| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.196785 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.165834 |
| HDAC9 | histone deacetylase 9 | 0.131368 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.125351 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 0.121926 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.116557 |
| ANXA1 | annexin A1 | 0.111886 |
| BMP10 | bone morphogenetic protein 10 | 0.110343 |
| VCL | vinculin | 0.104968 |
| PKM | pyruvate kinase, muscle | 0.102923 |
| FOXP1 | forkhead box P1 | 0.102438 |
| EGFR | epidermal growth factor receptor | 0.102348 |
| AHNAK | AHNAK nucleoprotein | 0.0947752 |
| TJP1 | tight junction protein 1 | 0.0933845 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0775785 |
| GLI3 | GLI family zinc finger 3 | 0.072675 |
| EZR | ezrin | 0.0712935 |
| GSE1 | Gse1 coiled-coil protein | 0.0558866 |
| MKI67 | marker of proliferation Ki-67 | 0.050872 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.050393 |
| TMEM65 | transmembrane protein 65 | 0.0491592 |
| GLI2 | GLI family zinc finger 2 | 0.0481382 |
| NBEA | neurobeachin | 0.0470257 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0438161 |
| MYO5C | myosin VC | 0.0428278 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0424439 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0406749 |
| FER1L6 | fer-1-like family member 6 | 0.0402487 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.0398828 |
| FLNB | filamin B, beta | 0.0398468 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0394013 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0393543 |
| DIAPH3 | diaphanous-related formin 3 | 0.038842 |
| SEPTIN9 | septin 9 | 0.0384292 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0360093 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0355078 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0353195 |
| PYGB | phosphorylase, glycogen; brain | 0.0348115 |
| ZNF438 | zinc finger protein 438 | 0.0348081 |
| ZNF608 | zinc finger protein 608 | 0.0347906 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0346773 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0345883 |
| PDGFC | platelet derived growth factor C | 0.0339876 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0338748 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0337463 |
| RPL3 | ribosomal protein L3 | 0.0328958 |
| CCND1 | cyclin D1 | 0.0328071 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0327812 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0327409 |
| TXNRD1 | thioredoxin reductase 1 | 0.0326038 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0325276 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0324872 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0322658 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0322438 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0320984 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0320941 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.031981 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0316474 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0300175 |
| DUSP4 | dual specificity phosphatase 4 | 0.0295308 |
| FAT1 | FAT atypical cadherin 1 | 0.0293344 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0287343 |
| CUX1 | cut-like homeobox 1 | 0.0284189 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0282733 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0282099 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.0279035 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0274145 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0272367 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0270091 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0268356 |
| SP100 | SP100 nuclear antigen | 0.0262742 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0261431 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0261154 |
| ITGA10 | integrin, alpha 10 | 0.0256462 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0255855 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0255589 |
| NAV2 | neuron navigator 2 | 0.0254517 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0252931 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0248734 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0248383 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.024751 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.024668 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.024665 |
| BMP2K | BMP2 inducible kinase | 0.0246088 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0241839 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | 0.0240446 |
| RPL7A | ribosomal protein L7a | 0.0240353 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0240168 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0237424 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0237036 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.023701 |
| MACROD2 | MACRO domain containing 2 | 0.0236739 |
| MYOF | myoferlin | 0.0236596 |
| ZNF638 | zinc finger protein 638 | 0.0233797 |
| SON | SON DNA binding protein | 0.0233794 |
| EFNA5 | ephrin-A5 | 0.0233623 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0233239 |
| CENPF | centromere protein F, 350/400kDa | 0.023226 |
| PKP4 | plakophilin 4 | 0.0231771 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0231475 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.213211 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.138681 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.112162 |
| ZNF292 | zinc finger protein 292 | -0.0853972 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0772398 |
| PTMA | prothymosin, alpha | -0.0704973 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0659494 |
| S100A6 | S100 calcium binding protein A6 | -0.0603777 |
| GOLGA4 | golgin A4 | -0.0575226 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0524569 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.051595 |
| TMSB4X | thymosin beta 4, X-linked | -0.0475228 |
| TFG | TRK-fused gene | -0.0447134 |
| RPL35A | ribosomal protein L35a | -0.0445166 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0432225 |
| CDC73 | cell division cycle 73 | -0.0426365 |
| RBM39 | RNA binding motif protein 39 | -0.0419131 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0401858 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0383972 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0366259 |
| RNF145 | ring finger protein 145 | -0.0365847 |
| QKI | QKI, KH domain containing, RNA binding | -0.0365788 |
| RPL13A | ribosomal protein L13a | -0.0343048 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.033681 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.033122 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0330914 |
| PFN1 | profilin 1 | -0.0326638 |
| LDHA | lactate dehydrogenase A | -0.0324294 |
| GNAS | GNAS complex locus | -0.0315623 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0313765 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0312075 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0309165 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0295253 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0294855 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0294469 |
| NOP58 | NOP58 ribonucleoprotein | -0.0293845 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0291812 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0288028 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0286809 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0282581 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0281978 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0281346 |
| SRP54 | signal recognition particle 54kDa | -0.028033 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.026894 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0267951 |
| OGA | O-GlcNAcase | -0.0266889 |
| NUP58 | nucleoporin 58 | -0.0265362 |
| COG5 | component of oligomeric golgi complex 5 | -0.0264367 |
| ACTG1 | actin gamma 1 | -0.0261337 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0260597 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0253312 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0249309 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0247124 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0241169 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0241128 |
| COPA | coatomer protein complex, subunit alpha | -0.0237597 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0237362 |
| CASC3 | cancer susceptibility candidate 3 | -0.0237219 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0236279 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0235443 |
| ANK2 | ankyrin 2, neuronal | -0.0234159 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0232196 |
| XPO1 | exportin 1 | -0.0230684 |
| RLF | rearranged L-myc fusion | -0.0229541 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0228664 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0228193 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.022653 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0225487 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0224361 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0223183 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0221022 |
| PHIP | pleckstrin homology domain interacting protein | -0.0220232 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0219585 |
| CANX | calnexin | -0.0218705 |
| RPL34 | ribosomal protein L34 | -0.0218377 |
| MATR3 | matrin 3 | -0.0215696 |
| PREPL | prolyl endopeptidase-like | -0.0214492 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0213846 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0213646 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0213569 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0212905 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0212049 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0210825 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0210348 |
| NEMF | nuclear export mediator factor | -0.0210147 |
| CCNL1 | cyclin L1 | -0.0209477 |
| RAD21 | RAD21 homolog (S. pombe) | -0.020926 |
| UBP1 | upstream binding protein 1 (LBP-1a) | -0.0208975 |
| FAM13A | family with sequence similarity 13, member A | -0.020849 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0208457 |
| RARS1 | arginyl-tRNA synthetase 1 | -0.0207337 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0207335 |
| USP15 | ubiquitin specific peptidase 15 | -0.0205941 |
| TXNIP | thioredoxin interacting protein | -0.0205484 |
| SEC63 | SEC63 homolog (S. cerevisiae) | -0.0204793 |
| RPLP1 | ribosomal protein, large, P1 | -0.0202198 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0201326 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0201001 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0197403 |
| SESN2 | sestrin 2 | -0.0197351 |
