| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY2090314 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY2090314_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.104165 |
| CDH13 | cadherin 13 | 0.0888196 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0799849 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0715073 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0504047 |
| PODXL | podocalyxin-like | 0.044485 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0399919 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0397845 |
| ASPH | aspartate beta-hydroxylase | 0.0391492 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0373587 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0351723 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0346604 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0338233 |
| EGFR | epidermal growth factor receptor | 0.0333621 |
| LMNA | lamin A/C | 0.031559 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0314965 |
| PLAT | plasminogen activator, tissue | 0.0279761 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0267273 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.02559 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0255255 |
| CSTB | cystatin B (stefin B) | 0.0252453 |
| EFNA5 | ephrin-A5 | 0.0248712 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0243602 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0234484 |
| DST | dystonin | 0.0233602 |
| CYTH3 | cytohesin 3 | 0.0232838 |
| MAP1B | microtubule-associated protein 1B | 0.0230601 |
| FN1 | fibronectin 1 | 0.0229808 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0215825 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0209996 |
| HDAC9 | histone deacetylase 9 | 0.0209782 |
| COL5A1 | collagen, type V, alpha 1 | 0.0209417 |
| FLT1 | fms-related tyrosine kinase 1 | 0.0207108 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 0.0204326 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0203477 |
| VEGFC | vascular endothelial growth factor C | 0.0194689 |
| INTS6 | integrator complex subunit 6 | 0.0191492 |
| CALR | calreticulin | 0.0191409 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.019034 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0189736 |
| RND3 | Rho family GTPase 3 | 0.0179467 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0168165 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0165199 |
| FMN2 | formin 2 | 0.0163624 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0162405 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0159073 |
| ADAM32 | ADAM metallopeptidase domain 32 | 0.0157265 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.015655 |
| GOLGB1 | golgin B1 | 0.0155491 |
| ANXA1 | annexin A1 | 0.015142 |
| TPM4 | tropomyosin 4 | 0.0145124 |
| PLXNA2 | plexin A2 | 0.0143977 |
| MSN | moesin | 0.0142053 |
| SP100 | SP100 nuclear antigen | 0.0141521 |
| CEP170 | centrosomal protein 170kDa | 0.0140525 |
| RASAL2 | RAS protein activator like 2 | 0.0134841 |
| KIAA1549L | KIAA1549-like | 0.0134273 |
| ANKRD30B | ankyrin repeat domain 30B | 0.012952 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.0129472 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0127786 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0127594 |
| LRRC17 | leucine rich repeat containing 17 | 0.0127513 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.0123423 |
| PCDH7 | protocadherin 7 | 0.0122674 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0122207 |
| SEPTIN9 | septin 9 | 0.0121392 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0118769 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0117875 |
| BTBD10 | BTB (POZ) domain containing 10 | 0.0116551 |
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.0115101 |
| DCLK2 | doublecortin-like kinase 2 | 0.0115057 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0114583 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0114344 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0114177 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0113985 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0113506 |
| NUCB2 | nucleobindin 2 | 0.0111962 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0111079 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0109116 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.0108571 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0108519 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | 0.0107811 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0107471 |
| ERBIN | erbb2 interacting protein | 0.0107367 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0106557 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.0105217 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0103102 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | 0.0102496 |
| CUX1 | cut-like homeobox 1 | 0.0102434 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.010232 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0101839 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0100654 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.00987895 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0098115 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.00972262 |
| VIM | vimentin | 0.00961095 |
| ACER3 | alkaline ceramidase 3 | 0.00958724 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.00946951 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.00937021 |
| LDHA | lactate dehydrogenase A | 0.00934305 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FBN1 | fibrillin 1 | -0.128993 |
| UBC | ubiquitin C | -0.0960147 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0873033 |
| TMSB10 | thymosin beta 10 | -0.0815099 |
| COL1A2 | collagen, type I, alpha 2 | -0.0754413 |
| COL3A1 | collagen, type III, alpha 1 | -0.0724794 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.066632 |
| AHNAK | AHNAK nucleoprotein | -0.06502 |
| CD44 | CD44 molecule (Indian blood group) | -0.058719 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0563183 |
| LOX | lysyl oxidase | -0.055591 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.055413 |
| LOXL2 | lysyl oxidase-like 2 | -0.0546594 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0542535 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0535103 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0427456 |
| COL5A2 | collagen, type V, alpha 2 | -0.0426138 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0404771 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0392134 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0384088 |
| MT2A | metallothionein 2A | -0.0376746 |
| STC1 | stanniocalcin 1 | -0.0368728 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0361022 |
| THBS2 | thrombospondin 2 | -0.035835 |
| APP | amyloid beta (A4) precursor protein | -0.035149 |
| FLNB | filamin B, beta | -0.0350496 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0348824 |
| GPC6 | glypican 6 | -0.0336245 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0321821 |
| SBF2 | SET binding factor 2 | -0.0315091 |
| SQSTM1 | sequestosome 1 | -0.0308406 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0302096 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0282257 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0281119 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0280371 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0279001 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0276522 |
| ATP13A3 | ATPase type 13A3 | -0.0263369 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0259322 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0257057 |
| OGA | O-GlcNAcase | -0.0254516 |
| HDLBP | high density lipoprotein binding protein | -0.02503 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0250154 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0247178 |
| HLA-E | major histocompatibility complex, class I, E | -0.0242995 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0237519 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0233258 |
| RUNX1 | runt-related transcription factor 1 | -0.0232154 |
| AUTS2 | autism susceptibility candidate 2 | -0.0231063 |
| ACTN4 | actinin, alpha 4 | -0.0229874 |
| NAV2 | neuron navigator 2 | -0.0224946 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0223886 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0220277 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.021773 |
| HLA-B | major histocompatibility complex, class I, B | -0.0217573 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0215165 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0210914 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0210302 |
| ADAR | adenosine deaminase, RNA-specific | -0.0209496 |
| TMSB4X | thymosin beta 4, X-linked | -0.0207973 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0205678 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0205567 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0204424 |
| SPAG9 | sperm associated antigen 9 | -0.020311 |
| GLIS3 | GLIS family zinc finger 3 | -0.0202543 |
| MEIS2 | Meis homeobox 2 | -0.02004 |
| PGK1 | phosphoglycerate kinase 1 | -0.0198819 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.019833 |
| MX2 | MX dynamin-like GTPase 2 | -0.0197271 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.0194196 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0192822 |
| FLNA | filamin A, alpha | -0.0191352 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0189379 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0187763 |
| WTAP | Wilms tumor 1 associated protein | -0.0187761 |
| TMOD1 | tropomodulin 1 | -0.0187492 |
| NAV1 | neuron navigator 1 | -0.0186378 |
| PTMA | prothymosin, alpha | -0.0183002 |
| ARRDC3 | arrestin domain containing 3 | -0.018131 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0179932 |
| ZNF217 | zinc finger protein 217 | -0.0179367 |
| NF1 | neurofibromin 1 | -0.0178622 |
| RPS27A | ribosomal protein S27a | -0.0178139 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0177128 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0176242 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0174873 |
| C1D | C1D nuclear receptor corepressor | -0.0173824 |
| CALU | calumenin | -0.0172662 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0172366 |
| NPR2 | natriuretic peptide receptor 2 | -0.0171614 |
| SDC4 | syndecan 4 | -0.017102 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0169813 |
| SLC22A23 | solute carrier family 22, member 23 | -0.0165733 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0165443 |
| FRMD5 | FERM domain containing 5 | -0.0165354 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0164472 |
| PKM | pyruvate kinase, muscle | -0.0164383 |
| SP3 | Sp3 transcription factor | -0.0162234 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.01621 |
| RPL23 | ribosomal protein L23 | -0.0160512 |
