| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.116515 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0672362 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0562232 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0399253 |
| FTL | ferritin, light polypeptide | 0.031425 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0291312 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0277737 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0265504 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0262156 |
| TPM3 | tropomyosin 3 | 0.0251839 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0250437 |
| TPD52 | tumor protein D52 | 0.0248607 |
| PCBP2 | poly(rC) binding protein 2 | 0.024722 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0236886 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0232601 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0223676 |
| NOP58 | NOP58 ribonucleoprotein | 0.0223401 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0219098 |
| ZNF292 | zinc finger protein 292 | 0.0218006 |
| RPL7 | ribosomal protein L7 | 0.0216837 |
| FGB | fibrinogen beta chain | 0.0212987 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0212797 |
| RBM39 | RNA binding motif protein 39 | 0.0212238 |
| UBC | ubiquitin C | 0.0210082 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0209403 |
| WDR43 | WD repeat domain 43 | 0.020746 |
| TPI1 | triosephosphate isomerase 1 | 0.0206271 |
| RNF145 | ring finger protein 145 | 0.0197379 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.019681 |
| CCNL1 | cyclin L1 | 0.0194904 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0194417 |
| KIF5B | kinesin family member 5B | 0.0188487 |
| RPS12 | ribosomal protein S12 | 0.018833 |
| TXNRD1 | thioredoxin reductase 1 | 0.0187416 |
| PFN1 | profilin 1 | 0.0186926 |
| RPL19 | ribosomal protein L19 | 0.018596 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0185919 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0185119 |
| NUP58 | nucleoporin 58 | 0.0183266 |
| MSN | moesin | 0.0181088 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0178271 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0174562 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0174016 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.016825 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0166863 |
| RBM25 | RNA binding motif protein 25 | 0.0165632 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0161503 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0161364 |
| RPL18 | ribosomal protein L18 | 0.0159612 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0157292 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0156426 |
| NCKAP1 | NCK-associated protein 1 | 0.0154699 |
| YY1 | YY1 transcription factor | 0.0154099 |
| USP3 | ubiquitin specific peptidase 3 | 0.0153924 |
| SFPQ | splicing factor proline/glutamine-rich | 0.015337 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0151019 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0150974 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0150912 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0148604 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0146186 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0145781 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0144952 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | 0.0144918 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0141975 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0141462 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0141127 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0140926 |
| MYOF | myoferlin | 0.0139657 |
| RPL3 | ribosomal protein L3 | 0.013795 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0137358 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0137265 |
| ZNF207 | zinc finger protein 207 | 0.013712 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.013695 |
| TFG | TRK-fused gene | 0.0136568 |
| CDC73 | cell division cycle 73 | 0.0136274 |
| BRD2 | bromodomain containing 2 | 0.0136071 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0135629 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.013486 |
| SON | SON DNA binding protein | 0.0133002 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0132117 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0131346 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0130701 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0130562 |
| CUL3 | cullin 3 | 0.0130554 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0130076 |
| CLU | clusterin | 0.013005 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0129578 |
| YME1L1 | YME1-like 1 ATPase | 0.0128149 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0127819 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0126295 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0126085 |
| ASTN2 | astrotactin 2 | 0.012567 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0123851 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0123644 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0121016 |
| RPS19 | ribosomal protein S19 | 0.0120962 |
| LDHB | lactate dehydrogenase B | 0.0120955 |
| YTHDC1 | YTH domain containing 1 | 0.0120642 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0120523 |
| RLF | rearranged L-myc fusion | 0.012038 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0763229 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0736976 |
| PTMA | prothymosin, alpha | -0.0672262 |
| ACTG1 | actin gamma 1 | -0.0558241 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0536526 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0497486 |
| IGF2 | insulin-like growth factor 2 | -0.0496533 |
| TMSB10 | thymosin beta 10 | -0.049204 |
| VIM | vimentin | -0.0414522 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0414037 |
| IER3 | immediate early response 3 | -0.040973 |
| RPL35A | ribosomal protein L35a | -0.0395099 |
| CMIP | c-Maf inducing protein | -0.0388392 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0342183 |
| BICC1 | BicC family RNA binding protein 1 | -0.0337296 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0329534 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0328198 |
| EGR1 | early growth response 1 | -0.0319911 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0272192 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0270709 |
| GLIS3 | GLIS family zinc finger 3 | -0.0264906 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0260231 |
| CAVIN1 | caveolae associated protein 1 | -0.0253731 |
| EGFR | epidermal growth factor receptor | -0.024763 |
| SVIL | supervillin | -0.0247453 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0242153 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0237318 |
| VCL | vinculin | -0.023508 |
| OSMR | oncostatin M receptor | -0.0232595 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0231894 |
| EHBP1 | EH domain binding protein 1 | -0.0226758 |
| HDAC9 | histone deacetylase 9 | -0.0225543 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0222001 |
| EFNA5 | ephrin-A5 | -0.0221397 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.021556 |
| RPLP1 | ribosomal protein, large, P1 | -0.0215309 |
| S100A6 | S100 calcium binding protein A6 | -0.0209287 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0208331 |
| GRAMD1B | GRAM domain containing 1B | -0.0207488 |
| RPS24 | ribosomal protein S24 | -0.0207259 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0204277 |
| AHNAK | AHNAK nucleoprotein | -0.0202702 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.020223 |
| HMGA2 | high mobility group AT-hook 2 | -0.0201681 |
| NEGR1 | neuronal growth regulator 1 | -0.0200635 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.019863 |
| PCNX4 | pecanex 4 | -0.0198033 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0197413 |
| CUX1 | cut-like homeobox 1 | -0.0197338 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.019666 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0195697 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0191485 |
| CDK12 | cyclin-dependent kinase 12 | -0.0188985 |
| PYGL | phosphorylase, glycogen, liver | -0.0184917 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0181253 |
| RPL34 | ribosomal protein L34 | -0.0177157 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0176853 |
| RAD51B | RAD51 paralog B | -0.0175287 |
| USP34 | ubiquitin specific peptidase 34 | -0.0172867 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0169625 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0168718 |
| ANGPTL4 | angiopoietin-like 4 | -0.0167385 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0160632 |
| NF1 | neurofibromin 1 | -0.0158581 |
| POTEF | POTE ankyrin domain family, member F | -0.0158442 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0157088 |
| NEBL | nebulette | -0.0157013 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0156345 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0155852 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0155767 |
| INTS6 | integrator complex subunit 6 | -0.0153457 |
| ATG7 | autophagy related 7 | -0.0151647 |
| AK1 | adenylate kinase 1 | -0.0151237 |
| FBXO11 | F-box protein 11 | -0.0150795 |
| HLA-E | major histocompatibility complex, class I, E | -0.014888 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0148849 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0148136 |
| TPM1 | tropomyosin 1 (alpha) | -0.0145496 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0145027 |
| RPL38 | ribosomal protein L38 | -0.014371 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0143472 |
| TPM4 | tropomyosin 4 | -0.0142722 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0141728 |
| DST | dystonin | -0.013998 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0138504 |
| FOXP1 | forkhead box P1 | -0.0137853 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0136732 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0136705 |
| PCED1B | PC-esterase domain containing 1B | -0.0134951 |
| KYNU | kynureninase | -0.0134601 |
| FDPS | farnesyl diphosphate synthase | -0.0132988 |
| NAV3 | neuron navigator 3 | -0.0129706 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.012939 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0128169 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0127921 |
| RPS21 | ribosomal protein S21 | -0.0127178 |
| KPNB1 | karyopherin (importin) beta 1 | -0.012532 |
| NLK | nemo-like kinase | -0.0124098 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0122658 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0122499 |
