| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.143404 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.11396 |
| TXNRD1 | thioredoxin reductase 1 | 0.102997 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0827808 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0825927 |
| MCL1 | myeloid cell leukemia 1 | 0.0819902 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0774462 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0723623 |
| BRD2 | bromodomain containing 2 | 0.0683267 |
| PCBP2 | poly(rC) binding protein 2 | 0.0645223 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0631672 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0624566 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0609401 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0562857 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0543747 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0535157 |
| RPL37 | ribosomal protein L37 | 0.0521189 |
| TPI1 | triosephosphate isomerase 1 | 0.0507182 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0493671 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0467071 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0466877 |
| GRAMD1B | GRAM domain containing 1B | 0.0459825 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0422672 |
| SFPQ | splicing factor proline/glutamine-rich | 0.040952 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.040175 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.040079 |
| MSN | moesin | 0.039716 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0394825 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0393414 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0376709 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0375796 |
| INTS6 | integrator complex subunit 6 | 0.0370208 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0361393 |
| RTN4 | reticulon 4 | 0.0358014 |
| IPO7 | importin 7 | 0.0357348 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0356681 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0354763 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0348698 |
| ATP11A | ATPase, class VI, type 11A | 0.0345223 |
| RPS12 | ribosomal protein S12 | 0.0343635 |
| CCNL1 | cyclin L1 | 0.0341324 |
| RPL3 | ribosomal protein L3 | 0.0333427 |
| UBC | ubiquitin C | 0.0330753 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0326113 |
| NABP1 | nucleic acid binding protein 1 | 0.0322536 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0322342 |
| SETD5 | SET domain containing 5 | 0.0321134 |
| RPS7 | ribosomal protein S7 | 0.0321037 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0316847 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0316204 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0312896 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0312752 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0311426 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0308974 |
| ANO6 | anoctamin 6 | 0.0302329 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0301082 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0300995 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0294505 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0288256 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0287336 |
| TPM3 | tropomyosin 3 | 0.0286654 |
| RBM39 | RNA binding motif protein 39 | 0.028235 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0280774 |
| CMIP | c-Maf inducing protein | 0.0278884 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0273741 |
| PNN | pinin, desmosome associated protein | 0.0266727 |
| PLEC | plectin | 0.0266684 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0265356 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.026518 |
| PGK1 | phosphoglycerate kinase 1 | 0.0264902 |
| HOMER1 | homer scaffolding protein 1 | 0.0260349 |
| JMJD1C | jumonji domain containing 1C | 0.0260303 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0256155 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0255257 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0254542 |
| ATXN2 | ataxin 2 | 0.0253308 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0251954 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.025156 |
| SCFD1 | sec1 family domain containing 1 | 0.0248419 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0245602 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0245553 |
| ETNK1 | ethanolamine kinase 1 | 0.0245463 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0245265 |
| DENR | density-regulated protein | 0.0243348 |
| GPHN | gephyrin | 0.0241737 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0239776 |
| PARD3 | par-3 family cell polarity regulator | 0.0239197 |
| PFDN2 | prefoldin subunit 2 | 0.0238702 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0237997 |
| CRY1 | cryptochrome circadian clock 1 | 0.0236032 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.023573 |
| MSH6 | mutS homolog 6 | 0.0232164 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0231428 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0229187 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0226568 |
| RPS10 | ribosomal protein S10 | 0.0226552 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0226172 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0225004 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0224895 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0224807 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.208586 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.168039 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.157581 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.104966 |
| PTMA | prothymosin, alpha | -0.099726 |
| TMSB10 | thymosin beta 10 | -0.0942007 |
| VIM | vimentin | -0.0843505 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0765878 |
| OSMR | oncostatin M receptor | -0.0640858 |
| CANX | calnexin | -0.0628452 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0567619 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0549019 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0536504 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0500799 |
| HLA-B | major histocompatibility complex, class I, B | -0.0495158 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0479568 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0472774 |
| AHNAK | AHNAK nucleoprotein | -0.0466388 |
| GNAS | GNAS complex locus | -0.0461263 |
| RYR3 | ryanodine receptor 3 | -0.0459355 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0456083 |
| TPM4 | tropomyosin 4 | -0.0450761 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0438207 |
| CAVIN1 | caveolae associated protein 1 | -0.0423201 |
| VCL | vinculin | -0.0418982 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0417236 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0415433 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.041479 |
| IER3 | immediate early response 3 | -0.0414303 |
| ATXN1 | ataxin 1 | -0.0398333 |
| SRP72 | signal recognition particle 72kDa | -0.039794 |
| HMGA2 | high mobility group AT-hook 2 | -0.0393748 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0392644 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0386613 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0370223 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0369219 |
| RPL34 | ribosomal protein L34 | -0.0351187 |
| RPL38 | ribosomal protein L38 | -0.0338796 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0331099 |
| CUX1 | cut-like homeobox 1 | -0.0331091 |
| ACTG1 | actin gamma 1 | -0.0329528 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0321663 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0317934 |
| RNF213 | ring finger protein 213 | -0.0314653 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0312153 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0307912 |
| FMN1 | formin 1 | -0.0307215 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0306488 |
| UBB | ubiquitin B | -0.030606 |
| RPS24 | ribosomal protein S24 | -0.0305102 |
| CLDN1 | claudin 1 | -0.030181 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0301449 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0296465 |
| FNDC3B | fibronectin type III domain containing 3B | -0.029564 |
| RPS21 | ribosomal protein S21 | -0.029253 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0291034 |
| CD2AP | CD2-associated protein | -0.0283483 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0283255 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0283145 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0282772 |
| EGFR | epidermal growth factor receptor | -0.0282534 |
| ZFR | zinc finger RNA binding protein | -0.0281068 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0279541 |
| H1-0 | H1.0 linker histone | -0.0277757 |
| CALR | calreticulin | -0.0274817 |
| S100A10 | S100 calcium binding protein A10 | -0.0270303 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0264858 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0264341 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0261446 |
| DENND5B | DENN/MADD domain containing 5B | -0.0261367 |
| MYOF | myoferlin | -0.0254936 |
| AEBP2 | AE binding protein 2 | -0.0248407 |
| ZNF217 | zinc finger protein 217 | -0.0245594 |
| RPL26 | ribosomal protein L26 | -0.0244914 |
| RPL35A | ribosomal protein L35a | -0.0240341 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0237198 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0237054 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0230064 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0226697 |
| ETV6 | ets variant 6 | -0.0226506 |
| MAP4 | microtubule-associated protein 4 | -0.0226096 |
| BMP5 | bone morphogenetic protein 5 | -0.0225604 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0225454 |
| CENPF | centromere protein F, 350/400kDa | -0.0224841 |
| STC1 | stanniocalcin 1 | -0.0221294 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0220581 |
| S100A6 | S100 calcium binding protein A6 | -0.0219756 |
| DSPP | dentin sialophosphoprotein | -0.0218432 |
| ENO1 | enolase 1, (alpha) | -0.021654 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0215036 |
| ATG7 | autophagy related 7 | -0.0213157 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.021302 |
| EPAS1 | endothelial PAS domain protein 1 | -0.021218 |
| ANXA2 | annexin A2 | -0.0211876 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0209919 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0209455 |
| DEK | DEK proto-oncogene | -0.0208075 |
| BSG | basigin (Ok blood group) | -0.0202087 |
| TRIM9 | tripartite motif containing 9 | -0.0201634 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0201344 |
