| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.135903 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.131069 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.127849 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.101705 |
| DSPP | dentin sialophosphoprotein | 0.0951784 |
| MYO1E | myosin IE | 0.0925432 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0858383 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0806212 |
| EZR | ezrin | 0.0789654 |
| RPS12 | ribosomal protein S12 | 0.0782139 |
| MYO5B | myosin VB | 0.0711462 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0662044 |
| LDHA | lactate dehydrogenase A | 0.061575 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0604009 |
| ANXA2 | annexin A2 | 0.0603794 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0595794 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0563311 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0559154 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0551254 |
| CTBP2 | C-terminal binding protein 2 | 0.0532069 |
| INTS6 | integrator complex subunit 6 | 0.0515458 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0505815 |
| TJP1 | tight junction protein 1 | 0.0499342 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0482088 |
| OXSR1 | oxidative stress responsive 1 | 0.0465587 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0445186 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0439124 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0436609 |
| UBC | ubiquitin C | 0.0422088 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0416996 |
| RPL3 | ribosomal protein L3 | 0.0414827 |
| BRD2 | bromodomain containing 2 | 0.0410214 |
| PKM | pyruvate kinase, muscle | 0.0407222 |
| ASPH | aspartate beta-hydroxylase | 0.0395731 |
| FRMD5 | FERM domain containing 5 | 0.0394188 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0386097 |
| LRRC23 | leucine rich repeat containing 23 | 0.0384974 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0384909 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0373384 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0369208 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0364409 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0359486 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0358989 |
| SLTM | SAFB-like, transcription modulator | 0.0355021 |
| KRT18 | keratin 18, type I | 0.0353352 |
| NDRG1 | N-myc downstream regulated 1 | 0.0352211 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0349452 |
| SQSTM1 | sequestosome 1 | 0.0342967 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0334223 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0333457 |
| FAT1 | FAT atypical cadherin 1 | 0.0331931 |
| PDZD8 | PDZ domain containing 8 | 0.0323497 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0322084 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0317167 |
| RPS17 | ribosomal protein S17 | 0.0316403 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0315046 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0308712 |
| MCL1 | myeloid cell leukemia 1 | 0.0306176 |
| TXNIP | thioredoxin interacting protein | 0.0305019 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0304643 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0304583 |
| KRT8 | keratin 8, type II | 0.0302215 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0296509 |
| MUC13 | mucin 13, cell surface associated | 0.0291513 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0291023 |
| RPL7 | ribosomal protein L7 | 0.0289598 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0283617 |
| LOC105378220 | macrophage receptor MARCO-like | 0.0281779 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0278779 |
| CLIC5 | chloride intracellular channel 5 | 0.0276469 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0276316 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0275433 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0275102 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0269967 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.026588 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0265867 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0265523 |
| SLC6A20 | solute carrier family 6 (proline IMINO transporter), member 20 | 0.0264418 |
| ARRDC3 | arrestin domain containing 3 | 0.0262897 |
| EMP1 | epithelial membrane protein 1 | 0.0257161 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0255093 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0253927 |
| DSG2 | desmoglein 2 | 0.0252935 |
| VMP1 | vacuole membrane protein 1 | 0.0249774 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0245937 |
| PGK1 | phosphoglycerate kinase 1 | 0.0245174 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0244849 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.024464 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0244128 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.024343 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0242824 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0241239 |
| EFNB2 | ephrin-B2 | 0.0239462 |
| GOLGB1 | golgin B1 | 0.0238715 |
| RREB1 | ras responsive element binding protein 1 | 0.0237587 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0233638 |
| SGMS2 | sphingomyelin synthase 2 | 0.0232892 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0232885 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0232861 |
| DST | dystonin | 0.0228191 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.168486 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.141516 |
| TMSB10 | thymosin beta 10 | -0.0967785 |
| PTMA | prothymosin, alpha | -0.0931365 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0816347 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.077213 |
| RPLP1 | ribosomal protein, large, P1 | -0.071698 |
| RPLP0 | ribosomal protein, large, P0 | -0.0694753 |
| PLAC8 | placenta-specific 8 | -0.0667594 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0649498 |
| RPL35A | ribosomal protein L35a | -0.0567323 |
| VCL | vinculin | -0.052128 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0516697 |
| GDF15 | growth differentiation factor 15 | -0.0441572 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0407503 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0400033 |
| RBM25 | RNA binding motif protein 25 | -0.0400024 |
| GOLGA4 | golgin A4 | -0.0399735 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0396569 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0393041 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0388688 |
| TXNRD1 | thioredoxin reductase 1 | -0.0387121 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0377976 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.037522 |
| MKI67 | marker of proliferation Ki-67 | -0.0365866 |
| PCDHB16 | protocadherin beta 16 | -0.036035 |
| CALB1 | calbindin 1, 28kDa | -0.0356796 |
| PKP2 | plakophilin 2 | -0.035583 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0339081 |
| YBX3 | Y box binding protein 3 | -0.0328879 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0328027 |
| TRIM2 | tripartite motif containing 2 | -0.0327167 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0321865 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0321337 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0320649 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0314987 |
| CENPF | centromere protein F, 350/400kDa | -0.0312578 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0305725 |
| TCF12 | transcription factor 12 | -0.0304301 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0300546 |
| THOC2 | THO complex 2 | -0.0293807 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0291105 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0290051 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0283911 |
| POU2F1 | POU class 2 homeobox 1 | -0.0283305 |
| RPL13A | ribosomal protein L13a | -0.0283089 |
| DIAPH3 | diaphanous-related formin 3 | -0.0281182 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.0279598 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0277522 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0273855 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0268454 |
| RPL5 | ribosomal protein L5 | -0.0266163 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0263372 |
| EREG | epiregulin | -0.0263297 |
| PTEN | phosphatase and tensin homolog | -0.026313 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0262101 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.02562 |
| RPS3 | ribosomal protein S3 | -0.0252415 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.025208 |
| HMGB2 | high mobility group box 2 | -0.0250572 |
| DEK | DEK proto-oncogene | -0.0250035 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0249397 |
| CCPG1 | cell cycle progression 1 | -0.0247358 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0244862 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0243111 |
| FERMT1 | fermitin family member 1 | -0.0241138 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.023741 |
| RPL12 | ribosomal protein L12 | -0.0236055 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0235974 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0234804 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0234588 |
| LIN54 | lin-54 DREAM MuvB core complex component | -0.0233183 |
| NF1 | neurofibromin 1 | -0.0231273 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0229885 |
| MYO1D | myosin ID | -0.022926 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.0229152 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0228308 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0227573 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | -0.0225894 |
| EGR1 | early growth response 1 | -0.0225077 |
| RAD51B | RAD51 paralog B | -0.0224297 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0222993 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0222861 |
| ANLN | anillin, actin binding protein | -0.0222101 |
| NCOR1 | nuclear receptor corepressor 1 | -0.022004 |
| NFIA | nuclear factor I/A | -0.021968 |
| RPL34 | ribosomal protein L34 | -0.0219632 |
| CDK19 | cyclin-dependent kinase 19 | -0.0219114 |
| ATF4 | activating transcription factor 4 | -0.0217749 |
| RIGI | RNA sensor RIG-I | -0.0215267 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0215172 |
| CARS1 | cysteinyl-tRNA synthetase 1 | -0.0214281 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0214174 |
| FOXO1 | forkhead box O1 | -0.0214026 |
| MATR3 | matrin 3 | -0.0213358 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0213155 |
| RNF145 | ring finger protein 145 | -0.021243 |
| PRSS3 | protease, serine, 3 | -0.0212063 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0211965 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0211925 |
