| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.16262 |
| HDAC9 | histone deacetylase 9 | 0.11193 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0914673 |
| VEGFA | vascular endothelial growth factor A | 0.0811267 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0722913 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0713928 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0703544 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0692703 |
| LDHA | lactate dehydrogenase A | 0.0687469 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0683303 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0666941 |
| NAV2 | neuron navigator 2 | 0.0660608 |
| MSN | moesin | 0.0659789 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.056806 |
| JMJD1C | jumonji domain containing 1C | 0.0544384 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0535654 |
| RND3 | Rho family GTPase 3 | 0.0527695 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0504418 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0443576 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0429844 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0423628 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0419012 |
| ATXN1 | ataxin 1 | 0.0409134 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0407411 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0399249 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0375606 |
| C3 | complement component 3 | 0.0369832 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0368894 |
| MYOF | myoferlin | 0.0367689 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0354678 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0347254 |
| CD44 | CD44 molecule (Indian blood group) | 0.0341012 |
| KYNU | kynureninase | 0.0337525 |
| B2M | beta-2-microglobulin | 0.0331416 |
| PDE10A | phosphodiesterase 10A | 0.032493 |
| ARRDC3 | arrestin domain containing 3 | 0.0319858 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0316255 |
| FNIP1 | folliculin interacting protein 1 | 0.0313965 |
| PKM | pyruvate kinase, muscle | 0.0305894 |
| BRD2 | bromodomain containing 2 | 0.0297619 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0297448 |
| VMP1 | vacuole membrane protein 1 | 0.0288987 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0285688 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0284085 |
| TNS3 | tensin 3 | 0.0282043 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0281219 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0276779 |
| SYNJ2 | synaptojanin 2 | 0.0274424 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0268554 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0267686 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0267119 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0266464 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.026566 |
| DST | dystonin | 0.0263583 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0261031 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0260606 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0259946 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0258042 |
| EGFR | epidermal growth factor receptor | 0.0257476 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0256995 |
| GOLGB1 | golgin B1 | 0.0253852 |
| LOXL2 | lysyl oxidase-like 2 | 0.0253124 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0252053 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.025028 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0249191 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0248103 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0246954 |
| MMP12 | matrix metallopeptidase 12 | 0.0245832 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0244818 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0244807 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0240213 |
| USP47 | ubiquitin specific peptidase 47 | 0.0237182 |
| PTEN | phosphatase and tensin homolog | 0.0235066 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0232245 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0231482 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0231241 |
| PRKCE | protein kinase C, epsilon | 0.0229841 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0228175 |
| ANO6 | anoctamin 6 | 0.0226964 |
| CADM1 | cell adhesion molecule 1 | 0.0225793 |
| RUNX1 | runt-related transcription factor 1 | 0.0224578 |
| DSTN | destrin (actin depolymerizing factor) | 0.022316 |
| PGM3 | phosphoglucomutase 3 | 0.0222887 |
| MCL1 | myeloid cell leukemia 1 | 0.0222032 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0220734 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.021768 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0214124 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0212952 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0212727 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0211055 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0211045 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | 0.020985 |
| GOLGA4 | golgin A4 | 0.0208985 |
| INTS6 | integrator complex subunit 6 | 0.0208747 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0208313 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0207742 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0205749 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0205514 |
| ADM | adrenomedullin | 0.0203657 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.020338 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.154746 |
| IER3 | immediate early response 3 | -0.105494 |
| GLIS3 | GLIS family zinc finger 3 | -0.0775984 |
| TMSB10 | thymosin beta 10 | -0.0764201 |
| VIM | vimentin | -0.0762273 |
| HLA-B | major histocompatibility complex, class I, B | -0.0741609 |
| PTMA | prothymosin, alpha | -0.0705668 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0608387 |
| COL1A1 | collagen, type I, alpha 1 | -0.0607156 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0596481 |
| RPS24 | ribosomal protein S24 | -0.0576016 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0565831 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0561851 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.055765 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0547398 |
| FN1 | fibronectin 1 | -0.0542576 |
| RPL35A | ribosomal protein L35a | -0.0535051 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0521695 |
| FTL | ferritin, light polypeptide | -0.0515378 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.049649 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.048341 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0474518 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0474457 |
| GNAS | GNAS complex locus | -0.0466567 |
| CAVIN1 | caveolae associated protein 1 | -0.0465837 |
| ACTG1 | actin gamma 1 | -0.0424498 |
| OGA | O-GlcNAcase | -0.0417929 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0416241 |
| TUBB | tubulin, beta class I | -0.0400635 |
| VCL | vinculin | -0.0398934 |
| FRMD4A | FERM domain containing 4A | -0.0395269 |
| TMSB4X | thymosin beta 4, X-linked | -0.0390945 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0384931 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0378575 |
| NRN1 | neuritin 1 | -0.0372086 |
| PGK1 | phosphoglycerate kinase 1 | -0.0369961 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.036486 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0364581 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0363028 |
| AHNAK | AHNAK nucleoprotein | -0.0343393 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0336586 |
| CUL4B | cullin 4B | -0.0321181 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0315159 |
| RPLP1 | ribosomal protein, large, P1 | -0.0311931 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0304946 |
| FAM20C | family with sequence similarity 20, member C | -0.0300414 |
| RPS27A | ribosomal protein S27a | -0.0299032 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0298538 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.029815 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0295087 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0286922 |
| BICC1 | BicC family RNA binding protein 1 | -0.0285422 |
| RPL38 | ribosomal protein L38 | -0.0285366 |
| THBS2 | thrombospondin 2 | -0.0282023 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0281029 |
| RPS21 | ribosomal protein S21 | -0.0270488 |
| RPL26 | ribosomal protein L26 | -0.0270315 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0264899 |
| COL1A2 | collagen, type I, alpha 2 | -0.0264883 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0257375 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.025715 |
| SDC4 | syndecan 4 | -0.0256868 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0256649 |
| ANXA2 | annexin A2 | -0.02565 |
| RTN4 | reticulon 4 | -0.0253245 |
| CD2AP | CD2-associated protein | -0.0246401 |
| KLF6 | Kruppel-like factor 6 | -0.0245752 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0245047 |
| RRBP1 | ribosome binding protein 1 | -0.0243009 |
| THBS1 | thrombospondin 1 | -0.0242357 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0240363 |
| CTSD | cathepsin D | -0.0239608 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0239164 |
| TMEM123 | transmembrane protein 123 | -0.0237988 |
| SRGN | serglycin | -0.0236785 |
| RPS4X | ribosomal protein S4, X-linked | -0.0234632 |
| TMEM263 | transmembrane protein 263 | -0.0234212 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0233971 |
| TPM4 | tropomyosin 4 | -0.0232039 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.023009 |
| CANX | calnexin | -0.0229804 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0227801 |
| RAI14 | retinoic acid induced 14 | -0.0226926 |
| RPL34 | ribosomal protein L34 | -0.0224937 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -0.0212589 |
| RPL12 | ribosomal protein L12 | -0.021242 |
| NPR2 | natriuretic peptide receptor 2 | -0.021205 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0211542 |
| SEPTIN7 | septin 7 | -0.0211492 |
| RBM39 | RNA binding motif protein 39 | -0.0207406 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0207009 |
| RPL36A | ribosomal protein L36a | -0.0205335 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0204805 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0204455 |
| HMGA2 | high mobility group AT-hook 2 | -0.0204138 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0204122 |
| HDLBP | high density lipoprotein binding protein | -0.0199369 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0195034 |
| RPS3 | ribosomal protein S3 | -0.0194033 |
| CCDC47 | coiled-coil domain containing 47 | -0.0193718 |
