| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.177226 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.144629 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.127943 |
| MT2A | metallothionein 2A | 0.11702 |
| NDRG1 | N-myc downstream regulated 1 | 0.107499 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0926796 |
| PDE10A | phosphodiesterase 10A | 0.0916502 |
| KYNU | kynureninase | 0.0817188 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0775773 |
| KRT17 | keratin 17, type I | 0.0756209 |
| CLEC2D | C-type lectin domain family 2, member D | 0.0749918 |
| LAMB3 | laminin, beta 3 | 0.0701399 |
| RPL37A | ribosomal protein L37a | 0.0669257 |
| RPL32 | ribosomal protein L32 | 0.0655792 |
| RBM39 | RNA binding motif protein 39 | 0.0618453 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.060689 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0605145 |
| JMJD1C | jumonji domain containing 1C | 0.0570429 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0533455 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0530253 |
| DUSP16 | dual specificity phosphatase 16 | 0.0525418 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0516288 |
| LDHA | lactate dehydrogenase A | 0.0510762 |
| MYO1E | myosin IE | 0.0508753 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0500859 |
| RPS16 | ribosomal protein S16 | 0.049699 |
| MYOF | myoferlin | 0.0493876 |
| RPL23 | ribosomal protein L23 | 0.0492118 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0484679 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0481456 |
| RPL31 | ribosomal protein L31 | 0.0479987 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0479446 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0475308 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0467506 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0467094 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.044646 |
| RPL37 | ribosomal protein L37 | 0.0427343 |
| GOLGA4 | golgin A4 | 0.0425619 |
| RTN4 | reticulon 4 | 0.0421357 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0420904 |
| SPAG9 | sperm associated antigen 9 | 0.0415505 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0410069 |
| RACK1 | receptor for activated C kinase 1 | 0.0409114 |
| RPL28 | ribosomal protein L28 | 0.0402706 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.038835 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.03795 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0378519 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0375345 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0373948 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0368204 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0361314 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0358267 |
| RPL18 | ribosomal protein L18 | 0.0356554 |
| BRD2 | bromodomain containing 2 | 0.0354109 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0351761 |
| RPL7 | ribosomal protein L7 | 0.0347719 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0341928 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0341276 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0338877 |
| RPS12 | ribosomal protein S12 | 0.0338644 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0335815 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0334143 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0325199 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.032487 |
| CLINT1 | clathrin interactor 1 | 0.0321859 |
| CMIP | c-Maf inducing protein | 0.0318378 |
| RPS23 | ribosomal protein S23 | 0.0318116 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0314117 |
| RPL15 | ribosomal protein L15 | 0.0313881 |
| TJP1 | tight junction protein 1 | 0.0312393 |
| RPLP2 | ribosomal protein, large, P2 | 0.0308931 |
| MYO10 | myosin X | 0.0307997 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0306664 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0303219 |
| RPL13A | ribosomal protein L13a | 0.030313 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0301924 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0294877 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0290292 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0290281 |
| TKT | transketolase | 0.0285579 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0285182 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0284833 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0264789 |
| RPL36A | ribosomal protein L36a | 0.0257394 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0252268 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.025186 |
| ANXA2 | annexin A2 | 0.0251448 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0251314 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.0250549 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0245395 |
| USP34 | ubiquitin specific peptidase 34 | 0.0242055 |
| RPS14 | ribosomal protein S14 | 0.0241127 |
| RPS29 | ribosomal protein S29 | 0.0237287 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0236937 |
| RPS17 | ribosomal protein S17 | 0.0233696 |
| SETD2 | SET domain containing 2 | 0.0233672 |
| ENO1 | enolase 1, (alpha) | 0.0229995 |
| CEP350 | centrosomal protein 350kDa | 0.0227519 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0227133 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0226856 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.136055 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.117981 |
| HLA-B | major histocompatibility complex, class I, B | -0.116402 |
| VIM | vimentin | -0.102354 |
| MSI2 | musashi RNA-binding protein 2 | -0.0897836 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0863074 |
| FN1 | fibronectin 1 | -0.0851521 |
| MMP1 | matrix metallopeptidase 1 | -0.0830437 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0829513 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0823648 |
| WASF2 | WAS protein family, member 2 | -0.0792782 |
| PGK1 | phosphoglycerate kinase 1 | -0.0791295 |
| LMO7 | LIM domain 7 | -0.0784611 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0766164 |
| MED13L | mediator complex subunit 13-like | -0.0728898 |
| PRELID2 | PRELI domain containing 2 | -0.0680082 |
| B2M | beta-2-microglobulin | -0.0673923 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0672449 |
| IGF2 | insulin-like growth factor 2 | -0.0649612 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0621461 |
| GPHN | gephyrin | -0.0617703 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0605247 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0574076 |
| BPTF | bromodomain PHD finger transcription factor | -0.0572073 |
| EGFR | epidermal growth factor receptor | -0.0565949 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0564032 |
| RPL19 | ribosomal protein L19 | -0.0555308 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0537846 |
| CSTB | cystatin B (stefin B) | -0.0537658 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0524536 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0517872 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.051014 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0505846 |
| FAT1 | FAT atypical cadherin 1 | -0.0504757 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.049758 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0489039 |
| ASPH | aspartate beta-hydroxylase | -0.0485507 |
| S100A9 | S100 calcium binding protein A9 | -0.0477274 |
| SQSTM1 | sequestosome 1 | -0.0463243 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0455949 |
| NUP98 | nucleoporin 98kDa | -0.0443212 |
| DENND1A | DENN/MADD domain containing 1A | -0.044308 |
| SBF2 | SET binding factor 2 | -0.0440711 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0435293 |
| RPS8 | ribosomal protein S8 | -0.0430223 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0425145 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0422171 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0419518 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0417743 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0412538 |
| NF1 | neurofibromin 1 | -0.0406998 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0402167 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0397624 |
| ATOSA | atos homolog A | -0.0396598 |
| SMYD3 | SET and MYND domain containing 3 | -0.039082 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0390706 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0379985 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0377322 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0374927 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0373539 |
| RPL35A | ribosomal protein L35a | -0.0367404 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0353643 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0349321 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0342309 |
| RPS13 | ribosomal protein S13 | -0.0337656 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0334038 |
| ABHD17C | abhydrolase domain containing 17C | -0.0329752 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0329264 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0322617 |
| ZNF638 | zinc finger protein 638 | -0.0315133 |
| FOXP1 | forkhead box P1 | -0.0312198 |
| RPL38 | ribosomal protein L38 | -0.030561 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.030533 |
| RBM25 | RNA binding motif protein 25 | -0.0303717 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0298253 |
| RPS11 | ribosomal protein S11 | -0.0297991 |
| LAMC2 | laminin, gamma 2 | -0.0296577 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0292096 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0291043 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0290238 |
| NAV2 | neuron navigator 2 | -0.0287268 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0284244 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0280783 |
| RPS3 | ribosomal protein S3 | -0.0279706 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0271132 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0265938 |
| ATXN1 | ataxin 1 | -0.0263557 |
| SFTPA2 | surfactant protein A2 | -0.0255052 |
| RAI14 | retinoic acid induced 14 | -0.0246886 |
| HLA-A | major histocompatibility complex, class I, A | -0.0233253 |
| FAM13A | family with sequence similarity 13, member A | -0.0227776 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0226478 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0224323 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0219578 |
| RREB1 | ras responsive element binding protein 1 | -0.0216931 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0215533 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0213213 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0213156 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0211084 |
| SLMAP | sarcolemma associated protein | -0.0208027 |
