| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.291049 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.255764 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.240982 |
| FTL | ferritin, light polypeptide | 0.2168 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.191343 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.136219 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.118735 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.109654 |
| S100A6 | S100 calcium binding protein A6 | 0.0980721 |
| LDHA | lactate dehydrogenase A | 0.0851533 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0718714 |
| RACK1 | receptor for activated C kinase 1 | 0.067343 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0640142 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0626734 |
| UBC | ubiquitin C | 0.0606447 |
| ENO1 | enolase 1, (alpha) | 0.0601278 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0544155 |
| ARRDC3 | arrestin domain containing 3 | 0.051372 |
| RPLP1 | ribosomal protein, large, P1 | 0.0506271 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0502486 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0497425 |
| ACTG1 | actin gamma 1 | 0.0488863 |
| YBX1 | Y box binding protein 1 | 0.0480373 |
| RPLP0 | ribosomal protein, large, P0 | 0.0471767 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0469604 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0463823 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0463154 |
| HMGA1 | high mobility group AT-hook 1 | 0.0448022 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0447532 |
| POTEF | POTE ankyrin domain family, member F | 0.0445494 |
| MSN | moesin | 0.0434516 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0426694 |
| TXNRD1 | thioredoxin reductase 1 | 0.0419291 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0408834 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0408518 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0406571 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0397719 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0380779 |
| S100A10 | S100 calcium binding protein A10 | 0.0380549 |
| PKM | pyruvate kinase, muscle | 0.0373493 |
| TMSB4X | thymosin beta 4, X-linked | 0.0365835 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0365184 |
| BRD2 | bromodomain containing 2 | 0.0364786 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0362709 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0359626 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0358123 |
| PCBP2 | poly(rC) binding protein 2 | 0.0352972 |
| LAMB3 | laminin, beta 3 | 0.035252 |
| NDRG1 | N-myc downstream regulated 1 | 0.0350817 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0348017 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0346454 |
| RPL30 | ribosomal protein L30 | 0.0342985 |
| CANX | calnexin | 0.0341563 |
| RPS2 | ribosomal protein S2 | 0.0339503 |
| FHIT | fragile histidine triad | 0.0336067 |
| KIAA1217 | KIAA1217 | 0.033275 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0330083 |
| TXNIP | thioredoxin interacting protein | 0.0329596 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0327018 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0325229 |
| EGR1 | early growth response 1 | 0.0323146 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0321864 |
| RPL8 | ribosomal protein L8 | 0.0317955 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0315956 |
| LDHB | lactate dehydrogenase B | 0.0312455 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.031196 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0309174 |
| TPM3 | tropomyosin 3 | 0.03091 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0307313 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0304521 |
| SGMS2 | sphingomyelin synthase 2 | 0.0302417 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0298883 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0298649 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0288672 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0287526 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0283407 |
| RYBP | RING1 and YY1 binding protein | 0.02794 |
| IL6ST | interleukin 6 signal transducer | 0.0278143 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0278057 |
| RUNX1 | runt-related transcription factor 1 | 0.0275689 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0275051 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0274949 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0274307 |
| TAGLN2 | transgelin 2 | 0.0273932 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0273906 |
| CTSB | cathepsin B | 0.0263527 |
| FN1 | fibronectin 1 | 0.0263057 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0261288 |
| VGLL3 | vestigial-like family member 3 | 0.0252667 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0251258 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0245943 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0245777 |
| RPL3 | ribosomal protein L3 | 0.0245324 |
| CCNI | cyclin I | 0.0242828 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0242556 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.024214 |
| G0S2 | G0/G1 switch 2 | 0.0241816 |
| DSPP | dentin sialophosphoprotein | 0.0241053 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0240711 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0240568 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS29 | ribosomal protein S29 | -0.112405 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.108613 |
| PTMA | prothymosin, alpha | -0.10726 |
| TMSB10 | thymosin beta 10 | -0.086325 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0764995 |
| RPLP2 | ribosomal protein, large, P2 | -0.0654846 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0619302 |
| RPL37A | ribosomal protein L37a | -0.0599886 |
| HLA-B | major histocompatibility complex, class I, B | -0.0570133 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0553988 |
| RPS23 | ribosomal protein S23 | -0.0551593 |
| RPL31 | ribosomal protein L31 | -0.0519295 |
| RPS25 | ribosomal protein S25 | -0.0506982 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0504321 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0467512 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0461692 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0434566 |
| LMO7 | LIM domain 7 | -0.0425736 |
| RPL36A | ribosomal protein L36a | -0.0418183 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0414463 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.040437 |
| RPL9 | ribosomal protein L9 | -0.0397194 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0393171 |
| MT2A | metallothionein 2A | -0.0381377 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0378005 |
| CCND1 | cyclin D1 | -0.0356765 |
| RPS27A | ribosomal protein S27a | -0.0351911 |
| RPL38 | ribosomal protein L38 | -0.0338074 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0318131 |
| RPS13 | ribosomal protein S13 | -0.0317819 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0316292 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0305916 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.030083 |
| RBM39 | RNA binding motif protein 39 | -0.029466 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0288933 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.028741 |
| RPS10 | ribosomal protein S10 | -0.0287051 |
| RPL36 | ribosomal protein L36 | -0.0281051 |
| RASA2 | RAS p21 protein activator 2 | -0.0279247 |
| RPS24 | ribosomal protein S24 | -0.027011 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0270097 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0264274 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0257841 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0255162 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0251729 |
| RPS15 | ribosomal protein S15 | -0.0245904 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0244778 |
| TMEM263 | transmembrane protein 263 | -0.0242555 |
| CAVIN1 | caveolae associated protein 1 | -0.0235483 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0235045 |
| TOP1 | topoisomerase (DNA) I | -0.0230486 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0229821 |
| RPS11 | ribosomal protein S11 | -0.0227033 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0226651 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.022638 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0225563 |
| RPS21 | ribosomal protein S21 | -0.0224919 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0222584 |
| VCL | vinculin | -0.0221566 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0219679 |
| HLA-A | major histocompatibility complex, class I, A | -0.0219568 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0216913 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0210709 |
| COPA | coatomer protein complex, subunit alpha | -0.0209917 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0207365 |
| CDC73 | cell division cycle 73 | -0.0207323 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0205914 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0203495 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.019827 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0197389 |
| RPL19 | ribosomal protein L19 | -0.0195648 |
| FAM3C | family with sequence similarity 3, member C | -0.0194977 |
| RPL36AL | ribosomal protein L36a-like | -0.0193745 |
| RPS3 | ribosomal protein S3 | -0.0192989 |
| COX6C | cytochrome c oxidase subunit VIc | -0.0192459 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0191974 |
| OGA | O-GlcNAcase | -0.0189623 |
| GNAS | GNAS complex locus | -0.0186362 |
| MAP4 | microtubule-associated protein 4 | -0.0184806 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0183593 |
| IER5 | immediate early response 5 | -0.0182294 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0180961 |
| CD2AP | CD2-associated protein | -0.0180536 |
| TFG | TRK-fused gene | -0.0180142 |
| ASPH | aspartate beta-hydroxylase | -0.0178527 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0177025 |
| MYO6 | myosin VI | -0.0176605 |
| NEK7 | NIMA-related kinase 7 | -0.0176452 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0175923 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0175776 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.0175245 |
| COL1A1 | collagen, type I, alpha 1 | -0.0175096 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0174457 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0174387 |
| WDFY3 | WD repeat and FYVE domain containing 3 | -0.0173842 |
| CLDN12 | claudin 12 | -0.0171467 |
| RPS17 | ribosomal protein S17 | -0.0170211 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0170083 |
| FRMD5 | FERM domain containing 5 | -0.0168685 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0166335 |
