| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.299518 |
| VIM | vimentin | 0.167812 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.163665 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.159256 |
| FTL | ferritin, light polypeptide | 0.152168 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.109071 |
| RPS6 | ribosomal protein S6 | 0.0987239 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0941044 |
| RPLP0 | ribosomal protein, large, P0 | 0.0919969 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0907158 |
| LDHA | lactate dehydrogenase A | 0.0865567 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0864638 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0749017 |
| RACK1 | receptor for activated C kinase 1 | 0.0712726 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0631891 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0627909 |
| PGK1 | phosphoglycerate kinase 1 | 0.0615384 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0585393 |
| FN1 | fibronectin 1 | 0.0555021 |
| S100A10 | S100 calcium binding protein A10 | 0.0553053 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0541558 |
| RPL11 | ribosomal protein L11 | 0.0540721 |
| MAP7 | microtubule-associated protein 7 | 0.0537923 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0525692 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0524956 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0520853 |
| RPL7A | ribosomal protein L7a | 0.0511848 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0492022 |
| PTMA | prothymosin, alpha | 0.048528 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0482987 |
| ASTN2 | astrotactin 2 | 0.0480648 |
| S100A6 | S100 calcium binding protein A6 | 0.0475045 |
| RPLP1 | ribosomal protein, large, P1 | 0.0473433 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0469255 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0466352 |
| RPS4X | ribosomal protein S4, X-linked | 0.0463682 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0454259 |
| KRT19 | keratin 19, type I | 0.0434699 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0429042 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0419009 |
| RPL34 | ribosomal protein L34 | 0.0411866 |
| RPL30 | ribosomal protein L30 | 0.0408537 |
| ANXA2 | annexin A2 | 0.0407417 |
| SQSTM1 | sequestosome 1 | 0.0404749 |
| FMNL2 | formin-like 2 | 0.0401606 |
| RPL12 | ribosomal protein L12 | 0.0395465 |
| RPS8 | ribosomal protein S8 | 0.0393407 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0389831 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0380988 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0378742 |
| CDH13 | cadherin 13 | 0.0375684 |
| RPL39 | ribosomal protein L39 | 0.0375179 |
| TXNIP | thioredoxin interacting protein | 0.0373891 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.03671 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0360676 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0356039 |
| TPI1 | triosephosphate isomerase 1 | 0.0349011 |
| PFN1 | profilin 1 | 0.0344388 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0340082 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0339788 |
| STC1 | stanniocalcin 1 | 0.0339578 |
| RPL10A | ribosomal protein L10a | 0.0336606 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0335567 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0333172 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0332762 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0332394 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0329169 |
| LMNA | lamin A/C | 0.0329033 |
| DSTN | destrin (actin depolymerizing factor) | 0.0325572 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0323648 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0321092 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0320993 |
| VDAC1 | voltage-dependent anion channel 1 | 0.03209 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0314638 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0313454 |
| SMAD2 | SMAD family member 2 | 0.0306027 |
| RPL21 | ribosomal protein L21 | 0.0301096 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0300326 |
| RPS5 | ribosomal protein S5 | 0.0295038 |
| GOLGA4 | golgin A4 | 0.0295004 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0294986 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0294911 |
| RPS2 | ribosomal protein S2 | 0.029368 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0283756 |
| RPL35A | ribosomal protein L35a | 0.0283622 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0282689 |
| CA12 | carbonic anhydrase XII | 0.0277106 |
| INTS6 | integrator complex subunit 6 | 0.0272563 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0266753 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0261489 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 0.0256191 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0255175 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 0.0254822 |
| EEF1B2 | eukaryotic translation elongation factor 1 beta 2 | 0.0253129 |
| GPC6 | glypican 6 | 0.0252054 |
| PYGL | phosphorylase, glycogen, liver | 0.0251613 |
| CD109 | CD109 molecule | 0.0251216 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.0248185 |
| YBX3 | Y box binding protein 3 | 0.0247749 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | 0.0246534 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0923592 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0825816 |
| GRAMD1B | GRAM domain containing 1B | -0.0768115 |
| TMSB10 | thymosin beta 10 | -0.0758827 |
| RPS29 | ribosomal protein S29 | -0.0748805 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0685768 |
| MT2A | metallothionein 2A | -0.0627719 |
| EFNA5 | ephrin-A5 | -0.0572104 |
| RPL37A | ribosomal protein L37a | -0.0464745 |
| RPS27A | ribosomal protein S27a | -0.0426831 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0424943 |
| PCBP3 | poly(rC) binding protein 3 | -0.0374386 |
| NEK7 | NIMA-related kinase 7 | -0.0372921 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0350254 |
| NRCAM | neuronal cell adhesion molecule | -0.0349319 |
| RPL36 | ribosomal protein L36 | -0.0344415 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0344284 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0320626 |
| ASPH | aspartate beta-hydroxylase | -0.0288997 |
| VCL | vinculin | -0.0275871 |
| AHNAK | AHNAK nucleoprotein | -0.027237 |
| TXNRD1 | thioredoxin reductase 1 | -0.0264828 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0255803 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0254538 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.025216 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0251226 |
| OGA | O-GlcNAcase | -0.0251115 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0245404 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0242059 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0241875 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0241397 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0240678 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0227662 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0227289 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0226142 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0223327 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0217754 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0215894 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0207657 |
| MCL1 | myeloid cell leukemia 1 | -0.0206356 |
| RPS17 | ribosomal protein S17 | -0.0203544 |
| IL6 | interleukin 6 | -0.0198491 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0197628 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0196032 |
| CCDC68 | coiled-coil domain containing 68 | -0.0193245 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0193018 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0188338 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0186996 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0185078 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0181967 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0180211 |
| RPLP2 | ribosomal protein, large, P2 | -0.0179929 |
| RHOB | ras homolog family member B | -0.0179696 |
| ATP5MG | ATP synthase membrane subunit g | -0.017938 |
| CENPF | centromere protein F, 350/400kDa | -0.0178919 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0176151 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.0175375 |
| RPS25 | ribosomal protein S25 | -0.0174958 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | -0.0169532 |
| RPL38 | ribosomal protein L38 | -0.0169469 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0168116 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.016462 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0163915 |
| OSMR | oncostatin M receptor | -0.0163834 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0163066 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0162689 |
| RTN1 | reticulon 1 | -0.0158993 |
| SRPK2 | SRSF protein kinase 2 | -0.0156819 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0156542 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0155287 |
| RHEB | Ras homolog enriched in brain | -0.0154424 |
| RBM39 | RNA binding motif protein 39 | -0.0152806 |
| ADIPOR1 | adiponectin receptor 1 | -0.0151114 |
| UNC5D | unc-5 homolog D (C. elegans) | -0.0151093 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0149748 |
| PRDX1 | peroxiredoxin 1 | -0.0148088 |
| APP | amyloid beta (A4) precursor protein | -0.0147615 |
| WDR26 | WD repeat domain 26 | -0.0146506 |
| VMP1 | vacuole membrane protein 1 | -0.0145643 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.014468 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0144438 |
| GLIS3 | GLIS family zinc finger 3 | -0.0144407 |
| HELZ | helicase with zinc finger | -0.0144377 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0142676 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0141476 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.0139173 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.0136325 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0135535 |
| FLNB | filamin B, beta | -0.01355 |
| RBM33 | RNA binding motif protein 33 | -0.0135411 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.0135275 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0134688 |
| GDA | guanine deaminase | -0.0133707 |
| KIF14 | kinesin family member 14 | -0.0131541 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0130472 |
| RPS21 | ribosomal protein S21 | -0.0130332 |
| CCND1 | cyclin D1 | -0.012961 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0128995 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0128315 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0127416 |
