| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY-2584702 (tosylate salt)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.147487 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.14647 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.112501 |
| PTMA | prothymosin, alpha | 0.103099 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0997557 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0974648 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0853612 |
| LDHA | lactate dehydrogenase A | 0.0812321 |
| PGK1 | phosphoglycerate kinase 1 | 0.0811014 |
| RPS6 | ribosomal protein S6 | 0.0795084 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.076652 |
| ENO1 | enolase 1, (alpha) | 0.0756381 |
| EZR | ezrin | 0.071431 |
| ITGA6 | integrin, alpha 6 | 0.0695515 |
| KRT18 | keratin 18, type I | 0.0642806 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0640802 |
| VIM | vimentin | 0.0604255 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0551391 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0549644 |
| GOLGA4 | golgin A4 | 0.0548996 |
| ANXA2 | annexin A2 | 0.0543225 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0509389 |
| TMSB4X | thymosin beta 4, X-linked | 0.0498844 |
| DSPP | dentin sialophosphoprotein | 0.0498251 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0494528 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0456366 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0446437 |
| SNX9 | sorting nexin 9 | 0.0441815 |
| TPM4 | tropomyosin 4 | 0.0435336 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0410064 |
| RPLP0 | ribosomal protein, large, P0 | 0.040764 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0400892 |
| ZNF292 | zinc finger protein 292 | 0.0389878 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0387051 |
| YBX1 | Y box binding protein 1 | 0.0384279 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0383277 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0380609 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0378265 |
| RPS8 | ribosomal protein S8 | 0.0378242 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0370986 |
| JMJD1C | jumonji domain containing 1C | 0.0370827 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0369594 |
| S100A6 | S100 calcium binding protein A6 | 0.0368531 |
| KRT8 | keratin 8, type II | 0.0363627 |
| TXNIP | thioredoxin interacting protein | 0.0361666 |
| EMP1 | epithelial membrane protein 1 | 0.0360692 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0356596 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0355591 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0351861 |
| SET | SET nuclear proto-oncogene | 0.0350986 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0348686 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.03408 |
| XPO1 | exportin 1 | 0.0339788 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0337804 |
| H3-3B | H3.3 histone B | 0.0336856 |
| RPL39 | ribosomal protein L39 | 0.0332869 |
| PERP | PERP, TP53 apoptosis effector | 0.0330642 |
| UBC | ubiquitin C | 0.0329491 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0326459 |
| TMEM123 | transmembrane protein 123 | 0.0325968 |
| RPL35A | ribosomal protein L35a | 0.0325423 |
| RACK1 | receptor for activated C kinase 1 | 0.0321924 |
| TPI1 | triosephosphate isomerase 1 | 0.032102 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0320184 |
| RPLP1 | ribosomal protein, large, P1 | 0.0316327 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0309198 |
| DEK | DEK proto-oncogene | 0.030865 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0306764 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0304413 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0303118 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0300759 |
| PKM | pyruvate kinase, muscle | 0.0300251 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0300189 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0299039 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | 0.029877 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0298575 |
| ARHGAP18 | Rho GTPase activating protein 18 | 0.0296923 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0295655 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0295264 |
| CANX | calnexin | 0.0294639 |
| RPL7 | ribosomal protein L7 | 0.0293381 |
| CBX3 | chromobox homolog 3 | 0.0291079 |
| IPO7 | importin 7 | 0.0290898 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0289486 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0288811 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0285551 |
| MKI67 | marker of proliferation Ki-67 | 0.0283851 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0283522 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0282004 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.028101 |
| MED13 | mediator complex subunit 13 | 0.0280695 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.02786 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0278277 |
| RPS2 | ribosomal protein S2 | 0.0277252 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0273895 |
| RPL30 | ribosomal protein L30 | 0.0273653 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0273049 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0272863 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0272073 |
| SPATA13 | spermatogenesis associated 13 | 0.0271611 |
| Symbol | Name | Standardized Value |
|---|---|---|
| INTS6 | integrator complex subunit 6 | -0.09931 |
| RPL37A | ribosomal protein L37a | -0.0531662 |
| RPS19 | ribosomal protein S19 | -0.0494856 |
| RPS29 | ribosomal protein S29 | -0.0471708 |
| NAV2 | neuron navigator 2 | -0.0455332 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0418339 |
| VCL | vinculin | -0.041816 |
| RPL31 | ribosomal protein L31 | -0.0387717 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0372783 |
| HDAC4 | histone deacetylase 4 | -0.0347891 |
| RPS25 | ribosomal protein S25 | -0.0338658 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0321875 |
| RPL36 | ribosomal protein L36 | -0.0320898 |
| MT2A | metallothionein 2A | -0.0306563 |
| RPL28 | ribosomal protein L28 | -0.0291132 |
| RPLP2 | ribosomal protein, large, P2 | -0.0286319 |
| CDH13 | cadherin 13 | -0.0283673 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0251381 |
| EXOC4 | exocyst complex component 4 | -0.024457 |
| RPS23 | ribosomal protein S23 | -0.0230918 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0229774 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0224488 |
| NABP1 | nucleic acid binding protein 1 | -0.0220677 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0218964 |
| RAD51B | RAD51 paralog B | -0.0217808 |
| RPS11 | ribosomal protein S11 | -0.0216163 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0210884 |
| RPS15 | ribosomal protein S15 | -0.0209845 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0189504 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0185557 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0184707 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.018125 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.0180354 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0176662 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0172586 |
| RPS21 | ribosomal protein S21 | -0.0169368 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0168409 |
| RCC1 | regulator of chromosome condensation 1 | -0.0165941 |
| RPL38 | ribosomal protein L38 | -0.0163665 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0162182 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0160713 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0158861 |
| CDK13 | cyclin-dependent kinase 13 | -0.0157471 |
| CSTF3 | cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa | -0.0156494 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0154996 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0154216 |
| RPS27A | ribosomal protein S27a | -0.0152709 |
| FLNA | filamin A, alpha | -0.0149074 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | -0.014604 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.0146031 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0145275 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0145086 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0144256 |
| NOP56 | NOP56 ribonucleoprotein | -0.0143736 |
| AEBP2 | AE binding protein 2 | -0.0143407 |
| RPS12 | ribosomal protein S12 | -0.0136928 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | -0.0136589 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.0134196 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0129337 |
| E2F3 | E2F transcription factor 3 | -0.0129173 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0127042 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.01264 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0126209 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0123413 |
| HLA-B | major histocompatibility complex, class I, B | -0.0123253 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0122416 |
| FHIT | fragile histidine triad | -0.0121364 |
| MCL1 | myeloid cell leukemia 1 | -0.0119569 |
| DIAPH3 | diaphanous-related formin 3 | -0.0119392 |
| LAMA5 | laminin, alpha 5 | -0.0119069 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0115721 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0115641 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0114282 |
| ZNF75D | zinc finger protein 75D | -0.0112385 |
| FLNB | filamin B, beta | -0.0112136 |
| RPL9 | ribosomal protein L9 | -0.0111676 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0110857 |
| ANKMY1 | ankyrin repeat and MYND domain containing 1 | -0.0110549 |
| DHFR | dihydrofolate reductase | -0.0110155 |
| FNDC3B | fibronectin type III domain containing 3B | -0.010988 |
| SRSF6 | serine/arginine-rich splicing factor 6 | -0.0109586 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | -0.0108618 |
| VKORC1L1 | vitamin K epoxide reductase complex, subunit 1-like 1 | -0.0108118 |
| RPS17 | ribosomal protein S17 | -0.0107747 |
| EGFR | epidermal growth factor receptor | -0.0107691 |
| METTL15 | methyltransferase like 15 | -0.0107339 |
| WDR27 | WD repeat domain 27 | -0.0104999 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0104461 |
| POU2F1 | POU class 2 homeobox 1 | -0.0104082 |
| TRRAP | transformation/transcription domain-associated protein | -0.0103439 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0103337 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0102626 |
| PDE10A | phosphodiesterase 10A | -0.0102434 |
| R3HDM2 | R3H domain containing 2 | -0.010224 |
| RPL36A | ribosomal protein L36a | -0.0101983 |
| HMGA2 | high mobility group AT-hook 2 | -0.0101186 |
| GLCCI1 | glucocorticoid induced 1 | -0.0100565 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.0100255 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.00998763 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.009947 |
