| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0789564 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0469446 |
| LDHA | lactate dehydrogenase A | 0.0457562 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0393957 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0356126 |
| MSN | moesin | 0.0327951 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0293819 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0279188 |
| ASPH | aspartate beta-hydroxylase | 0.026101 |
| UBC | ubiquitin C | 0.0250899 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0235819 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0232851 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.023166 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0230288 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0228443 |
| AMOTL1 | angiomotin like 1 | 0.0226995 |
| FMNL2 | formin-like 2 | 0.0220885 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0210367 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0210363 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0209797 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0207258 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0199193 |
| RUNX1 | runt-related transcription factor 1 | 0.0198752 |
| FLNA | filamin A, alpha | 0.0193812 |
| SQSTM1 | sequestosome 1 | 0.0187562 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0187048 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0184651 |
| ANGPTL4 | angiopoietin-like 4 | 0.0182916 |
| ANXA2 | annexin A2 | 0.0176637 |
| CDK6 | cyclin-dependent kinase 6 | 0.0176325 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0175812 |
| CLIC4 | chloride intracellular channel 4 | 0.0175498 |
| CANX | calnexin | 0.0173967 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0172716 |
| ACTN1 | actinin, alpha 1 | 0.0172534 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0169737 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0169721 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0169663 |
| PKM | pyruvate kinase, muscle | 0.0168561 |
| SPAG9 | sperm associated antigen 9 | 0.0164816 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0164483 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0161447 |
| DST | dystonin | 0.0160167 |
| SCARB2 | scavenger receptor class B, member 2 | 0.015932 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0157996 |
| HDAC9 | histone deacetylase 9 | 0.0156561 |
| ENO1 | enolase 1, (alpha) | 0.0156205 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0154487 |
| FLNB | filamin B, beta | 0.015441 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0153424 |
| INPP5F | inositol polyphosphate-5-phosphatase F | 0.0152602 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0150052 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0148525 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0148297 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0147502 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0145823 |
| OXSR1 | oxidative stress responsive 1 | 0.0144462 |
| NOTCH2 | notch 2 | 0.0143926 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0139688 |
| PGK1 | phosphoglycerate kinase 1 | 0.0138861 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0137816 |
| CCND1 | cyclin D1 | 0.0137324 |
| GOLGB1 | golgin B1 | 0.0136778 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0136276 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.01354 |
| SON | SON DNA binding protein | 0.0134791 |
| SMAD3 | SMAD family member 3 | 0.0133445 |
| TPI1 | triosephosphate isomerase 1 | 0.0133389 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0130132 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0129583 |
| KIF5B | kinesin family member 5B | 0.0129036 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0129031 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0128928 |
| COG5 | component of oligomeric golgi complex 5 | 0.0128558 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0128276 |
| IL6ST | interleukin 6 signal transducer | 0.0125929 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0124718 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0124634 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0124 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0119774 |
| SFTPA2 | surfactant protein A2 | 0.0119233 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0118366 |
| AFDN | afadin, adherens junction formation factor | 0.0115445 |
| RYBP | RING1 and YY1 binding protein | 0.0115271 |
| CD44 | CD44 molecule (Indian blood group) | 0.0114708 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0113886 |
| EMP1 | epithelial membrane protein 1 | 0.0113696 |
| CTSB | cathepsin B | 0.0113569 |
| SSH1 | slingshot protein phosphatase 1 | 0.0111745 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0110499 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0110434 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0110298 |
| RPL3 | ribosomal protein L3 | 0.0110207 |
| SP100 | SP100 nuclear antigen | 0.011011 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0109245 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0109085 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0108904 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0108675 |
| CENPF | centromere protein F, 350/400kDa | 0.0107719 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0107676 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.0852799 |
| MT2A | metallothionein 2A | -0.0731407 |
| LSAMP | limbic system-associated membrane protein | -0.0645096 |
| TMSB10 | thymosin beta 10 | -0.0586374 |
| RPL35A | ribosomal protein L35a | -0.053531 |
| RPLP1 | ribosomal protein, large, P1 | -0.0483845 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0474666 |
| NRG3 | neuregulin 3 | -0.044141 |
| PTMA | prothymosin, alpha | -0.0396608 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.035347 |
| RPS6 | ribosomal protein S6 | -0.0329071 |
| FTL | ferritin, light polypeptide | -0.0321403 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0316873 |
| RPL34 | ribosomal protein L34 | -0.0277745 |
| RPS21 | ribosomal protein S21 | -0.0274298 |
| MT1X | metallothionein 1X | -0.0256433 |
| RPL12 | ribosomal protein L12 | -0.0255557 |
| RPL23 | ribosomal protein L23 | -0.0231629 |
| RPL37A | ribosomal protein L37a | -0.0226953 |
| VIM | vimentin | -0.0225121 |
| FRMD4A | FERM domain containing 4A | -0.0213987 |
| S100A9 | S100 calcium binding protein A9 | -0.019881 |
| RPS12 | ribosomal protein S12 | -0.0190183 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0183836 |
| RPL38 | ribosomal protein L38 | -0.0180225 |
| RPL36 | ribosomal protein L36 | -0.0177006 |
| FMN1 | formin 1 | -0.017503 |
| RPS23 | ribosomal protein S23 | -0.0172999 |
| RPS29 | ribosomal protein S29 | -0.0170759 |
| RPLP2 | ribosomal protein, large, P2 | -0.0170266 |
| RPS3 | ribosomal protein S3 | -0.0169197 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0162171 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0162015 |
| KAZN | kazrin, periplakin interacting protein | -0.0161941 |
| RPL36A | ribosomal protein L36a | -0.0160486 |
| RPS14 | ribosomal protein S14 | -0.015345 |
| RPS19 | ribosomal protein S19 | -0.0151566 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0151015 |
| RAD51B | RAD51 paralog B | -0.0150607 |
| RPS27A | ribosomal protein S27a | -0.0150433 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0143714 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0140163 |
| POTEF | POTE ankyrin domain family, member F | -0.0138389 |
| RPL27 | ribosomal protein L27 | -0.0136777 |
| PRAME | preferentially expressed antigen in melanoma | -0.0136465 |
| FHIT | fragile histidine triad | -0.0135758 |
| POLR2F | polymerase (RNA) II (DNA directed) polypeptide F | -0.0131454 |
| RPS8 | ribosomal protein S8 | -0.0129861 |
| RPS13 | ribosomal protein S13 | -0.0127823 |
| RPS24 | ribosomal protein S24 | -0.0127673 |
| RPL19 | ribosomal protein L19 | -0.0126783 |
| RPL28 | ribosomal protein L28 | -0.0125297 |
| RPL26 | ribosomal protein L26 | -0.0124821 |
| RPL31 | ribosomal protein L31 | -0.0121764 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0118646 |
| S100A6 | S100 calcium binding protein A6 | -0.0117311 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0116498 |
| RPL35 | ribosomal protein L35 | -0.0115853 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0113749 |
| LAMTOR5 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 | -0.0110635 |
| RPL32 | ribosomal protein L32 | -0.0110066 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0109409 |
| RPL27A | ribosomal protein L27a | -0.0108449 |
| ICAM1 | intercellular adhesion molecule 1 | -0.010716 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0100425 |
| COMMD10 | COMM domain containing 10 | -0.0100279 |
| RPL5 | ribosomal protein L5 | -0.0100071 |
| RPS20 | ribosomal protein S20 | -0.0099772 |
| RPL37 | ribosomal protein L37 | -0.00997459 |
| RPS27 | ribosomal protein S27 | -0.00994438 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.00993056 |
| UBL5 | ubiquitin-like 5 | -0.00971914 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.00956614 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00954425 |
| ATF4 | activating transcription factor 4 | -0.00951569 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.00922673 |
| XPNPEP3 | X-prolyl aminopeptidase 3, mitochondrial | -0.00904715 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.00903675 |
| GOLGA4 | golgin A4 | -0.00896992 |
| LOC112694756 | uncharaterized LOC112694756 | -0.00890215 |
| RPS16 | ribosomal protein S16 | -0.00880473 |
| SEC61G | Sec61 gamma subunit | -0.00878212 |
| GNAS | GNAS complex locus | -0.00867456 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.00864764 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.00857654 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.00856824 |
| RPL9 | ribosomal protein L9 | -0.00849601 |
| RAB7A | RAB7A, member RAS oncogene family | -0.00842349 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.00837607 |
| RPS11 | ribosomal protein S11 | -0.00835476 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.00818555 |
| SNU13 | small nuclear ribonucleoprotein 13 | -0.00809321 |
| KPNB1 | karyopherin (importin) beta 1 | -0.00808669 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | -0.0080385 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.00801596 |
| HMGB1 | high mobility group box 1 | -0.00795302 |
| THOC2 | THO complex 2 | -0.00788819 |
| CADM1 | cell adhesion molecule 1 | -0.00771443 |
| MYL12B | myosin, light chain 12B, regulatory | -0.00769054 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.00763803 |
