| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY2090314 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY2090314_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.250853 |
| CDH13 | cadherin 13 | 0.0372891 |
| GOLGB1 | golgin B1 | 0.0318943 |
| RPS6 | ribosomal protein S6 | 0.0238398 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0222109 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0217866 |
| RPS8 | ribosomal protein S8 | 0.0216061 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.020919 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0197464 |
| RND3 | Rho family GTPase 3 | 0.0191079 |
| B2M | beta-2-microglobulin | 0.017155 |
| MTDH | metadherin | 0.0170747 |
| RPS3 | ribosomal protein S3 | 0.0169309 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0154704 |
| FTL | ferritin, light polypeptide | 0.0151374 |
| RPL37A | ribosomal protein L37a | 0.0148168 |
| ATF4 | activating transcription factor 4 | 0.0147141 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0144621 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0144345 |
| VEGFA | vascular endothelial growth factor A | 0.0143132 |
| HDAC9 | histone deacetylase 9 | 0.0141595 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0138235 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0137194 |
| SP100 | SP100 nuclear antigen | 0.0133811 |
| SQSTM1 | sequestosome 1 | 0.013309 |
| LDHA | lactate dehydrogenase A | 0.0131751 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0130551 |
| RPS2 | ribosomal protein S2 | 0.0130274 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0127493 |
| RPL35A | ribosomal protein L35a | 0.0126956 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.012565 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.011803 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0116937 |
| FNIP1 | folliculin interacting protein 1 | 0.0110255 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0109427 |
| PGM3 | phosphoglucomutase 3 | 0.0108661 |
| GLRX | glutaredoxin (thioltransferase) | 0.0108038 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0106231 |
| BRD2 | bromodomain containing 2 | 0.0105788 |
| VCL | vinculin | 0.0104986 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0104126 |
| RPL11 | ribosomal protein L11 | 0.0104065 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0103263 |
| RPS13 | ribosomal protein S13 | 0.0102315 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.00999323 |
| EFNA5 | ephrin-A5 | 0.00984557 |
| INTS6 | integrator complex subunit 6 | 0.00977787 |
| RPL13A | ribosomal protein L13a | 0.00974695 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00974094 |
| RPS12 | ribosomal protein S12 | 0.00966678 |
| TLE4 | transducin-like enhancer of split 4 | 0.00960131 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00960078 |
| HM13 | histocompatibility (minor) 13 | 0.00947583 |
| RPL37 | ribosomal protein L37 | 0.00944371 |
| STC2 | stanniocalcin 2 | 0.00932356 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.00922641 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.00919424 |
| DSTN | destrin (actin depolymerizing factor) | 0.00914118 |
| GOLGA4 | golgin A4 | 0.009075 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0089997 |
| EXT1 | exostosin glycosyltransferase 1 | 0.00897822 |
| NUCB2 | nucleobindin 2 | 0.00848556 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.00842721 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.00814283 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.00811754 |
| ANKRD11 | ankyrin repeat domain 11 | 0.00796929 |
| RPL9 | ribosomal protein L9 | 0.0077955 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.00776006 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.00772517 |
| TBCA | tubulin folding cofactor A | 0.00765016 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0076111 |
| RPL31 | ribosomal protein L31 | 0.00758271 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.00745457 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | 0.00744598 |
| PAPOLA | poly(A) polymerase alpha | 0.00739762 |
| CDK13 | cyclin-dependent kinase 13 | 0.00736441 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.00735085 |
| ZNF644 | zinc finger protein 644 | 0.00731882 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.00728963 |
| SCFD1 | sec1 family domain containing 1 | 0.00726539 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.00725578 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.00723895 |
| GDI2 | GDP dissociation inhibitor 2 | 0.00721277 |
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.00720667 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.00717322 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.00716213 |
| OPTN | optineurin | 0.00716071 |
| FERMT2 | fermitin family member 2 | 0.00702491 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.00701106 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.00700953 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0069998 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.00689224 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.00685019 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.00677249 |
| TRIP11 | thyroid hormone receptor interactor 11 | 0.00674722 |
| KPNB1 | karyopherin (importin) beta 1 | 0.00674349 |
| PDCD5 | programmed cell death 5 | 0.00673423 |
| MYO1E | myosin IE | 0.0066628 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.00661785 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.00649715 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.128497 |
| COL1A1 | collagen, type I, alpha 1 | -0.120237 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0979939 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0644607 |
| TMSB10 | thymosin beta 10 | -0.0571439 |
| CD44 | CD44 molecule (Indian blood group) | -0.0534844 |
| UBC | ubiquitin C | -0.0522153 |
| COL1A2 | collagen, type I, alpha 2 | -0.0516908 |
| AHNAK | AHNAK nucleoprotein | -0.047889 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0446683 |
| MT2A | metallothionein 2A | -0.0382127 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0378494 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0371299 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0370922 |
| VIM | vimentin | -0.0370849 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0354641 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0353039 |
| MT1X | metallothionein 1X | -0.0312357 |
| INHBA | inhibin, beta A | -0.0302024 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0300765 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0291562 |
| CALU | calumenin | -0.0285286 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0282163 |
| ATP13A3 | ATPase type 13A3 | -0.0274101 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0263821 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0259678 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0254405 |
| COL5A1 | collagen, type V, alpha 1 | -0.0247436 |
| TMSB4X | thymosin beta 4, X-linked | -0.0238001 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0237215 |
| SMAD3 | SMAD family member 3 | -0.0237205 |
| LOXL2 | lysyl oxidase-like 2 | -0.0234999 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0233244 |
| FBN1 | fibrillin 1 | -0.0229082 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0217457 |
| CANX | calnexin | -0.0212736 |
| ENO1 | enolase 1, (alpha) | -0.0211869 |
| PKM | pyruvate kinase, muscle | -0.0211505 |
| VCAN | versican | -0.0206536 |
| PTMA | prothymosin, alpha | -0.0206371 |
| NDRG1 | N-myc downstream regulated 1 | -0.0203559 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0190773 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0189874 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0178999 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0177001 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0176969 |
| APP | amyloid beta (A4) precursor protein | -0.0174512 |
| ARRDC3 | arrestin domain containing 3 | -0.0169369 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0167426 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0167159 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0164873 |
| POSTN | periostin, osteoblast specific factor | -0.0162496 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0161828 |
| LOX | lysyl oxidase | -0.0159239 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0157905 |
| PLEC | plectin | -0.0156573 |
| HMGA2 | high mobility group AT-hook 2 | -0.0154914 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.01538 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0152116 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0150894 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0150189 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0149958 |
| COL4A1 | collagen, type IV, alpha 1 | -0.0149291 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.014742 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0147349 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0145573 |
| S100A6 | S100 calcium binding protein A6 | -0.0144663 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0144069 |
| FLNA | filamin A, alpha | -0.0142875 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0141036 |
| JUN | jun proto-oncogene | -0.0140933 |
| PDE10A | phosphodiesterase 10A | -0.0138737 |
| CLIC4 | chloride intracellular channel 4 | -0.0132883 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0132879 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0132825 |
| ACTN4 | actinin, alpha 4 | -0.0130698 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0130578 |
| FAT1 | FAT atypical cadherin 1 | -0.0128733 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0125998 |
| RLF | rearranged L-myc fusion | -0.0124946 |
| ZNF292 | zinc finger protein 292 | -0.0124164 |
| SBF2 | SET binding factor 2 | -0.0123995 |
| NRP1 | neuropilin 1 | -0.0123296 |
| AFAP1 | actin filament associated protein 1 | -0.0122915 |
| TAGLN2 | transgelin 2 | -0.0120426 |
| RUNX1 | runt-related transcription factor 1 | -0.0119078 |
| MTSS1 | metastasis suppressor 1 | -0.0117904 |
| STC1 | stanniocalcin 1 | -0.0116822 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.011594 |
| MYO9B | myosin IXB | -0.0114117 |
| HAS2 | hyaluronan synthase 2 | -0.0114088 |
| IL6 | interleukin 6 | -0.0113595 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0112604 |
| HDLBP | high density lipoprotein binding protein | -0.0111463 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0110902 |
| RAD21 | RAD21 homolog (S. pombe) | -0.010995 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0107972 |
| FSTL1 | follistatin-like 1 | -0.0107197 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0105424 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0104923 |
