LY-2584702 (tosylate salt)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY-2584702 (tosylate salt) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY-2584702 (tosylate salt)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.355365
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.103495
MT2A metallothionein 2A 0.094041
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0569173
MCL1 myeloid cell leukemia 1 0.0490627
FTH1 ferritin, heavy polypeptide 1 0.0484004
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0461405
FTL ferritin, light polypeptide 0.0438883
STC1 stanniocalcin 1 0.0438145
SEC61G Sec61 gamma subunit 0.0431504
ELL2 elongation factor, RNA polymerase II, 2 0.0425341
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0423889
AGO2 argonaute RISC catalytic component 2 0.0414365
RPLP1 ribosomal protein, large, P1 0.0412544
UBC ubiquitin C 0.0391511
FAM13A family with sequence similarity 13, member A 0.0329907
ARRDC3 arrestin domain containing 3 0.0327251
SOD2 superoxide dismutase 2, mitochondrial 0.0325358
JMJD1C jumonji domain containing 1C 0.0316484
LOC112694756 uncharaterized LOC112694756 0.0313341
ANKRD12 ankyrin repeat domain 12 0.0308573
NAMPT nicotinamide phosphoribosyltransferase 0.0305265
RUNX1 runt-related transcription factor 1 0.0293301
SLTM SAFB-like, transcription modulator 0.028932
BLZF1 basic leucine zipper nuclear factor 1 0.0284296
MT1X metallothionein 1X 0.027128
SPAG9 sperm associated antigen 9 0.0270002
CEMIP cell migration inducing protein, hyaluronan binding 0.0266399
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0259412
KMT2E lysine (K)-specific methyltransferase 2E 0.0257391
ANKRD37 ankyrin repeat domain 37 0.0246984
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0245941
DTNA dystrobrevin, alpha 0.0242861
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0238429
CXCL8 chemokine (C-X-C motif) ligand 8 0.0234562
CCNL1 cyclin L1 0.0233948
EIF1 eukaryotic translation initiation factor 1 0.0226301
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0225731
RPLP0 ribosomal protein, large, P0 0.0213125
CSNK1E casein kinase 1, epsilon 0.0210792
ZNF292 zinc finger protein 292 0.0208658
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0207684
RAB7A RAB7A, member RAS oncogene family 0.0206344
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0201813
BTG1 B-cell translocation gene 1, anti-proliferative 0.0196141
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.019339
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0192806
USP34 ubiquitin specific peptidase 34 0.0191779
CSNK1A1 casein kinase 1, alpha 1 0.0190058
PYGL phosphorylase, glycogen, liver 0.0186092
UBA6 ubiquitin-like modifier activating enzyme 6 0.0182997
PCBP2 poly(rC) binding protein 2 0.0174109
DDIT4 DNA-damage-inducible transcript 4 0.0173993
BRD2 bromodomain containing 2 0.0172723
EIF4A2 eukaryotic translation initiation factor 4A2 0.0167652
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0164695
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0164547
YBX3 Y box binding protein 3 0.0164193
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0163943
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0163077
SIK3 SIK family kinase 3 0.0159925
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.015934
MCTP1 multiple C2 domains, transmembrane 1 0.0158762
ADAM9 ADAM metallopeptidase domain 9 0.0156136
IGFBP3 insulin-like growth factor binding protein 3 0.0153671
MYH9 myosin, heavy chain 9, non-muscle 0.015175
DSCAM Down syndrome cell adhesion molecule 0.0150699
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0150625
GPHN gephyrin 0.0150399
KDM2A lysine (K)-specific demethylase 2A 0.015035
ZNF638 zinc finger protein 638 0.0150045
ERRFI1 ERBB receptor feedback inhibitor 1 0.0148581
CIB1 calcium and integrin binding 1 (calmyrin) 0.0148334
HSPA8 heat shock 70kDa protein 8 0.0147941
CUL4A cullin 4A 0.0147872
CES1 carboxylesterase 1 0.0147512
RPL7 ribosomal protein L7 0.0144378
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0143408
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0143347
RTN4 reticulon 4 0.0142282
RNMT RNA (guanine-7-) methyltransferase 0.0140376
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0139955
KTN1 kinectin 1 (kinesin receptor) 0.0139414
PRRC2C proline-rich coiled-coil 2C 0.0139124
CHMP1B charged multivesicular body protein 1B 0.0135487
HILPDA hypoxia inducible lipid droplet-associated 0.0134474
CCL20 chemokine (C-C motif) ligand 20 0.0134253
PNRC1 proline-rich nuclear receptor coactivator 1 0.0134222
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0130702
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0129006
RPL30 ribosomal protein L30 0.0126751
MAP2K1 mitogen-activated protein kinase kinase 1 0.0126409
MKI67 marker of proliferation Ki-67 0.0125713
TSC22D2 TSC22 domain family, member 2 0.0124779
SON SON DNA binding protein 0.0124317
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0122478
GLS2 glutaminase 2 (liver, mitochondrial) 0.0120656
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0118003
ENO1 enolase 1, (alpha) 0.0117952
FAM193A family with sequence similarity 193, member A 0.0116972

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.115919
TMSB10 thymosin beta 10 -0.102993
ASPH aspartate beta-hydroxylase -0.100839
PTPRM protein tyrosine phosphatase, receptor type, M -0.0775214
TPT1 tumor protein, translationally-controlled 1 -0.0639511
CAV1 caveolin 1, caveolae protein, 22kDa -0.0583868
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0552972
THSD4 thrombospondin, type I, domain containing 4 -0.0510114
ACTG1 actin gamma 1 -0.0506783
RPS25 ribosomal protein S25 -0.0474731
LMO7 LIM domain 7 -0.0418518
LAMC2 laminin, gamma 2 -0.0416546
KRT7 keratin 7, type II -0.0401072
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0398617
RPL37A ribosomal protein L37a -0.0391231
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0371355
PDE4D phosphodiesterase 4D, cAMP-specific -0.0331782
RPS12 ribosomal protein S12 -0.0321898
SCEL sciellin -0.0307959
RPS29 ribosomal protein S29 -0.0290835
RAB27B RAB27B, member RAS oncogene family -0.0281071
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0275754
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0271953
HLA-B major histocompatibility complex, class I, B -0.0270197
AKR1C1 aldo-keto reductase family 1, member C1 -0.0269019
ANXA2 annexin A2 -0.0268217
FLNB filamin B, beta -0.0265324
LRP1B low density lipoprotein receptor-related protein 1B -0.0256697
RPL31 ribosomal protein L31 -0.0242456
TXNRD1 thioredoxin reductase 1 -0.0234639
LGALS12 lectin, galactoside-binding, soluble, 12 -0.022325
EFNA5 ephrin-A5 -0.022123
AHNAK AHNAK nucleoprotein -0.0217159
KRT18 keratin 18, type I -0.0216378
CCND1 cyclin D1 -0.0210135
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0208477
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0207926
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0205422
RPS27A ribosomal protein S27a -0.0205058
OSMR oncostatin M receptor -0.020235
EGR1 early growth response 1 -0.0202072
SDC1 syndecan 1 -0.0201755
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0201182
KRT8 keratin 8, type II -0.0199664
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0199562
PRKCA protein kinase C, alpha -0.019918
RPS24 ribosomal protein S24 -0.0192337
IFI6 interferon, alpha-inducible protein 6 -0.019098
S100P S100 calcium binding protein P -0.018604
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0183459
POTEF POTE ankyrin domain family, member F -0.0182014
HDLBP high density lipoprotein binding protein -0.0178844
RPL36A ribosomal protein L36a -0.0178842
PKM pyruvate kinase, muscle -0.0176973
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0176295
IGFBP5 insulin-like growth factor binding protein 5 -0.0174503
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0174033
ANKRD10 ankyrin repeat domain 10 -0.0170563
MGST1 microsomal glutathione S-transferase 1 -0.0166085
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0166031
AGR2 anterior gradient 2 -0.0165744
EHBP1 EH domain binding protein 1 -0.0164378
RPS23 ribosomal protein S23 -0.0163915
SLC38A2 solute carrier family 38, member 2 -0.0162224
CUX1 cut-like homeobox 1 -0.0160877
NCOA3 nuclear receptor coactivator 3 -0.0160843
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0160146
PDLIM5 PDZ and LIM domain 5 -0.0159291
GCLC glutamate-cysteine ligase, catalytic subunit -0.0157445
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0154835
RPS11 ribosomal protein S11 -0.0154001
PATJ PATJ crumbs cell polarity complex component -0.0153875
HMGA1 high mobility group AT-hook 1 -0.0153286
ARHGAP32 Rho GTPase activating protein 32 -0.0153198
S100A10 S100 calcium binding protein A10 -0.0151618
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0151089
PCED1B PC-esterase domain containing 1B -0.0151056
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0150437
AKAP12 A kinase (PRKA) anchor protein 12 -0.0150341
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0149507
TNS3 tensin 3 -0.0149449
MCU mitochondrial calcium uniporter -0.0149346
DSPP dentin sialophosphoprotein -0.0147626
MAML3 mastermind-like 3 (Drosophila) -0.0147267
VCL vinculin -0.0146021
TAS2R14 taste receptor, type 2, member 14 -0.0145825
KRT19 keratin 19, type I -0.0145383
LAMA4 laminin, alpha 4 -0.0144077
RPLP2 ribosomal protein, large, P2 -0.0142886
UGDH UDP-glucose 6-dehydrogenase -0.0142601
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0142051
AHNAK2 AHNAK nucleoprotein 2 -0.0137385
PERP PERP, TP53 apoptosis effector -0.0136902
RIMS2 regulating synaptic membrane exocytosis 2 -0.013494
RABGAP1L RAB GTPase activating protein 1-like -0.0134684
RCOR1 REST corepressor 1 -0.0134436
TES testin LIM domain protein -0.0132896
SPIRE1 spire-type actin nucleation factor 1 -0.0131582
SDC4 syndecan 4 -0.0130059
RPL26 ribosomal protein L26 -0.0129895