LY-294002-501 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the LY-294002-501 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADGRG1 adhesion G protein-coupled receptor G1
APOL3 apolipoprotein L, 3
APP amyloid beta (A4) precursor protein
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
AVL9 AVL9 homolog (S. cerevisiase)
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BICD1 bicaudal D homolog 1 (Drosophila)
BMP7 bone morphogenetic protein 7
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BTBD2 BTB (POZ) domain containing 2
CADM3 cell adhesion molecule 3
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CHD3 chromodomain helicase DNA binding protein 3
CHMP1B charged multivesicular body protein 1B
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CLDN15 claudin 15
CROT carnitine O-octanoyltransferase
CUX1 cut-like homeobox 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH2 cytohesin 2
DCP1A decapping mRNA 1A
DPF2 D4, zinc and double PHD fingers family 2
DSG3 desmoglein 3
EMC1 ER membrane protein complex subunit 1
ENOSF1 enolase superfamily member 1
ERCC8 excision repair cross-complementation group 8
FBXL2 F-box and leucine-rich repeat protein 2
FGFR1 fibroblast growth factor receptor 1
FLNC filamin C, gamma
FOXD1 forkhead box D1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FRS3 fibroblast growth factor receptor substrate 3
FUT2 fucosyltransferase 2 (secretor status included)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPR4 G protein-coupled receptor 4
GSTZ1 glutathione S-transferase zeta 1
HIST1H2AC histone cluster 1, H2ac
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXB5 homeobox B5
HPSE heparanase
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IL15RA interleukin 15 receptor, alpha
ING4 inhibitor of growth family, member 4
ISYNA1 inositol-3-phosphate synthase 1
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KIAA1467 KIAA1467
KIFC1 kinesin family member C1
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT2 keratin 2, type II
KYNU kynureninase
LINC00339 long intergenic non-protein coding RNA 339
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP2K5 mitogen-activated protein kinase kinase 5
MBOAT7 membrane bound O-acyltransferase domain containing 7
MOB3B MOB kinase activator 3B
MPPE1 metallophosphoesterase 1
MST1L macrophage stimulating 1-like
N4BP2L2 NEDD4 binding protein 2-like 2
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NADK NAD kinase
NCR2 natural cytotoxicity triggering receptor 2
NIPAL2 NIPA-like domain containing 2
NKTR natural killer cell triggering receptor
NPR2 natriuretic peptide receptor 2
PARG poly (ADP-ribose) glycohydrolase
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRDX2 peroxiredoxin 2
PRSS3 protease, serine, 3
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBKS ribokinase
RGS11 regulator of G-protein signaling 11
RIMS2 regulating synaptic membrane exocytosis 2
RPS2 ribosomal protein S2
SH3GL3 SH3-domain GRB2-like 3
SOAT1 sterol O-acyltransferase 1
SORBS2 sorbin and SH3 domain containing 2
SSH3 slingshot protein phosphatase 3
STK25 serine/threonine kinase 25
TNK2 tyrosine kinase, non-receptor, 2
UBE4B ubiquitination factor E4B
UBOX5 U-box domain containing 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WAS Wiskott-Aldrich syndrome
WDR1 WD repeat domain 1
ZFR zinc finger RNA binding protein
ZNF224 zinc finger protein 224
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRA2C adrenoceptor alpha 2C
ASRGL1 asparaginase like 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHMT betaine--homocysteine S-methyltransferase
BMP15 bone morphogenetic protein 15
BRIX1 BRX1, biogenesis of ribosomes
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C9ORF3 chromosome 9 open reading frame 3
CCL16 chemokine (C-C motif) ligand 16
CCL19 chemokine (C-C motif) ligand 19
CD27 CD27 molecule
CD53 CD53 molecule
CDCA8 cell division cycle associated 8
CREB5 cAMP responsive element binding protein 5
CTNNBIP1 catenin, beta interacting protein 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DAGLA diacylglycerol lipase, alpha
DCLRE1A DNA cross-link repair 1A
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DGKG diacylglycerol kinase, gamma 90kDa
DNASE1L2 deoxyribonuclease I-like 2
DPP3 dipeptidyl-peptidase 3
DRP2 dystrophin related protein 2
EN1 engrailed homeobox 1
EXOSC9 exosome component 9
FAM188A family with sequence similarity 188, member A
FANCG Fanconi anemia, complementation group G
G0S2 G0/G1 switch 2
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GDF10 growth differentiation factor 10
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNRH2 gonadotropin-releasing hormone 2
GPATCH1 G patch domain containing 1
GPN1 GPN-loop GTPase 1
HAS2 hyaluronan synthase 2
HELLS helicase, lymphoid-specific
HHLA1 HERV-H LTR-associating 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFALS insulin-like growth factor binding protein, acid labile subunit
KIF20B kinesin family member 20B
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LGALS13 lectin, galactoside-binding, soluble, 13
LHX6 LIM homeobox 6
LIF leukemia inhibitory factor
LINC00474 long intergenic non-protein coding RNA 474
LY6G6D lymphocyte antigen 6 complex, locus G6D
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK3 mitogen-activated protein kinase 3
MECR mitochondrial trans-2-enoyl-CoA reductase
MIR600HG MIR600 host gene
MMP12 matrix metallopeptidase 12
MMP27 matrix metallopeptidase 27
MT1H metallothionein 1H
MTERF4 mitochondrial transcription termination factor 4
MYO9A myosin IXA
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCAPH non-SMC condensin I complex, subunit H
NDOR1 NADPH dependent diflavin oxidoreductase 1
NOL6 nucleolar protein 6 (RNA-associated)
ORC1 origin recognition complex, subunit 1
PAK1IP1 PAK1 interacting protein 1
PAQR4 progestin and adipoQ receptor family member IV
PDE7B phosphodiesterase 7B
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLA2G10 phospholipase A2, group X
PLK1 polo-like kinase 1
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
POMT2 protein-O-mannosyltransferase 2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRDM11 PR domain containing 11
PRDM13 PR domain containing 13
PRODH2 proline dehydrogenase (oxidase) 2
RAB3D RAB3D, member RAS oncogene family
RASIP1 Ras interacting protein 1
RGR retinal G protein coupled receptor
RLN1 relaxin 1
RNF39 ring finger protein 39
RPL39L ribosomal protein L39-like
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNIP1 Smad nuclear interacting protein 1
SPP2 secreted phosphoprotein 2, 24kDa
STAB2 stabilin 2
SURF2 surfeit 2
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAS2R14 taste receptor, type 2, member 14
TGM5 transglutaminase 5
THEG theg spermatid protein
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176A transmembrane protein 176A
TMEM59L transmembrane protein 59-like
TMPRSS6 transmembrane protease, serine 6
UCK2 uridine-cytidine kinase 2
UGT8 UDP glycosyltransferase 8
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZIM2 zinc finger, imprinted 2