LY-2584702 (tosylate salt)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY-2584702 (tosylate salt) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY-2584702 (tosylate salt)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.1501
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.122595
FN1 fibronectin 1 0.110787
TGFBI transforming growth factor, beta-induced, 68kDa 0.0874684
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0862295
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0849014
HLA-B major histocompatibility complex, class I, B 0.0747579
COL6A3 collagen, type VI, alpha 3 0.0663873
TIMP3 TIMP metallopeptidase inhibitor 3 0.0656304
TPT1 tumor protein, translationally-controlled 1 0.0607552
CALU calumenin 0.0573539
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0552142
RPLP2 ribosomal protein, large, P2 0.0539445
VIM vimentin 0.0487465
ERRFI1 ERBB receptor feedback inhibitor 1 0.0482847
CALR calreticulin 0.045374
PRSS23 protease, serine, 23 0.0453205
RPS3 ribosomal protein S3 0.0415113
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0403861
RPS13 ribosomal protein S13 0.0391254
GOLGB1 golgin B1 0.0389637
TMSB10 thymosin beta 10 0.038583
FNDC3B fibronectin type III domain containing 3B 0.0381896
RPL19 ribosomal protein L19 0.0361111
MT2A metallothionein 2A 0.0354506
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0352562
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.034787
COL5A1 collagen, type V, alpha 1 0.0340456
RPS19 ribosomal protein S19 0.0339494
RPS8 ribosomal protein S8 0.0337071
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0333171
AHNAK AHNAK nucleoprotein 0.0325911
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0321608
ZSWIM6 zinc finger, SWIM-type containing 6 0.0311915
RPS12 ribosomal protein S12 0.0310235
SLC38A2 solute carrier family 38, member 2 0.0305055
WSB1 WD repeat and SOCS box containing 1 0.0303222
RPL37 ribosomal protein L37 0.0302794
PGK1 phosphoglycerate kinase 1 0.0300205
ANXA2 annexin A2 0.0295863
PTMA prothymosin, alpha 0.0292354
RPS14 ribosomal protein S14 0.0291018
ACTG1 actin gamma 1 0.0289623
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0283973
RPL37A ribosomal protein L37a 0.0282912
CANX calnexin 0.0281376
MTPN myotrophin 0.0277542
PDE4D phosphodiesterase 4D, cAMP-specific 0.0277019
FTL ferritin, light polypeptide 0.0275223
RPS29 ribosomal protein S29 0.0270367
ASPH aspartate beta-hydroxylase 0.0270249
TRIO trio Rho guanine nucleotide exchange factor 0.0269385
ZBTB20 zinc finger and BTB domain containing 20 0.0268251
B2M beta-2-microglobulin 0.0267335
RPL31 ribosomal protein L31 0.0264133
RPL35A ribosomal protein L35a 0.026024
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0258775
RRBP1 ribosome binding protein 1 0.0252984
CXCL8 chemokine (C-X-C motif) ligand 8 0.0252384
RPL15 ribosomal protein L15 0.024931
RAB1A RAB1A, member RAS oncogene family 0.0247858
WARS1 tryptophanyl-tRNA synthetase 1 0.0247544
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0240764
EXOC4 exocyst complex component 4 0.0239754
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0237083
COL1A1 collagen, type I, alpha 1 0.0237058
RPL36A ribosomal protein L36a 0.0236904
ANKRD11 ankyrin repeat domain 11 0.023684
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0236196
RAB7A RAB7A, member RAS oncogene family 0.0233674
TRIM56 tripartite motif containing 56 0.0232935
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.023167
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0231373
RPL9 ribosomal protein L9 0.0230809
SKAP2 src kinase associated phosphoprotein 2 0.0229691
COL6A1 collagen, type VI, alpha 1 0.0227002
PDIA4 protein disulfide isomerase family A, member 4 0.0226717
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0226414
SEC24D SEC24 family member D 0.0220738
GLG1 golgi glycoprotein 1 0.0219296
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0219064
ACTN1 actinin, alpha 1 0.0217547
ZCCHC7 zinc finger, CCHC domain containing 7 0.0216817
LDHA lactate dehydrogenase A 0.0215269
PTK2 protein tyrosine kinase 2 0.0214737
APLP2 amyloid beta (A4) precursor-like protein 2 0.0214406
UBC ubiquitin C 0.0213539
LPP LIM domain containing preferred translocation partner in lipoma 0.0213125
RPS23 ribosomal protein S23 0.0212215
SET SET nuclear proto-oncogene 0.0211787
HM13 histocompatibility (minor) 13 0.0211109
SQSTM1 sequestosome 1 0.0210298
GSE1 Gse1 coiled-coil protein 0.020473
MYH9 myosin, heavy chain 9, non-muscle 0.0202922
MSN moesin 0.0200583
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0199393
RPS25 ribosomal protein S25 0.0197754
FBXL7 F-box and leucine-rich repeat protein 7 0.0197209
RPL23 ribosomal protein L23 0.0194092
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.019336

decreased expression

Symbol Name Standardized Value
PDIA3 protein disulfide isomerase family A, member 3 -0.0297826
UGCG UDP-glucose ceramide glucosyltransferase -0.0290574
ZNF292 zinc finger protein 292 -0.0266602
MATR3 matrin 3 -0.0266329
RBM39 RNA binding motif protein 39 -0.026206
QKI QKI, KH domain containing, RNA binding -0.0253746
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0251047
HIP1 huntingtin interacting protein 1 -0.0244282
PRRC2C proline-rich coiled-coil 2C -0.0234597
WAC WW domain containing adaptor with coiled-coil -0.0232753
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0232248
TRA2A transformer 2 alpha homolog (Drosophila) -0.0230917
ADAM9 ADAM metallopeptidase domain 9 -0.0219123
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0216214
CCNL1 cyclin L1 -0.0211187
WDR45B WD repeat domain 45B -0.0196795
INSIG2 insulin induced gene 2 -0.0188195
NAMPT nicotinamide phosphoribosyltransferase -0.0184536
MEF2A myocyte enhancer factor 2A -0.0183862
FTH1 ferritin, heavy polypeptide 1 -0.0183243
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0182365
TFG TRK-fused gene -0.0181352
ADM adrenomedullin -0.0180803
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.017892
DLG1 discs, large homolog 1 (Drosophila) -0.0177647
CD109 CD109 molecule -0.0175588
COL1A2 collagen, type I, alpha 2 -0.017097
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0170589
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0167596
PRRC1 proline-rich coiled-coil 1 -0.0165711
COG6 component of oligomeric golgi complex 6 -0.0164108
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0162731
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0161099
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0161015
SDC4 syndecan 4 -0.0156783
AKAP10 A kinase (PRKA) anchor protein 10 -0.0155806
TAGLN2 transgelin 2 -0.0154563
RAB8B RAB8B, member RAS oncogene family -0.0153239
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0152374
GPBP1 GC-rich promoter binding protein 1 -0.0151559
NEK7 NIMA-related kinase 7 -0.0150292
WASHC4 WASH complex subunit 4 -0.0149748
ATP13A3 ATPase type 13A3 -0.0148246
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0145689
FOSL1 FOS-like antigen 1 -0.0143772
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0143031
FAM13A family with sequence similarity 13, member A -0.0142582
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0142082
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0140863
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0140347
NRG1 neuregulin 1 -0.014027
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.0139856
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.013928
NGLY1 N-glycanase 1 -0.0139096
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0139044
PI3 peptidase inhibitor 3, skin-derived -0.0138611
EGR1 early growth response 1 -0.0138356
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0137839
ESYT2 extended synaptotagmin-like protein 2 -0.0136658
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0135279
SOCS5 suppressor of cytokine signaling 5 -0.0135126
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0135079
SEC62 SEC62 homolog (S. cerevisiae) -0.0134877
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0133245
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0132942
RBM27 RNA binding motif protein 27 -0.013198
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0131283
NPEPPS aminopeptidase puromycin sensitive -0.0130342
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0128616
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0127994
RNF11 ring finger protein 11 -0.0127162
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0126955
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0126467
CARD16 caspase recruitment domain family, member 16 -0.0125801
TCF12 transcription factor 12 -0.0125354
CADM1 cell adhesion molecule 1 -0.0125197
INHBA inhibin, beta A -0.0125176
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0124946
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.012488
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0123376
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0123304
RBM5 RNA binding motif protein 5 -0.012301
PFKL phosphofructokinase, liver -0.0122485
C1ORF21 chromosome 1 open reading frame 21 -0.0122205
VEGFA vascular endothelial growth factor A -0.0120783
TRA2B transformer 2 beta homolog (Drosophila) -0.0120102
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0120053
PTBP3 polypyrimidine tract binding protein 3 -0.0119804
NUMB numb homolog (Drosophila) -0.0119794
FBXO11 F-box protein 11 -0.0118785
CDK17 cyclin-dependent kinase 17 -0.0118269
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0118019
CIRSR corepressor of RBPJ and splicing regulator -0.0117945
RAI14 retinoic acid induced 14 -0.011787
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0117776
NCKAP1 NCK-associated protein 1 -0.0117637
S100A6 S100 calcium binding protein A6 -0.0117555
PDE10A phosphodiesterase 10A -0.011711
USP12 ubiquitin specific peptidase 12 -0.0116197
ARRDC3 arrestin domain containing 3 -0.0116139