| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.196021 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.142742 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.126115 |
| FRMD6 | FERM domain containing 6 | 0.107919 |
| HDAC9 | histone deacetylase 9 | 0.0836862 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0771833 |
| MCL1 | myeloid cell leukemia 1 | 0.0750169 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.073885 |
| JMJD1C | jumonji domain containing 1C | 0.0693231 |
| RPL7 | ribosomal protein L7 | 0.0668381 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0644317 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0567462 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0564747 |
| SGMS2 | sphingomyelin synthase 2 | 0.0553999 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0540547 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0497504 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0489253 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0456932 |
| INTS6 | integrator complex subunit 6 | 0.040588 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0403054 |
| LDHA | lactate dehydrogenase A | 0.0401391 |
| RPL7A | ribosomal protein L7a | 0.0397004 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0396162 |
| AGO2 | argonaute RISC catalytic component 2 | 0.039381 |
| RCOR1 | REST corepressor 1 | 0.0393416 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0375953 |
| STC1 | stanniocalcin 1 | 0.0366521 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0361625 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0352343 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0352001 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0350564 |
| CORO1C | coronin, actin binding protein, 1C | 0.0343518 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0324066 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0315898 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0305411 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0305195 |
| RPS8 | ribosomal protein S8 | 0.0305032 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0299642 |
| RACK1 | receptor for activated C kinase 1 | 0.0297362 |
| ACTG1 | actin gamma 1 | 0.0297127 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0293793 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0290255 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0281997 |
| HMGA2 | high mobility group AT-hook 2 | 0.0279633 |
| RPL8 | ribosomal protein L8 | 0.0276542 |
| GLRX | glutaredoxin (thioltransferase) | 0.0269117 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.026825 |
| UBC | ubiquitin C | 0.0265183 |
| EGR1 | early growth response 1 | 0.0263556 |
| NAV3 | neuron navigator 3 | 0.0261915 |
| ENO1 | enolase 1, (alpha) | 0.0258648 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0252582 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0251754 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0248207 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0246293 |
| RUNX1 | runt-related transcription factor 1 | 0.0244495 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0243025 |
| SETX | senataxin | 0.0242991 |
| CALU | calumenin | 0.0241253 |
| RPLP0 | ribosomal protein, large, P0 | 0.0240538 |
| CAPRIN2 | caprin family member 2 | 0.0237343 |
| RPL23 | ribosomal protein L23 | 0.0236722 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0235612 |
| RPL3 | ribosomal protein L3 | 0.0233414 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0230165 |
| FNIP1 | folliculin interacting protein 1 | 0.0228293 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0227198 |
| CLTC | clathrin, heavy chain (Hc) | 0.0225951 |
| CD68 | CD68 molecule | 0.0224088 |
| UPP1 | uridine phosphorylase 1 | 0.0222865 |
| SP100 | SP100 nuclear antigen | 0.0222433 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0218352 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0217406 |
| FTL | ferritin, light polypeptide | 0.0217167 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0216943 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0215136 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0215081 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0212295 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0210788 |
| PKM | pyruvate kinase, muscle | 0.0205098 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0203975 |
| SFPQ | splicing factor proline/glutamine-rich | 0.020238 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0199493 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0198302 |
| PGK1 | phosphoglycerate kinase 1 | 0.0197205 |
| DGKI | diacylglycerol kinase, iota | 0.01971 |
| NDRG1 | N-myc downstream regulated 1 | 0.0196726 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0193011 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0192159 |
| BRD2 | bromodomain containing 2 | 0.0191122 |
| RPS6 | ribosomal protein S6 | 0.0190932 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0187525 |
| JUN | jun proto-oncogene | 0.0185802 |
| VMP1 | vacuole membrane protein 1 | 0.0182605 |
| CUTC | cutC copper transporter | 0.0180582 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0180221 |
| ACTN1 | actinin, alpha 1 | 0.0179596 |
| RPS5 | ribosomal protein S5 | 0.017794 |
| TRAM1 | translocation associated membrane protein 1 | 0.0177532 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0176816 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.058245 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0440538 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0362815 |
| MT2A | metallothionein 2A | -0.0312232 |
| RBM25 | RNA binding motif protein 25 | -0.0287023 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0278972 |
| TCF12 | transcription factor 12 | -0.0266341 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0228468 |
| RAB3IP | RAB3A interacting protein | -0.0221192 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.021413 |
| MATR3 | matrin 3 | -0.0195759 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.018905 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0184818 |
| FLNB | filamin B, beta | -0.0183616 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0181013 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0174991 |
| CALD1 | caldesmon 1 | -0.0171363 |
| MTAP | methylthioadenosine phosphorylase | -0.0168881 |
| TMSB10 | thymosin beta 10 | -0.0166921 |
| TTR | transthyretin | -0.0166622 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0166367 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0160135 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0159407 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0157497 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0157339 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0155145 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0153803 |
| NSMAF | neutral sphingomyelinase (N-SMase) activation associated factor | -0.015335 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.015067 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0149997 |
| TXNRD1 | thioredoxin reductase 1 | -0.0149767 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0149445 |
| USP3 | ubiquitin specific peptidase 3 | -0.0149099 |
| LAMB3 | laminin, beta 3 | -0.0142296 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0139767 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0139363 |
| ZNF438 | zinc finger protein 438 | -0.0139309 |
| MT1X | metallothionein 1X | -0.0138449 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0137841 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | -0.0137823 |
| NF1 | neurofibromin 1 | -0.0134933 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0130735 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0129274 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0128905 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0128323 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0127716 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -0.0126867 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0125476 |
| CCDC91 | coiled-coil domain containing 91 | -0.0125214 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0125062 |
| CDK6 | cyclin-dependent kinase 6 | -0.0124752 |
| MAP4 | microtubule-associated protein 4 | -0.0124739 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.0124508 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0123635 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0123594 |
| CDC27 | cell division cycle 27 | -0.0123472 |
| TCERG1 | transcription elongation regulator 1 | -0.0123245 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0122587 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0122374 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0122095 |
| ANKRD28 | ankyrin repeat domain 28 | -0.012182 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0121286 |
| OGA | O-GlcNAcase | -0.0120447 |
| TRIM56 | tripartite motif containing 56 | -0.011625 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | -0.0115854 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0115682 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0115681 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | -0.0115571 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.011554 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0115221 |
| FHL2 | four and a half LIM domains 2 | -0.0114166 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.01133 |
| PDS5B | PDS5 cohesin associated factor B | -0.0112069 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0108748 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0108672 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0108607 |
| RPL38 | ribosomal protein L38 | -0.0107835 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.010683 |
| MKI67 | marker of proliferation Ki-67 | -0.0105639 |
| TMEM156 | transmembrane protein 156 | -0.0105123 |
| SIMC1 | SUMO-interacting motifs containing 1 | -0.0105029 |
| RFX7 | regulatory factor X, 7 | -0.0104878 |
| RBM26 | RNA binding motif protein 26 | -0.0104824 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0104226 |
| RPS21 | ribosomal protein S21 | -0.0102852 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0102235 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.010092 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | -0.0100737 |
| SRPK2 | SRSF protein kinase 2 | -0.00999918 |
| PRRC2B | proline-rich coiled-coil 2B | -0.00997499 |
| ITSN2 | intersectin 2 | -0.00971302 |
| FOXP1 | forkhead box P1 | -0.0096884 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.00968733 |
| FOXK2 | forkhead box K2 | -0.0096797 |
| PSMA1 | proteasome (prosome, macropain) subunit, alpha type, 1 | -0.00965848 |
| TBC1D4 | TBC1 domain family, member 4 | -0.00963228 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.00962785 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.00960591 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.00959885 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.00951073 |
