| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.219085 |
| STC1 | stanniocalcin 1 | 0.184847 |
| B2M | beta-2-microglobulin | 0.0852731 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0753636 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0730855 |
| NDRG1 | N-myc downstream regulated 1 | 0.0679117 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0673579 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.059049 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.058895 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.058499 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0567965 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0549092 |
| HDAC9 | histone deacetylase 9 | 0.051308 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0494555 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0481593 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.047934 |
| CD44 | CD44 molecule (Indian blood group) | 0.0467824 |
| SP100 | SP100 nuclear antigen | 0.0463972 |
| VEGFA | vascular endothelial growth factor A | 0.0461934 |
| LOXL2 | lysyl oxidase-like 2 | 0.0457333 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0442624 |
| PKM | pyruvate kinase, muscle | 0.0436425 |
| ASPH | aspartate beta-hydroxylase | 0.0423141 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0420782 |
| HLA-B | major histocompatibility complex, class I, B | 0.041915 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0417517 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0416373 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0408041 |
| MSN | moesin | 0.039771 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0394362 |
| CD109 | CD109 molecule | 0.0393465 |
| HLA-A | major histocompatibility complex, class I, A | 0.0373045 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0370028 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0367065 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0366961 |
| NRP1 | neuropilin 1 | 0.0353402 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0349079 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.034592 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0343697 |
| IFI44L | interferon-induced protein 44-like | 0.0340023 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0338817 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0330816 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0327324 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0321222 |
| SVIL | supervillin | 0.0312478 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0312329 |
| DSTN | destrin (actin depolymerizing factor) | 0.0311421 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0307948 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0307814 |
| COL5A3 | collagen, type V, alpha 3 | 0.030343 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0297951 |
| ECE1 | endothelin converting enzyme 1 | 0.0297915 |
| COL5A1 | collagen, type V, alpha 1 | 0.0294849 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0293994 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0293066 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0291822 |
| EML5 | echinoderm microtubule associated protein like 5 | 0.0289151 |
| DST | dystonin | 0.0284032 |
| LDHA | lactate dehydrogenase A | 0.0283536 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0279065 |
| RPS12 | ribosomal protein S12 | 0.0271173 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0271169 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.026454 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0263342 |
| JUN | jun proto-oncogene | 0.0262193 |
| FBXO32 | F-box protein 32 | 0.0261918 |
| MTSS1 | metastasis suppressor 1 | 0.025833 |
| ANGPTL4 | angiopoietin-like 4 | 0.025631 |
| RND3 | Rho family GTPase 3 | 0.0255473 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0252038 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0250803 |
| FAT1 | FAT atypical cadherin 1 | 0.0248532 |
| CLIC4 | chloride intracellular channel 4 | 0.0247473 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0245016 |
| MCL1 | myeloid cell leukemia 1 | 0.0244064 |
| HLA-E | major histocompatibility complex, class I, E | 0.0243823 |
| RPS25 | ribosomal protein S25 | 0.0243608 |
| NAV1 | neuron navigator 1 | 0.0243486 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0242686 |
| MMP2 | matrix metallopeptidase 2 | 0.0240721 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0236823 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0234238 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0230524 |
| TPM1 | tropomyosin 1 (alpha) | 0.0230353 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.022868 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.022829 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0228145 |
| SQSTM1 | sequestosome 1 | 0.0227161 |
| KIAA1217 | KIAA1217 | 0.0225025 |
| ATP13A3 | ATPase type 13A3 | 0.0224177 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0221471 |
| INHBA | inhibin, beta A | 0.0221423 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0220682 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0220674 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0219883 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0219821 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0219196 |
| FTL | ferritin, light polypeptide | 0.0218367 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0215599 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0212676 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0875036 |
| VIM | vimentin | -0.0552412 |
| PTMA | prothymosin, alpha | -0.0507786 |
| RPLP1 | ribosomal protein, large, P1 | -0.0414568 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0301626 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0276031 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0255123 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0226146 |
| RPL35A | ribosomal protein L35a | -0.0220617 |
| RPL34 | ribosomal protein L34 | -0.0212559 |
| RRBP1 | ribosome binding protein 1 | -0.0209235 |
| ANLN | anillin, actin binding protein | -0.0199511 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0195428 |
| HMGB2 | high mobility group box 2 | -0.0188337 |
| LMNA | lamin A/C | -0.0187206 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0185369 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.018071 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.017573 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | -0.0174804 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0168492 |
| MT2A | metallothionein 2A | -0.0167023 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.016006 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.016003 |
| SELENOK | selenoprotein K | -0.0159448 |
| FAM162A | family with sequence similarity 162, member A | -0.015925 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0146482 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0142731 |
| SEC24D | SEC24 family member D | -0.0141766 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | -0.0139621 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0137678 |
| MORF4L2 | mortality factor 4 like 2 | -0.0136785 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0134695 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0134421 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0133592 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0132244 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0131238 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0130927 |
| TMSB10 | thymosin beta 10 | -0.0129729 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0128902 |
| HMGB1 | high mobility group box 1 | -0.0127138 |
| AAK1 | AP2 associated kinase 1 | -0.0126346 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0124717 |
| RTN4 | reticulon 4 | -0.0123845 |
| USP3 | ubiquitin specific peptidase 3 | -0.0123045 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.0122038 |
| COPS2 | COP9 signalosome subunit 2 | -0.0119752 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0119382 |
| CCDC47 | coiled-coil domain containing 47 | -0.0118748 |
| ABI1 | abl-interactor 1 | -0.0117893 |
| FRMD4A | FERM domain containing 4A | -0.011789 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0117782 |
| SEC61G | Sec61 gamma subunit | -0.0113623 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0111653 |
| TMEM263 | transmembrane protein 263 | -0.0110629 |
| RAB6A | RAB6A, member RAS oncogene family | -0.011057 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0109384 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0109144 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0108376 |
| MYL12B | myosin, light chain 12B, regulatory | -0.010833 |
| GANAB | glucosidase, alpha; neutral AB | -0.010779 |
| THBS1 | thrombospondin 1 | -0.0107472 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0105314 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0103838 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0103832 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0103602 |
| MKI67 | marker of proliferation Ki-67 | -0.0103593 |
| SERF2 | small EDRK-rich factor 2 | -0.0103422 |
| RPL12 | ribosomal protein L12 | -0.0103302 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0103121 |
| CEP95 | centrosomal protein 95kDa | -0.010267 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0102067 |
| TPD52 | tumor protein D52 | -0.0101668 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0100877 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.00999014 |
| POM121 | POM121 transmembrane nucleoporin | -0.00996986 |
| KANTR | KDM5C adjacent non-coding transcript | -0.0098805 |
| MT1X | metallothionein 1X | -0.00987609 |
| GNAS | GNAS complex locus | -0.00987372 |
| CKAP5 | cytoskeleton associated protein 5 | -0.00984779 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00980416 |
| PRR11 | proline rich 11 | -0.00975306 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0096944 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.00965829 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0096134 |
| SCFD2 | sec1 family domain containing 2 | -0.00957223 |
| GYS1 | glycogen synthase 1 (muscle) | -0.00956909 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.00955384 |
| PARK7 | parkinson protein 7 | -0.00953432 |
| CCNB2 | cyclin B2 | -0.00953278 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.00952348 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | -0.00947936 |
| HJURP | Holliday junction recognition protein | -0.00936394 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.00932275 |
| ARMC9 | armadillo repeat containing 9 | -0.00930169 |
| PTGES2 | prostaglandin E synthase 2 | -0.009284 |
| ZNF609 | zinc finger protein 609 | -0.00927147 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.00924003 |
| NUP214 | nucleoporin 214kDa | -0.00921215 |
| RBM39 | RNA binding motif protein 39 | -0.00913939 |
| NBAS | neuroblastoma amplified sequence | -0.00911258 |
