| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY-2584702 (tosylate salt) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY-2584702 (tosylate salt)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.323399 |
| HMGA2 | high mobility group AT-hook 2 | 0.186853 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.168216 |
| INHBA | inhibin, beta A | 0.132757 |
| HLA-B | major histocompatibility complex, class I, B | 0.126865 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.111748 |
| VIM | vimentin | 0.110414 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.10841 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.102282 |
| STC1 | stanniocalcin 1 | 0.0897579 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0878766 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0850406 |
| FBN1 | fibrillin 1 | 0.0774396 |
| LOX | lysyl oxidase | 0.0762861 |
| B2M | beta-2-microglobulin | 0.0762401 |
| MMP1 | matrix metallopeptidase 1 | 0.0682928 |
| CALR | calreticulin | 0.0674487 |
| CD44 | CD44 molecule (Indian blood group) | 0.065381 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0640818 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0639066 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.062612 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0625206 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0602173 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0597742 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.059511 |
| HDLBP | high density lipoprotein binding protein | 0.0592346 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0568966 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0550606 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.0540796 |
| MMP12 | matrix metallopeptidase 12 | 0.0526904 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0516318 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0510397 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0499074 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0486905 |
| HLA-E | major histocompatibility complex, class I, E | 0.0479406 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.047397 |
| NAV1 | neuron navigator 1 | 0.0473296 |
| CAVIN1 | caveolae associated protein 1 | 0.0452988 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0447858 |
| DST | dystonin | 0.0447359 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0441155 |
| INTS6 | integrator complex subunit 6 | 0.0439898 |
| DNER | delta/notch-like EGF repeat containing | 0.0422757 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0409652 |
| RPS8 | ribosomal protein S8 | 0.040673 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0386676 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0385953 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0380264 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0377741 |
| HDAC9 | histone deacetylase 9 | 0.0371032 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0370281 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0359246 |
| LDHA | lactate dehydrogenase A | 0.0356747 |
| NBEAL1 | neurobeachin-like 1 | 0.0354671 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0353494 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0347635 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0347441 |
| GOLGB1 | golgin B1 | 0.0344372 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0343182 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0340272 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0339764 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0331455 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0328182 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.032658 |
| FAM114A1 | family with sequence similarity 114, member A1 | 0.0323951 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0314034 |
| ATM | ATM serine/threonine kinase | 0.0313188 |
| ENO1 | enolase 1, (alpha) | 0.0311495 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0311156 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0311004 |
| CA12 | carbonic anhydrase XII | 0.0309021 |
| DOCK5 | dedicator of cytokinesis 5 | 0.030779 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0307545 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0306474 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0302879 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0302605 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0299506 |
| NPTX1 | neuronal pentraxin I | 0.0298043 |
| IGF2 | insulin-like growth factor 2 | 0.0291338 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0290017 |
| TMEM165 | transmembrane protein 165 | 0.0289945 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0287323 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0281378 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.02737 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0271697 |
| RPL7A | ribosomal protein L7a | 0.027081 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0270432 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0267979 |
| SEC24D | SEC24 family member D | 0.0265577 |
| AEBP2 | AE binding protein 2 | 0.0265156 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0264993 |
| FNIP1 | folliculin interacting protein 1 | 0.0262373 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0258724 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.0255497 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0255381 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0252091 |
| PALLD | palladin, cytoskeletal associated protein | 0.0251939 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0249135 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0246929 |
| FSTL1 | follistatin-like 1 | 0.0238238 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0861051 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0818082 |
| FAM13A | family with sequence similarity 13, member A | -0.0685981 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0632938 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.060062 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0591204 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0502478 |
| POTEF | POTE ankyrin domain family, member F | -0.0483591 |
| RNF145 | ring finger protein 145 | -0.0479065 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0460561 |
| RPLP1 | ribosomal protein, large, P1 | -0.0457918 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.044804 |
| COL1A2 | collagen, type I, alpha 2 | -0.0429604 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0393292 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0377351 |
| ZNF292 | zinc finger protein 292 | -0.0366024 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0363232 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0358967 |
| RTN4 | reticulon 4 | -0.0350593 |
| PFN1 | profilin 1 | -0.0345826 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0325059 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0320335 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0319076 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0307277 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0292978 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0291065 |
| USP3 | ubiquitin specific peptidase 3 | -0.0280866 |
| RPS6 | ribosomal protein S6 | -0.0276072 |
| RPL34 | ribosomal protein L34 | -0.0267905 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.026731 |
| RPL35A | ribosomal protein L35a | -0.0257782 |
| PER1 | period circadian clock 1 | -0.0251673 |
| TMSB10 | thymosin beta 10 | -0.0247552 |
| SEPTIN11 | septin 11 | -0.0244922 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.024287 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0241206 |
| SPAG9 | sperm associated antigen 9 | -0.0240098 |
| YBX1 | Y box binding protein 1 | -0.0238728 |
| MATR3 | matrin 3 | -0.0230417 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0228898 |
| IER3 | immediate early response 3 | -0.0224136 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0219897 |
| S100A6 | S100 calcium binding protein A6 | -0.021871 |
| CENPF | centromere protein F, 350/400kDa | -0.0216528 |
| RYBP | RING1 and YY1 binding protein | -0.0216195 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0214949 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0213173 |
| CALD1 | caldesmon 1 | -0.0211349 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0209492 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0208535 |
| HELZ | helicase with zinc finger | -0.0204477 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0203214 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.020306 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0203005 |
| CDK17 | cyclin-dependent kinase 17 | -0.0202391 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0202293 |
| NEK7 | NIMA-related kinase 7 | -0.0199674 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0199385 |
| QKI | QKI, KH domain containing, RNA binding | -0.0197066 |
| OXR1 | oxidation resistance 1 | -0.0197042 |
| PRR16 | proline rich 16 | -0.0195841 |
| ARRDC3 | arrestin domain containing 3 | -0.0195296 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0194685 |
| PLPP3 | phospholipid phosphatase 3 | -0.0188513 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0188305 |
| MYOF | myoferlin | -0.0188288 |
| RNF24 | ring finger protein 24 | -0.0186623 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0186239 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0183385 |
| PHIP | pleckstrin homology domain interacting protein | -0.0183224 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.018255 |
| SNX9 | sorting nexin 9 | -0.0181225 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0181213 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0180791 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0180277 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0179918 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0179542 |
| PCBP2 | poly(rC) binding protein 2 | -0.0178266 |
| CUL3 | cullin 3 | -0.0177838 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0177472 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0175982 |
| HMGB2 | high mobility group box 2 | -0.0173833 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0172489 |
| TFG | TRK-fused gene | -0.0172055 |
| PTK2 | protein tyrosine kinase 2 | -0.0171961 |
| TPM3 | tropomyosin 3 | -0.0171903 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0170823 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0169381 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0166551 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0165481 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0164317 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0163374 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.0161894 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0159032 |
| ATP11B | ATPase, class VI, type 11B | -0.0158301 |
| ANXA5 | annexin A5 | -0.0157087 |
| RPS2 | ribosomal protein S2 | -0.0156343 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0156027 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0155356 |
| HMGB1 | high mobility group box 1 | -0.0154963 |
