LY-2584702 (tosylate salt)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY-2584702 (tosylate salt) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY-2584702 (tosylate salt)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0945143
SDK1 sidekick cell adhesion molecule 1 0.0940689
FN1 fibronectin 1 0.0935453
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0902779
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0851073
EFNA5 ephrin-A5 0.0755537
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0742979
IGFBP3 insulin-like growth factor binding protein 3 0.0706854
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0687341
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0644153
LOX lysyl oxidase 0.0641801
HMGA2 high mobility group AT-hook 2 0.0634537
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0633733
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0601675
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0593893
NAV2 neuron navigator 2 0.0590573
SOD2 superoxide dismutase 2, mitochondrial 0.0557067
CDCP1 CUB domain containing protein 1 0.0536528
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0535537
TGM2 transglutaminase 2 0.0512865
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0507235
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0497298
NDRG1 N-myc downstream regulated 1 0.0490927
CA12 carbonic anhydrase XII 0.0489561
ANGPTL4 angiopoietin-like 4 0.0483141
EGFR epidermal growth factor receptor 0.0470356
PDE4D phosphodiesterase 4D, cAMP-specific 0.0461053
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0455645
DST dystonin 0.0438959
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0421433
FAM20C family with sequence similarity 20, member C 0.0416181
MTSS1 metastasis suppressor 1 0.0415928
CDH13 cadherin 13 0.0415017
TIMP1 TIMP metallopeptidase inhibitor 1 0.0407911
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.040361
PSD3 pleckstrin and Sec7 domain containing 3 0.0398154
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0387748
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0373906
IFI44L interferon-induced protein 44-like 0.0362944
GRB10 growth factor receptor-bound protein 10 0.0362592
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0357577
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0357294
MSRB3 methionine sulfoxide reductase B3 0.0355159
ANTXR2 anthrax toxin receptor 2 0.0351448
CD44 CD44 molecule (Indian blood group) 0.0346501
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0346154
APLP2 amyloid beta (A4) precursor-like protein 2 0.0341514
MAML3 mastermind-like 3 (Drosophila) 0.0341112
FNDC3B fibronectin type III domain containing 3B 0.0339552
PCBP2 poly(rC) binding protein 2 0.0338512
DOCK5 dedicator of cytokinesis 5 0.0318453
SEPTIN9 septin 9 0.0317021
RAD51B RAD51 paralog B 0.0311832
PKM pyruvate kinase, muscle 0.031155
ASPH aspartate beta-hydroxylase 0.0307166
NRP1 neuropilin 1 0.030553
B2M beta-2-microglobulin 0.0299542
NAV1 neuron navigator 1 0.0286689
MT2A metallothionein 2A 0.02866
SMAD3 SMAD family member 3 0.028659
PLIN2 perilipin 2 0.0284837
ATXN1 ataxin 1 0.0284795
IFI6 interferon, alpha-inducible protein 6 0.028277
VEGFA vascular endothelial growth factor A 0.0281934
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0280723
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0277842
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0275679
MACF1 microtubule-actin crosslinking factor 1 0.0271192
LDHA lactate dehydrogenase A 0.0269727
ITGAV integrin, alpha V 0.0262524
STC1 stanniocalcin 1 0.0257537
MYO10 myosin X 0.0256492
PYGL phosphorylase, glycogen, liver 0.0255427
SAMD9 sterile alpha motif domain containing 9 0.025163
SRRM2 serine/arginine repetitive matrix 2 0.0250962
NPAS2 neuronal PAS domain protein 2 0.0248534
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0246895
MX1 MX dynamin-like GTPase 1 0.0244239
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0240802
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.024028
HMGA1 high mobility group AT-hook 1 0.0237838
NRG1 neuregulin 1 0.0236195
USP34 ubiquitin specific peptidase 34 0.0232815
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0231906
AADAC arylacetamide deacetylase 0.0228547
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0227998
FER fer (fps/fes related) tyrosine kinase 0.0217182
MSN moesin 0.021549
PTK2 protein tyrosine kinase 2 0.0215081
ECE1 endothelin converting enzyme 1 0.0214929
LOXL2 lysyl oxidase-like 2 0.0214792
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0213065
MAML2 mastermind-like 2 (Drosophila) 0.0205577
DTNA dystrobrevin, alpha 0.0203678
ENO1 enolase 1, (alpha) 0.0201255
TIMP2 TIMP metallopeptidase inhibitor 2 0.0197025
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0196812
MCL1 myeloid cell leukemia 1 0.0196531
MEF2A myocyte enhancer factor 2A 0.0194359
IL6ST interleukin 6 signal transducer 0.0193201

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.243846
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.218311
NAMPT nicotinamide phosphoribosyltransferase -0.148855
RBM39 RNA binding motif protein 39 -0.0923385
TMSB10 thymosin beta 10 -0.0867057
KDM3A lysine (K)-specific demethylase 3A -0.0854227
GOLGA4 golgin A4 -0.0817538
PTMA prothymosin, alpha -0.0754994
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0595175
FTL ferritin, light polypeptide -0.058463
RAB1A RAB1A, member RAS oncogene family -0.0568103
IER3 immediate early response 3 -0.0560663
RPLP1 ribosomal protein, large, P1 -0.0543747
USP3 ubiquitin specific peptidase 3 -0.0533908
OGA O-GlcNAcase -0.0524015
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0487521
BASP1 brain abundant, membrane attached signal protein 1 -0.0461103
LMAN1 lectin, mannose-binding, 1 -0.0437046
C15ORF48 chromosome 15 open reading frame 48 -0.0412181
GNAS GNAS complex locus -0.0407782
HDLBP high density lipoprotein binding protein -0.0396743
CANX calnexin -0.0394615
WDR45B WD repeat domain 45B -0.0387961
CALR calreticulin -0.0386281
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0384375
TMEM263 transmembrane protein 263 -0.0373497
MARCHF6 membrane associated ring-CH-type finger 6 -0.0373157
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0371602
WAC WW domain containing adaptor with coiled-coil -0.0368719
NPEPPS aminopeptidase puromycin sensitive -0.036068
KDM2A lysine (K)-specific demethylase 2A -0.035685
NCOA7 nuclear receptor coactivator 7 -0.0345235
SPAG9 sperm associated antigen 9 -0.0344846
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0343154
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0341396
GARS1 glycyl-tRNA synthetase 1 -0.0335129
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0334326
RPS21 ribosomal protein S21 -0.0326496
SRP54 signal recognition particle 54kDa -0.032433
SLC38A1 solute carrier family 38, member 1 -0.032047
COPA coatomer protein complex, subunit alpha -0.0319719
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.031864
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0309741
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0303467
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0300411
NIPBL Nipped-B homolog (Drosophila) -0.0299711
KMT2C lysine (K)-specific methyltransferase 2C -0.029921
PDIA4 protein disulfide isomerase family A, member 4 -0.0295
RPL35A ribosomal protein L35a -0.0292441
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0292225
ELL2 elongation factor, RNA polymerase II, 2 -0.0292186
LCORL ligand dependent nuclear receptor corepressor-like -0.0290096
TPT1 tumor protein, translationally-controlled 1 -0.0284707
PRRC2C proline-rich coiled-coil 2C -0.0277278
PUM2 pumilio RNA-binding family member 2 -0.0275163
RLF rearranged L-myc fusion -0.0269526
TRIO trio Rho guanine nucleotide exchange factor -0.0267493
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0264645
DLG1 discs, large homolog 1 (Drosophila) -0.0261563
BZW1 basic leucine zipper and W2 domains 1 -0.0260998
STRN3 striatin, calmodulin binding protein 3 -0.0260652
MORF4L2 mortality factor 4 like 2 -0.0257324
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.025573
TRA2A transformer 2 alpha homolog (Drosophila) -0.0253973
RPS24 ribosomal protein S24 -0.0252165
VDAC1 voltage-dependent anion channel 1 -0.0251084
RNF145 ring finger protein 145 -0.0250162
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0244382
KPNB1 karyopherin (importin) beta 1 -0.0243549
RAD21 RAD21 homolog (S. pombe) -0.0238795
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.023687
COL12A1 collagen, type XII, alpha 1 -0.0234528
MARS1 methionyl-tRNA synthetase 1 -0.0233677
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0233138
OXSR1 oxidative stress responsive 1 -0.0231877
USP15 ubiquitin specific peptidase 15 -0.02306
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0229503
EIF1 eukaryotic translation initiation factor 1 -0.0229127
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0228331
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0227659
GSTP1 glutathione S-transferase pi 1 -0.022731
COPB1 coatomer protein complex, subunit beta 1 -0.0223693
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0222709
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0220953
YME1L1 YME1-like 1 ATPase -0.0220877
YBX1 Y box binding protein 1 -0.022064
YBX3 Y box binding protein 3 -0.0219195
RPL12 ribosomal protein L12 -0.0218996
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0217095
SEPTIN7 septin 7 -0.0215789
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0215314
RPL34 ribosomal protein L34 -0.0213598
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0213315
MON2 MON2 homolog (S. cerevisiae) -0.0212661
ANKRD11 ankyrin repeat domain 11 -0.0211544
NOP58 NOP58 ribonucleoprotein -0.0210331
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.020543
TARS1 threonyl-tRNA synthetase 1 -0.020543
COG5 component of oligomeric golgi complex 5 -0.0205188
CDC73 cell division cycle 73 -0.0205136