LY-294002-5970 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the LY-294002-5970 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHNAK AHNAK nucleoprotein
AMT aminomethyltransferase
ANXA10 annexin A10
ARHGAP28 Rho GTPase activating protein 28
ARL14 ADP-ribosylation factor-like 14
ATP9A ATPase, class II, type 9A
C1QTNF3 C1q and tumor necrosis factor related protein 3
C5ORF45 chromosome 5 open reading frame 45
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAV2 caveolin 2
CCDC134 coiled-coil domain containing 134
CCNG2 cyclin G2
CDKL3 cyclin-dependent kinase-like 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP68 centrosomal protein 68kDa
CRMP1 collapsin response mediator protein 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTGF connective tissue growth factor
DEPTOR DEP domain containing MTOR-interacting protein
DGCR8 DGCR8 microprocessor complex subunit
ESRRG estrogen-related receptor gamma
FH fumarate hydratase
FLJ10038 uncharacterized protein FLJ10038
GADD45B growth arrest and DNA-damage-inducible, beta
GALK1 galactokinase 1
GLCE glucuronic acid epimerase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH2L G patch domain containing 2-like
HAUS5 HAUS augmin-like complex, subunit 5
HBP1 HMG-box transcription factor 1
HEMK1 HemK methyltransferase family member 1
HIST1H2BC histone cluster 1, H2bc
HIST3H2A histone cluster 3, H2a
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFT54 intraflagellar transport 54
IL15 interleukin 15
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB4 integrin, beta 4
KIAA0319L KIAA0319-like
KLHL22 kelch-like family member 22
KLHL24 kelch-like family member 24
LAMA4 laminin, alpha 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MMP13 matrix metallopeptidase 13
MOXD1 monooxygenase, DBH-like 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MXD4 MAX dimerization protein 4
MYH14 myosin, heavy chain 14, non-muscle
NADK NAD kinase
NOL10 nucleolar protein 10
NR4A2 nuclear receptor subfamily 4, group A, member 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSR2 odd-skipped related transciption factor 2
OTUD4 OTU deubiquitinase 4
PDE4DIP phosphodiesterase 4D interacting protein
PHEX phosphate regulating endopeptidase homolog, X-linked
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLCD1 phospholipase C, delta 1
PLD1 phospholipase D1, phosphatidylcholine-specific
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RECQL5 RecQ protein-like 5
RNFT1 ring finger protein, transmembrane 1
SAMD4A sterile alpha motif domain containing 4A
SCIN scinderin
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH2D3A SH2 domain containing 3A
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLN sarcolipin
SMC1A structural maintenance of chromosomes 1A
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STON1 stonin 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBX19 T-box 19
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TDRKH tudor and KH domain containing
TESK2 testis-specific kinase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TK2 thymidine kinase 2, mitochondrial
TM2D1 TM2 domain containing 1
UBE3B ubiquitin protein ligase E3B
WAS Wiskott-Aldrich syndrome
WDR59 WD repeat domain 59
YPEL1 yippee-like 1 (Drosophila)
ZBTB20 zinc finger and BTB domain containing 20
ZMYND8 zinc finger, MYND-type containing 8
ZNF334 zinc finger protein 334
ZNF606 zinc finger protein 606
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADGRB2 adhesion G protein-coupled receptor B2
AEN apoptosis enhancing nuclease
ASPHD1 aspartate beta-hydroxylase domain containing 1
BEX1 brain expressed, X-linked 1
BYSL bystin-like
C1ORF105 chromosome 1 open reading frame 105
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CCDC86 coiled-coil domain containing 86
CEP295 centrosomal protein 295kDa
CLCN5 chloride channel, voltage-sensitive 5
COA7 cytochrome c oxidase assembly factor 7 (putative)
COBL cordon-bleu WH2 repeat protein
COL17A1 collagen, type XVII, alpha 1
CPNE7 copine VII
CTPS1 CTP synthase 1
CUTC cutC copper transporter
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDIT4 DNA-damage-inducible transcript 4
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DKFZP434C153 DKFZP434C153 protein
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC8 excision repair cross-complementation group 8
FAM53B family with sequence similarity 53, member B
FGFBP1 fibroblast growth factor binding protein 1
FXN frataxin
GJA9 gap junction protein, alpha 9, 59kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GMEB1 glucocorticoid modulatory element binding protein 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR3 G protein-coupled receptor 3
GPR87 G protein-coupled receptor 87
HABP2 hyaluronan binding protein 2
HAS2 hyaluronan synthase 2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IL12A interleukin 12A
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA1456 KIAA1456
LIME1 Lck interacting transmembrane adaptor 1
LIPG lipase, endothelial
LONRF3 LON peptidase N-terminal domain and ring finger 3
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MICALL2 MICAL-like 2
MORN1 MORN repeat containing 1
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL28 mitochondrial ribosomal protein L28
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MT1M metallothionein 1M
MYOZ1 myozenin 1
NOL6 nucleolar protein 6 (RNA-associated)
NPR3 natriuretic peptide receptor 3
NXPE4 neurexophilin and PC-esterase domain family, member 4
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PALMD palmdelphin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE12 phosphodiesterase 12
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POU5F1B POU class 5 homeobox 1B
PRAME preferentially expressed antigen in melanoma
PRICKLE3 prickle homolog 3 (Drosophila)
PTGFR prostaglandin F receptor (FP)
RGS19 regulator of G-protein signaling 19
RGS20 regulator of G-protein signaling 20
RRP1 ribosomal RNA processing 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A3 S100 calcium binding protein A3
SAMD9 sterile alpha motif domain containing 9
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SOSTDC1 sclerostin domain containing 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TRIM16 tripartite motif containing 16
TRIM25 tripartite motif containing 25
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTC27 tetratricopeptide repeat domain 27
TUBA4A tubulin, alpha 4a
TUBB7P tubulin, beta 7, pseudogene
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WFDC8 WAP four-disulfide core domain 8
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YOD1 YOD1 deubiquitinase
ZFP69B ZFP69 zinc finger protein B
ZHX2 zinc fingers and homeoboxes 2
ZNF573 zinc finger protein 573
ZNF639 zinc finger protein 639
ZNF787 zinc finger protein 787