LY2090314_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY2090314 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY2090314_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.194907
HMGA2 high mobility group AT-hook 2 0.145938
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0822791
INTS6 integrator complex subunit 6 0.0763954
YAP1 Yes-associated protein 1 0.0759667
ASPH aspartate beta-hydroxylase 0.0611511
PDE4D phosphodiesterase 4D, cAMP-specific 0.0585942
EHBP1 EH domain binding protein 1 0.0546621
LDHA lactate dehydrogenase A 0.0527986
DST dystonin 0.0487067
ZSWIM6 zinc finger, SWIM-type containing 6 0.047591
AREG amphiregulin 0.0431264
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0430862
TAS2R14 taste receptor, type 2, member 14 0.0423238
DENND5A DENN/MADD domain containing 5A 0.041998
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0410327
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0393196
LRRC23 leucine rich repeat containing 23 0.0331029
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0324701
BABAM2 BRISC and BRCA1 A complex member 2 0.0322361
MGAT4C MGAT4 family, member C 0.0320529
PCDH9 protocadherin 9 0.0316437
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.031227
EDARADD EDAR-associated death domain 0.0309364
NEBL nebulette 0.0308968
GOLGB1 golgin B1 0.030321
MACF1 microtubule-actin crosslinking factor 1 0.0300086
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0298868
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0294426
AHRR aryl-hydrocarbon receptor repressor 0.0289732
ETV6 ets variant 6 0.0282835
VDAC1 voltage-dependent anion channel 1 0.0280064
NRDC nardilysin convertase 0.027667
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0276289
ASXL1 additional sex combs like transcriptional regulator 1 0.0275834
KDM4C lysine (K)-specific demethylase 4C 0.0273469
ZEB1 zinc finger E-box binding homeobox 1 0.0267203
RPS3 ribosomal protein S3 0.0265341
MBD5 methyl-CpG binding domain protein 5 0.025779
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0251703
ZNF804A zinc finger protein 804A 0.0251364
PAPOLA poly(A) polymerase alpha 0.0250373
RRM2 ribonucleotide reductase M2 0.0249588
BRD2 bromodomain containing 2 0.0246908
DTNA dystrobrevin, alpha 0.0245613
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0245543
RCOR1 REST corepressor 1 0.0240961
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0226878
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0226065
LPP LIM domain containing preferred translocation partner in lipoma 0.0223948
HSPA8 heat shock 70kDa protein 8 0.0222115
PRH1 proline-rich protein HaeIII subfamily 1 0.0221395
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0221098
MCF2L MCF.2 cell line derived transforming sequence-like 0.0217807
TIMP2 TIMP metallopeptidase inhibitor 2 0.021702
ANKRD17 ankyrin repeat domain 17 0.0216604
ASXL2 additional sex combs like transcriptional regulator 2 0.0215276
CREM cAMP responsive element modulator 0.0215127
MYPN myopalladin 0.021336
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0213222
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0212878
TPM4 tropomyosin 4 0.0212871
SERTAD2 SERTA domain containing 2 0.0212379
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0211815
FGFR1 fibroblast growth factor receptor 1 0.0211001
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0210428
EXOC4 exocyst complex component 4 0.0206999
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0205792
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0205036
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0205035
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0202814
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0201645
TBCA tubulin folding cofactor A 0.020038
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0200066
PTPRD protein tyrosine phosphatase, receptor type, D 0.019976
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0199571
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.0199287
HSPH1 heat shock 105kDa/110kDa protein 1 0.0198997
WWOX WW domain containing oxidoreductase 0.0194176
FBXL7 F-box and leucine-rich repeat protein 7 0.0193188
DUSP16 dual specificity phosphatase 16 0.0190755
STAU1 staufen double-stranded RNA binding protein 1 0.0189877
ANK2 ankyrin 2, neuronal 0.0189129
MSRB3 methionine sulfoxide reductase B3 0.0188902
LRMDA leucine rich melanocyte differentiation associated 0.0187864
PCLO piccolo presynaptic cytomatrix protein 0.0187755
CCSER1 coiled-coil serine-rich protein 1 0.0187275
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0186625
STAU2 staufen double-stranded RNA binding protein 2 0.0186157
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0184101
AVIL advillin 0.0183633
R3HDM2 R3H domain containing 2 0.0182969
TTC3 tetratricopeptide repeat domain 3 0.0180481
AGO3 argonaute RISC catalytic component 3 0.0178752
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0178499
COL5A2 collagen, type V, alpha 2 0.0176913
FXR1 fragile X mental retardation, autosomal homolog 1 0.0175077
AATF apoptosis antagonizing transcription factor 0.0174238
NAP1L1 nucleosome assembly protein 1-like 1 0.0172031
MKI67 marker of proliferation Ki-67 0.0171784

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.268741
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.102442
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.088108
MYL12B myosin, light chain 12B, regulatory -0.0862942
RPLP1 ribosomal protein, large, P1 -0.0746929
TXNRD1 thioredoxin reductase 1 -0.0733608
RPL23 ribosomal protein L23 -0.069717
DPYD dihydropyrimidine dehydrogenase -0.0686679
RPL35A ribosomal protein L35a -0.0659657
TMEM41B transmembrane protein 41B -0.063385
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0614591
RPS19 ribosomal protein S19 -0.0585344
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0584604
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0582643
PTMS parathymosin -0.0556553
VIM vimentin -0.0551187
CNRIP1 cannabinoid receptor interacting protein 1 -0.053613
AHNAK AHNAK nucleoprotein -0.0531286
RPS21 ribosomal protein S21 -0.0516661
RPLP2 ribosomal protein, large, P2 -0.0461396
LMO7 LIM domain 7 -0.0460608
ATP5F1B ATP synthase F1 subunit beta -0.0446722
RPS6 ribosomal protein S6 -0.041895
DLC1 DLC1 Rho GTPase activating protein -0.0414288
KIF18B kinesin family member 18B -0.0413281
SLC38A2 solute carrier family 38, member 2 -0.0411696
RPS16 ribosomal protein S16 -0.0405386
CELF2 CUGBP, Elav-like family member 2 -0.0400687
MATR3 matrin 3 -0.039041
TNPO1 transportin 1 -0.038681
ANKRD12 ankyrin repeat domain 12 -0.0384865
RPL19 ribosomal protein L19 -0.0374243
CCN2 cellular communication network factor 2 -0.0373434
ADGRG6 adhesion G protein-coupled receptor G6 -0.0371679
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0371159
RPS27 ribosomal protein S27 -0.0366064
CLDN1 claudin 1 -0.0365526
ECT2 epithelial cell transforming 2 -0.0362546
RAB1A RAB1A, member RAS oncogene family -0.0361824
MARCHF6 membrane associated ring-CH-type finger 6 -0.0360718
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0358464
RPS14 ribosomal protein S14 -0.0356228
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0350915
S100A6 S100 calcium binding protein A6 -0.0350881
NLGN1 neuroligin 1 -0.0348666
GJA1 gap junction protein, alpha 1, 43kDa -0.0343881
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0340243
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0337472
SLC38A1 solute carrier family 38, member 1 -0.0330622
PFN1 profilin 1 -0.0323524
CBX3 chromobox homolog 3 -0.0321801
RPL11 ribosomal protein L11 -0.0321707
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0317459
XPO1 exportin 1 -0.0314083
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0313901
RBM25 RNA binding motif protein 25 -0.0311517
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0308399
EEF2 eukaryotic translation elongation factor 2 -0.0302494
KLHL24 kelch-like family member 24 -0.0300528
FUS FUS RNA binding protein -0.0299565
WDR43 WD repeat domain 43 -0.0297976
HMGA1 high mobility group AT-hook 1 -0.0295832
CPOX coproporphyrinogen oxidase -0.0290545
EDN1 endothelin 1 -0.0287638
RPL36A ribosomal protein L36a -0.0287619
ADNP activity-dependent neuroprotector homeobox -0.0286417
ZBTB20 zinc finger and BTB domain containing 20 -0.028579
NEK7 NIMA-related kinase 7 -0.0285093
NCEH1 neutral cholesterol ester hydrolase 1 -0.0284077
RPL8 ribosomal protein L8 -0.0282688
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0282545
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0280179
SQSTM1 sequestosome 1 -0.0280149
BIRC6 baculoviral IAP repeat containing 6 -0.0279016
FTL ferritin, light polypeptide -0.0278012
RPL36 ribosomal protein L36 -0.0277032
RAD21 RAD21 homolog (S. pombe) -0.027649
CXADR coxsackie virus and adenovirus receptor -0.0276378
RASAL2 RAS protein activator like 2 -0.02753
PGK1 phosphoglycerate kinase 1 -0.0274583
RPL32 ribosomal protein L32 -0.0272986
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0269214
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0268517
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0265846
PCBP2 poly(rC) binding protein 2 -0.0264179
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.026354
CCNL1 cyclin L1 -0.02626
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0260479
RPL34 ribosomal protein L34 -0.0260228
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0258979
TBK1 TANK-binding kinase 1 -0.0256115
HSPB1 heat shock 27kDa protein 1 -0.0255351
ZFR zinc finger RNA binding protein -0.0251292
KDM3A lysine (K)-specific demethylase 3A -0.0250314
SBF2 SET binding factor 2 -0.0246218
BCAS3 breast carcinoma amplified sequence 3 -0.0243447
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0243001
RPS27A ribosomal protein S27a -0.0242856
IPO7 importin 7 -0.024132
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0241185