LY2090314_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY2090314 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY2090314_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.127827
INTS6 integrator complex subunit 6 0.123845
PARP14 poly (ADP-ribose) polymerase family, member 14 0.106358
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0893106
PHF3 PHD finger protein 3 0.0866315
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0751963
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0746167
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0743627
GCLC glutamate-cysteine ligase, catalytic subunit 0.072713
XAF1 XIAP associated factor 1 0.062027
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0616873
EXT1 exostosin glycosyltransferase 1 0.0614448
RIGI RNA sensor RIG-I 0.0600836
SQSTM1 sequestosome 1 0.0592387
GOLGB1 golgin B1 0.0589005
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0582184
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0581419
ZBTB20 zinc finger and BTB domain containing 20 0.0574986
RNF213 ring finger protein 213 0.0568866
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0564183
ANXA2 annexin A2 0.0542722
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0539905
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.051982
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0473064
GCC2 GRIP and coiled-coil domain containing 2 0.0457353
KIAA1217 KIAA1217 0.0441887
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0435404
CANX calnexin 0.0428423
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0418261
RRBP1 ribosome binding protein 1 0.041757
MUC20 mucin 20, cell surface associated 0.0412125
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0408062
SP100 SP100 nuclear antigen 0.0407566
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0402136
SPATS2L spermatogenesis associated, serine-rich 2-like 0.03998
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0399714
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0392451
NCOA7 nuclear receptor coactivator 7 0.0383294
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0366604
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0365786
POF1B premature ovarian failure, 1B 0.0362984
TOX3 TOX high mobility group box family member 3 0.03629
TSC22D1 TSC22 domain family, member 1 0.0361969
KDM3A lysine (K)-specific demethylase 3A 0.0360895
SMAD3 SMAD family member 3 0.0360843
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0360603
ATP11A ATPase, class VI, type 11A 0.0358976
DST dystonin 0.0358433
KLF5 Kruppel-like factor 5 (intestinal) 0.035689
RSAD2 radical S-adenosyl methionine domain containing 2 0.0355447
TC2N tandem C2 domains, nuclear 0.0350395
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0339323
PLSCR2 phospholipid scramblase 2 0.0335146
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0331905
STAU1 staufen double-stranded RNA binding protein 1 0.0331156
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0320197
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0319003
ERRFI1 ERBB receptor feedback inhibitor 1 0.0318132
EPSTI1 epithelial stromal interaction 1 (breast) 0.0318002
NIPBL Nipped-B homolog (Drosophila) 0.0312575
TRIO trio Rho guanine nucleotide exchange factor 0.0304014
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0303063
CTBP2 C-terminal binding protein 2 0.0300042
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0299139
MAP7 microtubule-associated protein 7 0.0292718
USP53 ubiquitin specific peptidase 53 0.029178
RNF43 ring finger protein 43 0.0291395
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0289347
APP amyloid beta (A4) precursor protein 0.0284085
TM9SF2 transmembrane 9 superfamily member 2 0.0280985
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0280491
EPCAM epithelial cell adhesion molecule 0.0279082
JAK1 Janus kinase 1 0.02787
N4BP2L2 NEDD4 binding protein 2-like 2 0.0278441
TPR translocated promoter region, nuclear basket protein 0.0278104
RAD50 RAD50 homolog (S. cerevisiae) 0.0276644
MX1 MX dynamin-like GTPase 1 0.0274441
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0274358
SHB Src homology 2 domain containing adaptor protein B 0.0272306
IGF1R insulin-like growth factor 1 receptor 0.0271026
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0269682
MUC13 mucin 13, cell surface associated 0.0269396
BTBD9 BTB (POZ) domain containing 9 0.0266134
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0265875
TMC5 transmembrane channel-like 5 0.0265233
BICRAL BICRA like chromatin remodeling complex associated protein 0.0264361
MYH9 myosin, heavy chain 9, non-muscle 0.0263817
UTRN utrophin 0.026292
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0262809
EPHB2 EPH receptor B2 0.0261853
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0261667
DSPP dentin sialophosphoprotein 0.026082
IQGAP1 IQ motif containing GTPase activating protein 1 0.0257792
DPP4 dipeptidyl-peptidase 4 0.0257305
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0256812
TTC3 tetratricopeptide repeat domain 3 0.025661
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0256245
ANXA4 annexin A4 0.025369
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0250987
NKD1 naked cuticle homolog 1 (Drosophila) 0.0250697

decreased expression

Symbol Name Standardized Value
MACC1 metastasis associated in colon cancer 1 -0.0850367
B2M beta-2-microglobulin -0.0800884
ERBIN erbb2 interacting protein -0.0789968
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0658106
EGR1 early growth response 1 -0.0637224
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0594755
NDRG1 N-myc downstream regulated 1 -0.0577054
LYZ lysozyme -0.0549941
TMSB10 thymosin beta 10 -0.0513779
RAB7A RAB7A, member RAS oncogene family -0.0512369
POTEF POTE ankyrin domain family, member F -0.0471756
CCNL1 cyclin L1 -0.0462113
EFHD2 EF-hand domain family, member D2 -0.0401824
LY6E lymphocyte antigen 6 complex, locus E -0.0397865
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0397468
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0391833
IFI27 interferon, alpha-inducible protein 27 -0.0388895
FTH1 ferritin, heavy polypeptide 1 -0.0370509
UBC ubiquitin C -0.0364372
PTBP3 polypyrimidine tract binding protein 3 -0.0356783
CLDN4 claudin 4 -0.0342523
LOC112694756 uncharaterized LOC112694756 -0.0340674
ZNF292 zinc finger protein 292 -0.033438
RBM25 RNA binding motif protein 25 -0.0329072
PTMA prothymosin, alpha -0.032505
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0324378
TXNIP thioredoxin interacting protein -0.0316952
TJP1 tight junction protein 1 -0.031615
STS steroid sulfatase (microsomal), isozyme S -0.0314372
PLIN2 perilipin 2 -0.0302039
CTSD cathepsin D -0.0292444
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0285269
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0283635
RPS19 ribosomal protein S19 -0.0282475
ENO2 enolase 2 (gamma, neuronal) -0.028218
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0272164
PTEN phosphatase and tensin homolog -0.0271911
S100A6 S100 calcium binding protein A6 -0.0271528
ENO1 enolase 1, (alpha) -0.0270897
CBX3 chromobox homolog 3 -0.0264267
UGCG UDP-glucose ceramide glucosyltransferase -0.0263283
SRRM2 serine/arginine repetitive matrix 2 -0.0262536
PDE8A phosphodiesterase 8A -0.0260481
RHOBTB3 Rho-related BTB domain containing 3 -0.0259889
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0257128
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0254389
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0254219
SERF2 small EDRK-rich factor 2 -0.0253764
NPSR1 neuropeptide S receptor 1 -0.0253122
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0253107
NAV1 neuron navigator 1 -0.0251835
KRT19 keratin 19, type I -0.0250902
CXXC5 CXXC finger protein 5 -0.0247835
RPL35A ribosomal protein L35a -0.0247354
ZNF395 zinc finger protein 395 -0.0246316
ARHGAP26 Rho GTPase activating protein 26 -0.0246058
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0244788
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0243374
TMEM165 transmembrane protein 165 -0.0241739
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0241667
MUC1 mucin 1, cell surface associated -0.0239939
HLA-A major histocompatibility complex, class I, A -0.0239135
OCLN occludin -0.0235182
RPS24 ribosomal protein S24 -0.0234277
C6ORF132 chromosome 6 open reading frame 132 -0.0229162
UBE2H ubiquitin-conjugating enzyme E2H -0.0228427
S100A9 S100 calcium binding protein A9 -0.022354
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0220962
ZNF148 zinc finger protein 148 -0.0220905
LIMA1 LIM domain and actin binding 1 -0.0217275
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0216114
NCEH1 neutral cholesterol ester hydrolase 1 -0.021446
PERP PERP, TP53 apoptosis effector -0.0213154
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0212778
VEGFA vascular endothelial growth factor A -0.0208305
PFN1 profilin 1 -0.0207167
DIAPH3 diaphanous-related formin 3 -0.0205248
TPI1 triosephosphate isomerase 1 -0.020436
RPLP1 ribosomal protein, large, P1 -0.02037
SNX9 sorting nexin 9 -0.0202347
TUBA1B tubulin, alpha 1b -0.0199675
LYN LYN proto-oncogene, Src family tyrosine kinase -0.019966
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0198897
RPL19 ribosomal protein L19 -0.0198399
JUN jun proto-oncogene -0.0197553
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0196371
DDIT3 DNA-damage-inducible transcript 3 -0.0195024
RPS21 ribosomal protein S21 -0.0193736
MXD1 MAX dimerization protein 1 -0.0190211
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0189596
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0189434
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0189273
TAGLN2 transgelin 2 -0.0189072
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0188654
TM4SF19 transmembrane 4 L six family member 19 -0.0188315
RSRC1 arginine/serine-rich coiled-coil 1 -0.0188069
ANKRD12 ankyrin repeat domain 12 -0.0188063
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0188044
KLHL24 kelch-like family member 24 -0.0186066
FOSL2 FOS-like antigen 2 -0.0185708