LY-294002-429 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the LY-294002-429 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGER advanced glycosylation end product-specific receptor
AHR aryl hydrocarbon receptor
AKAP9 A kinase (PRKA) anchor protein 9
ANAPC2 anaphase promoting complex subunit 2
ANKRD36B ankyrin repeat domain 36B
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATXN1 ataxin 1
AXIN1 axin 1
BCL6 B-cell CLL/lymphoma 6
C20ORF27 chromosome 20 open reading frame 27
C2CD2L C2CD2-like
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COL5A3 collagen, type V, alpha 3
CPE carboxypeptidase E
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DPP4 dipeptidyl-peptidase 4
DST dystonin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ESR2 estrogen receptor 2 (ER beta)
EXOC6B exocyst complex component 6B
FGD6 FYVE, RhoGEF and PH domain containing 6
FRMD1 FERM domain containing 1
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAS7 growth arrest-specific 7
GAS8 growth arrest-specific 8
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GIMAP5 GTPase, IMAP family member 5
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GM2A GM2 ganglioside activator
GPR107 G protein-coupled receptor 107
H2AFY2 H2A histone family, member Y2
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HIST1H3E histone cluster 1, H3e
HIST1H3G histone cluster 1, H3g
HOMER1 homer scaffolding protein 1
HOXA9 homeobox A9
HP1BP3 heterochromatin protein 1, binding protein 3
HUS1 HUS1 checkpoint homolog (S. pombe)
IFFO1 intermediate filament family orphan 1
IFI35 interferon-induced protein 35
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
INTS6 integrator complex subunit 6
ITGB5 integrin, beta 5
KCTD12 potassium channel tetramerization domain containing 12
KHNYN KH and NYN domain containing
KLHL20 kelch-like family member 20
KLHL24 kelch-like family member 24
L1CAM L1 cell adhesion molecule
LHX3 LIM homeobox 3
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MTERF4 mitochondrial transcription termination factor 4
MXD4 MAX dimerization protein 4
MYCBP MYC binding protein
MYT1 myelin transcription factor 1
MZF1 myeloid zinc finger 1
NCOA3 nuclear receptor coactivator 3
NPAT nuclear protein, ataxia-telangiectasia locus
OLFML2A olfactomedin-like 2A
PAIP2B poly(A) binding protein interacting protein 2B
PARVA parvin, alpha
PC pyruvate carboxylase
PCBP2 poly(rC) binding protein 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLK3 polo-like kinase 3
POGZ pogo transposable element with ZNF domain
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTPRM protein tyrosine phosphatase, receptor type, M
RAD54L RAD54-like (S. cerevisiae)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RBM48 RNA binding motif protein 48
RNF185 ring finger protein 185
RPL10 ribosomal protein L10
RPS2 ribosomal protein S2
RUNX1 runt-related transcription factor 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
STXBP5L syntaxin binding protein 5-like
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TKFC triokinase/FMN cyclase
TMEM176A transmembrane protein 176A
TMEM47 transmembrane protein 47
TMPRSS5 transmembrane protease, serine 5
TNNT1 troponin T type 1 (skeletal, slow)
TRIM58 tripartite motif containing 58
TUBA4B tubulin, alpha 4b
TULP3 tubby like protein 3
WSB1 WD repeat and SOCS box containing 1
YPEL1 yippee-like 1 (Drosophila)
ZBTB25 zinc finger and BTB domain containing 25
ZER1 zyg-11 related, cell cycle regulator
ZNF136 zinc finger protein 136

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARR3 arrestin 3, retinal (X-arrestin)
ATF1 activating transcription factor 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCAS4 breast carcinoma amplified sequence 4
BLMH bleomycin hydrolase
C11ORF48
C11ORF71 chromosome 11 open reading frame 71
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK6 cyclin-dependent kinase 6
CDR2L cerebellar degeneration-related protein 2-like
CHKB choline kinase beta
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCA1 chloride channel accessory 1
CUEDC1 CUE domain containing 1
CUTC cutC copper transporter
DPH2 DPH2 homolog (S. cerevisiae)
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EMC9 ER membrane protein complex subunit 9
ERN2 endoplasmic reticulum to nucleus signaling 2
EVPL envoplakin
EXOSC9 exosome component 9
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GBAP1 glucosidase, beta, acid pseudogene 1
GBX2 gastrulation brain homeobox 2
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GPR21 G protein-coupled receptor 21
GPR87 G protein-coupled receptor 87
GRAMD3 GRAM domain containing 3
HAS2 hyaluronan synthase 2
HK2 hexokinase 2
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL15RA interleukin 15 receptor, alpha
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIFC1 kinesin family member C1
LENEP lens epithelial protein
LGALS13 lectin, galactoside-binding, soluble, 13
LMNB1 lamin B1
LOC440895 two pore channel 3 pseudogene
LOC441601 septin 7 pseudogene
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LZTS3 leucine zipper, putative tumor suppressor family member 3
MCM10 minichromosome maintenance complex component 10
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MICA MHC class I polypeptide-related sequence A
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MOCS3 molybdenum cofactor synthesis 3
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
MYOZ3 myozenin 3
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
OPRK1 opioid receptor, kappa 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PADI1 peptidyl arginine deiminase, type I
PAK1IP1 PAK1 interacting protein 1
PDE12 phosphodiesterase 12
PFAS phosphoribosylformylglycinamidine synthase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PISD phosphatidylserine decarboxylase
PLEKHO2 pleckstrin homology domain containing, family O member 2
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PRAME preferentially expressed antigen in melanoma
PTGFR prostaglandin F receptor (FP)
PTX3 pentraxin 3, long
PUS1 pseudouridylate synthase 1
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RIPPLY3 ripply transcriptional repressor 3
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPIA ribose 5-phosphate isomerase A
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSG1 REM2 and RAB-like small GTPase 1
SFTPA2 surfactant protein A2
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SMYD5 SMYD family member 5
STAT5A signal transducer and activator of transcription 5A
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TET3 tet methylcytosine dioxygenase 3
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TMEM110 transmembrane protein 110
TMEM209 transmembrane protein 209
TMEM51 transmembrane protein 51
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRAF5 TNF receptor-associated factor 5
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TUBA4A tubulin, alpha 4a
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
XPA xeroderma pigmentosum, complementation group A
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZDHHC6 zinc finger, DHHC-type containing 6