| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.102619 |
| GPC6 | glypican 6 | 0.0705404 |
| STC1 | stanniocalcin 1 | 0.0668093 |
| INHBA | inhibin, beta A | 0.062378 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0570351 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0497179 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0489266 |
| NBEA | neurobeachin | 0.0478645 |
| CNKSR3 | CNKSR family member 3 | 0.0477298 |
| CPE | carboxypeptidase E | 0.0463165 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | 0.0457555 |
| SCG2 | secretogranin II | 0.043164 |
| SNTG1 | syntrophin, gamma 1 | 0.0424504 |
| NCKAP5 | NCK-associated protein 5 | 0.0413472 |
| NRG1 | neuregulin 1 | 0.0413153 |
| ACTG1 | actin gamma 1 | 0.0407639 |
| MAP1B | microtubule-associated protein 1B | 0.0397478 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0388294 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0386154 |
| PTCHD4 | patched domain containing 4 | 0.0368106 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0365522 |
| CALCA | calcitonin-related polypeptide alpha | 0.0343279 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0341663 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.0333215 |
| EGR1 | early growth response 1 | 0.0327379 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0321402 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0311795 |
| KIF26B | kinesin family member 26B | 0.0308452 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0304566 |
| CHGA | chromogranin A | 0.030049 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0289774 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0285887 |
| FTL | ferritin, light polypeptide | 0.028284 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0279757 |
| SVIL | supervillin | 0.0271333 |
| SCFD1 | sec1 family domain containing 1 | 0.0270838 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0270809 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.02691 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0267576 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0266272 |
| TOX | thymocyte selection-associated high mobility group box | 0.0259625 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0255657 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0254823 |
| ASPH | aspartate beta-hydroxylase | 0.0252914 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0252394 |
| GPATCH2L | G patch domain containing 2-like | 0.0249041 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0248822 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0248264 |
| ZFHX3 | zinc finger homeobox 3 | 0.0232922 |
| SMYD3 | SET and MYND domain containing 3 | 0.02304 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.02301 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | 0.0229982 |
| FGF14 | fibroblast growth factor 14 | 0.0228443 |
| DSTN | destrin (actin depolymerizing factor) | 0.0225661 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0224887 |
| RORA | RAR-related orphan receptor A | 0.0224219 |
| GPATCH8 | G patch domain containing 8 | 0.0223571 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.022245 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0220449 |
| KLHL29 | kelch-like family member 29 | 0.0218362 |
| RALYL | RALY RNA binding protein-like | 0.0210898 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | 0.0206624 |
| COL22A1 | collagen, type XXII, alpha 1 | 0.0205559 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0204859 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0204578 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.02044 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0200174 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 0.0196477 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0192132 |
| LSAMP | limbic system-associated membrane protein | 0.0191028 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0189347 |
| MCL1 | myeloid cell leukemia 1 | 0.018848 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0188279 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.018809 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0188018 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0187869 |
| KHDRBS2 | KH domain containing, RNA binding, signal transduction associated 2 | 0.0186261 |
| NANOS1 | nanos homolog 1 (Drosophila) | 0.0186168 |
| RPL11 | ribosomal protein L11 | 0.0185515 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | 0.0182859 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0180922 |
| RPS6 | ribosomal protein S6 | 0.0180739 |
| RPL37 | ribosomal protein L37 | 0.0179853 |
| HM13 | histocompatibility (minor) 13 | 0.0179477 |
| ZNF804A | zinc finger protein 804A | 0.0179105 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0178081 |
| HOMER1 | homer scaffolding protein 1 | 0.0176601 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0175969 |
| GPC5 | glypican 5 | 0.0174185 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | 0.0172389 |
| CNTNAP5 | contactin associated protein-like 5 | 0.017116 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0170503 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0170344 |
| IRS2 | insulin receptor substrate 2 | 0.01682 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | 0.0167983 |
| NDRG1 | N-myc downstream regulated 1 | 0.0167659 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0166916 |
| SIK2 | salt-inducible kinase 2 | 0.0166859 |
| PHF14 | PHD finger protein 14 | 0.0166804 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0165828 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TENM1 | teneurin transmembrane protein 1 | -0.0910784 |
| PTMA | prothymosin, alpha | -0.0847189 |
| PDE10A | phosphodiesterase 10A | -0.0758509 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0572232 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0531599 |
| MATR3 | matrin 3 | -0.048884 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0473185 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0461117 |
| PEG10 | paternally expressed 10 | -0.0426327 |
| RPS27A | ribosomal protein S27a | -0.0419974 |
| UBC | ubiquitin C | -0.0360888 |
| CENPF | centromere protein F, 350/400kDa | -0.0351607 |
| SET | SET nuclear proto-oncogene | -0.034485 |
| VGF | VGF nerve growth factor inducible | -0.03369 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0333111 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0332895 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0314675 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0302615 |
| HMGB2 | high mobility group box 2 | -0.0282099 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.027944 |
| ENO1 | enolase 1, (alpha) | -0.0278711 |
| XPO1 | exportin 1 | -0.027654 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0267087 |
| NUF2 | NUF2, NDC80 kinetochore complex component | -0.0266375 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0262596 |
| PCBP2 | poly(rC) binding protein 2 | -0.0261757 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0258811 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0258022 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0251965 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0246371 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0236155 |
| TPX2 | TPX2, microtubule-associated | -0.0233597 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0232512 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0228681 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0221585 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0207001 |
| TXNIP | thioredoxin interacting protein | -0.0205912 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0200784 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0197674 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0192172 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.0190757 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0186236 |
| ECT2 | epithelial cell transforming 2 | -0.0186135 |
| NFIA | nuclear factor I/A | -0.0183768 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | -0.0183557 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.0181878 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0179973 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0179325 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0178588 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0176821 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0176628 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0175686 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0175213 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0174743 |
| OGA | O-GlcNAcase | -0.0173888 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.0173415 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | -0.0171899 |
| PHIP | pleckstrin homology domain interacting protein | -0.0170526 |
| RTN4 | reticulon 4 | -0.0170203 |
| MYEF2 | myelin expression factor 2 | -0.0170024 |
| CCNB1 | cyclin B1 | -0.0169803 |
| NCAM1 | neural cell adhesion molecule 1 | -0.0168697 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0168491 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0167209 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0164106 |
| TPM3 | tropomyosin 3 | -0.0163008 |
| NCKAP1 | NCK-associated protein 1 | -0.0159337 |
| NBAS | neuroblastoma amplified sequence | -0.0157984 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0157763 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.0156509 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0154987 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0153341 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | -0.0151462 |
| CERS2 | ceramide synthase 2 | -0.0150696 |
| ZNF292 | zinc finger protein 292 | -0.0150593 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0150307 |
| MTMR7 | myotubularin related protein 7 | -0.0149382 |
| KDM1A | lysine (K)-specific demethylase 1A | -0.0149242 |
| RPL23 | ribosomal protein L23 | -0.014845 |
| SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | -0.0148445 |
| DIAPH3 | diaphanous-related formin 3 | -0.0147338 |
| TPD52 | tumor protein D52 | -0.0147197 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0146441 |
| TMSB10 | thymosin beta 10 | -0.0146399 |
| MED13L | mediator complex subunit 13-like | -0.0145879 |
| SPAG9 | sperm associated antigen 9 | -0.0145875 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.0145762 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0145586 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0144989 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.014498 |
| RACGAP1 | Rac GTPase activating protein 1 | -0.0143317 |
| RPL4 | ribosomal protein L4 | -0.0143254 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0140331 |
| PBK | PDZ binding kinase | -0.0139709 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0139377 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0139088 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0138744 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | -0.013874 |
| CADM1 | cell adhesion molecule 1 | -0.0137526 |
| LIFR | leukemia inhibitory factor receptor alpha | -0.0135836 |
