha 6 | -0.0214413 |
| ZNF518A | zinc finger protein 518A | -0.0213885 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0213289 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0211667 |
| TC2N | tandem C2 domains, nuclear | -0.0211357 |
| EGFR | epidermal growth factor receptor | -0.0210959 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0210327 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0210302 |
| GPR39 | G protein-coupled receptor 39 | -0.0208174 |
| RPL37A | ribosomal protein L37a | -0.0205409 |
| DIAPH2 | diaphanous-related formin 2 | -0.0203944 |
| RPL13A | ribosomal protein L13a | -0.0201228 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0201011 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.019824 |
| JUP | junction plakoglobin | -0.0194173 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0193388 |
| FERMT1 | fermitin family member 1 | -0.0192925 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0192192 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0191626 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0191273 |
| LUZP1 | leucine zipper protein 1 | -0.0190918 |
| HMGA2 | high mobility group AT-hook 2 | -0.0188864 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0185611 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0184686 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0183861 |
| EXOC4 | exocyst complex component 4 | -0.018371 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0183266 |
| SMYD3 | SET and MYND domain containing 3 | -0.0182134 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0180926 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0180488 |
| ATP11A | ATPase, class VI, type 11A | -0.0178976 |
