LY-294002-5236 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the LY-294002-5236 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM22 ADAM metallopeptidase domain 22
AGFG1 ArfGAP with FG repeats 1
AGGF1 angiogenic factor with G patch and FHA domains 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARMC4 armadillo repeat containing 4
ARNT aryl hydrocarbon receptor nuclear translocator
ARTN artemin
ASPH aspartate beta-hydroxylase
C21ORF2 chromosome 21 open reading frame 2
C8ORF44 chromosome 8 open reading frame 44
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CCNG2 cyclin G2
CDON cell adhesion associated, oncogene regulated
CEP295 centrosomal protein 295kDa
COL11A2 collagen, type XI, alpha 2
CPQ carboxypeptidase Q
CROCC ciliary rootlet coiled-coil, rootletin
CSF1 colony stimulating factor 1 (macrophage)
DGKQ diacylglycerol kinase, theta 110kDa
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP10 dual specificity phosphatase 10
ECE1 endothelin converting enzyme 1
EPN1 epsin 1
FHL1 four and a half LIM domains 1
FOXG1 forkhead box G1
GK3P glycerol kinase 3 pseudogene
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPER1 G protein-coupled estrogen receptor 1
GPR137 G protein-coupled receptor 137
GPR153 G protein-coupled receptor 153
HDAC7 histone deacetylase 7
HFE hemochromatosis
HIST1H3E histone cluster 1, H3e
HMOX1 heme oxygenase 1
IFT27 intraflagellar transport 27
IL36G interleukin 36, gamma
ING2 inhibitor of growth family, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LTBP4 latent transforming growth factor beta binding protein 4
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MBD1 methyl-CpG binding domain protein 1
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
MX1 MX dynamin-like GTPase 1
MYH14 myosin, heavy chain 14, non-muscle
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NLRX1 NLR family member X1
NPM3 nucleophosmin/nucleoplasmin 3
NRSN2 neurensin 2
OVOL2 ovo-like zinc finger 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCNX pecanex homolog (Drosophila)
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHF20 PHD finger protein 20
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PVRL3 poliovirus receptor-related 3
RAB30 RAB30, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RECQL5 RecQ protein-like 5
RTN2 reticulon 2
S100A13 S100 calcium binding protein A13
SATB2 SATB homeobox 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SMIM14 small integral membrane protein 14
SNX13 sorting nexin 13
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPTBN1 spectrin, beta, non-erythrocytic 1
SUGP1 SURP and G patch domain containing 1
SYNDIG1 synapse differentiation inducing 1
THBS3 thrombospondin 3
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMEM53 transmembrane protein 53
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIM66 tripartite motif containing 66
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TTC9 tetratricopeptide repeat domain 9
TUBA3C tubulin, alpha 3c
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
XYLB xylulokinase homolog (H. influenzae)
YTHDC1 YTH domain containing 1
ZNF440 zinc finger protein 440
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
BPGM 2,3-bisphosphoglycerate mutase
BTF3P12 basic transcription factor 3 pseudogene 12
C1ORF105 chromosome 1 open reading frame 105
CA11 carbonic anhydrase XI
CCDC130 coiled-coil domain containing 130
CCNO cyclin O
CEMIP cell migration inducing protein, hyaluronan binding
CEP170B centrosomal protein 170B
CHKB choline kinase beta
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLDN15 claudin 15
CLEC16A C-type lectin domain family 16, member A
CORT cortistatin
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DENND1A DENN/MADD domain containing 1A
DENND4B DENN/MADD domain containing 4B
DVL1 dishevelled segment polarity protein 1
EXD3 exonuclease 3'-5' domain containing 3
FAM110B family with sequence similarity 110, member B
FAM184A family with sequence similarity 184, member A
FAM186A family with sequence similarity 186, member A
FSD1 fibronectin type III and SPRY domain containing 1
FURIN furin (paired basic amino acid cleaving enzyme)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLRA1 glycine receptor, alpha 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRPR gastrin-releasing peptide receptor
GSTTP1 glutathione S-transferase theta pseudogene 1
HOXA4 homeobox A4
HSPA1L heat shock 70kDa protein 1-like
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL17RB interleukin 17 receptor B
IL4R interleukin 4 receptor
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KAT2A K(lysine) acetyltransferase 2A
KDM5C lysine (K)-specific demethylase 5C
KIF13B kinesin family member 13B
KRI1 KRI1 homolog (S. cerevisiae)
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMCD1 LIM and cysteine-rich domains 1
LTBP3 latent transforming growth factor beta binding protein 3
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAMLD1 mastermind-like domain containing 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MNX1 motor neuron and pancreas homeobox 1
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MYO1F myosin IF
N4BP3 NEDD4 binding protein 3
NES nestin
NPIPB15 nuclear pore complex interacting protein family, member B15
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PELP1 proline, glutamate and leucine rich protein 1
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLEKHO1 pleckstrin homology domain containing, family O member 1
QPCT glutaminyl-peptide cyclotransferase
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAI14 retinoic acid induced 14
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RNF126P1 ring finger protein 126 pseudogene 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPAP1 RNA polymerase II associated protein 1
RPGR retinitis pigmentosa GTPase regulator
RPL13P5 ribosomal protein L13 pseudogene 5
SEPP1 selenoprotein P, plasma, 1
SERTAD3 SERTA domain containing 3
SETD8 SET domain containing (lysine methyltransferase) 8
SIX1 SIX homeobox 1
SLC22A14 solute carrier family 22, member 14
SLIT2 slit homolog 2 (Drosophila)
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPHK1 sphingosine kinase 1
STBD1 starch binding domain 1
STEAP3 STEAP family member 3, metalloreductase
STRA6 stimulated by retinoic acid 6
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBX19 T-box 19
TCTN2 tectonic family member 2
TH tyrosine hydroxylase
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM212 transmembrane protein 212
TPCN1 two pore segment channel 1
TSLIG2 tRNA splicing ligase complex subunit 2
TTLL1 tubulin tyrosine ligase-like family member 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP6NL USP6 N-terminal like
ZBTB22 zinc finger and BTB domain containing 22
ZNF35 zinc finger protein 35
ZNF428 zinc finger protein 428
ZNF446 zinc finger protein 446
ZNF580 zinc finger protein 580
ZNF750 zinc finger protein 750