LY2090314_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY2090314 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY2090314_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.325751
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.108752
SVIL supervillin 0.108319
IGFBP1 insulin-like growth factor binding protein 1 0.101841
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0756226
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0718608
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.070387
FNDC3B fibronectin type III domain containing 3B 0.0674491
APOB apolipoprotein B 0.0625154
RBM39 RNA binding motif protein 39 0.0586757
PAWR PRKC, apoptosis, WT1, regulator 0.0548817
JMJD1C jumonji domain containing 1C 0.0523194
FOXP1 forkhead box P1 0.052196
C3 complement component 3 0.0513551
ITGAV integrin, alpha V 0.0505722
KYNU kynureninase 0.0471138
TXNRD1 thioredoxin reductase 1 0.0450822
LCOR ligand dependent nuclear receptor corepressor 0.0446598
ELL2 elongation factor, RNA polymerase II, 2 0.0440796
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0429035
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0416033
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0411698
TRIO trio Rho guanine nucleotide exchange factor 0.0410756
NRIP1 nuclear receptor interacting protein 1 0.0377483
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0375488
SAMD4A sterile alpha motif domain containing 4A 0.037132
SIK3 SIK family kinase 3 0.0366609
DLC1 DLC1 Rho GTPase activating protein 0.0364778
GRB10 growth factor receptor-bound protein 10 0.0361648
MED13L mediator complex subunit 13-like 0.0361348
CRY1 cryptochrome circadian clock 1 0.0360508
BCL2L1 BCL2-like 1 0.0356424
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0353976
PUM2 pumilio RNA-binding family member 2 0.0352361
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0351301
ITCH itchy E3 ubiquitin protein ligase 0.0337676
PCBP2 poly(rC) binding protein 2 0.0337263
MRTFA myocardin related transcription factor A 0.0330139
CCL20 chemokine (C-C motif) ligand 20 0.0328137
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0327069
ZNF644 zinc finger protein 644 0.0321559
PTK2 protein tyrosine kinase 2 0.0320971
LIMS1 LIM and senescent cell antigen-like domains 1 0.0318435
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0318029
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0314202
ZFAND3 zinc finger, AN1-type domain 3 0.0313928
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0310305
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0307469
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0303933
MYO1B myosin IB 0.030043
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0300279
DSTN destrin (actin depolymerizing factor) 0.0292157
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0291901
ARL5B ADP-ribosylation factor-like 5B 0.0288099
AKAP13 A kinase (PRKA) anchor protein 13 0.0286903
AFDN afadin, adherens junction formation factor 0.0286037
ARHGAP9 Rho GTPase activating protein 9 0.0285515
USP47 ubiquitin specific peptidase 47 0.0282501
SEPTIN9 septin 9 0.0277374
MBNL1 muscleblind-like splicing regulator 1 0.0275653
JAK1 Janus kinase 1 0.0274388
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.027262
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0271796
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0269784
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0266284
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0262621
WAC WW domain containing adaptor with coiled-coil 0.0258322
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0254605
RAI14 retinoic acid induced 14 0.0254579
SFPQ splicing factor proline/glutamine-rich 0.0252986
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0252715
LMO7 LIM domain 7 0.0252154
CEMIP2 cell migration inducing hyaluronidase 2 0.0251845
GSPT1 G1 to S phase transition 1 0.0250611
FOXO1 forkhead box O1 0.0250044
YAP1 Yes-associated protein 1 0.0249237
SOS1 son of sevenless homolog 1 (Drosophila) 0.0248514
EEF2 eukaryotic translation elongation factor 2 0.0248018
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0247867
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0247546
KLF6 Kruppel-like factor 6 0.0246002
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.024239
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.024086
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0238183
NCKAP1 NCK-associated protein 1 0.0236131
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0236007
TF transferrin 0.0235641
FXR1 fragile X mental retardation, autosomal homolog 1 0.0235332
CUL3 cullin 3 0.023408
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0233486
FAM107B family with sequence similarity 107, member B 0.0231542
MAPK8 mitogen-activated protein kinase 8 0.0231374
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0230318
SNX9 sorting nexin 9 0.0229714
RBM6 RNA binding motif protein 6 0.0228769
CCNY cyclin Y 0.0225911
UBA6 ubiquitin-like modifier activating enzyme 6 0.0222281
DIAPH1 diaphanous-related formin 1 0.0221895
CORO1C coronin, actin binding protein, 1C 0.0221834
EPS8 epidermal growth factor receptor pathway substrate 8 0.0221327

decreased expression

Symbol Name Standardized Value
ENO1 enolase 1, (alpha) -0.120605
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.117108
AKAP12 A kinase (PRKA) anchor protein 12 -0.114546
TPT1 tumor protein, translationally-controlled 1 -0.110368
APOA2 apolipoprotein A-II -0.102021
MT2A metallothionein 2A -0.0967814
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0918819
PLIN2 perilipin 2 -0.0797103
RPL37A ribosomal protein L37a -0.0693679
RPS24 ribosomal protein S24 -0.0682369
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0663012
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0656771
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.064115
SLC38A2 solute carrier family 38, member 2 -0.060518
CP ceruloplasmin (ferroxidase) -0.0580035
RPS27A ribosomal protein S27a -0.0551904
TMSB10 thymosin beta 10 -0.0550621
RPS8 ribosomal protein S8 -0.0539947
ACTG1 actin gamma 1 -0.0515045
RPS12 ribosomal protein S12 -0.0474919
RPL31 ribosomal protein L31 -0.0466378
TM4SF1 transmembrane 4 L six family member 1 -0.0465401
RPL11 ribosomal protein L11 -0.0460193
NPAS2 neuronal PAS domain protein 2 -0.0458351
HMGA1 high mobility group AT-hook 1 -0.0453422
FTL ferritin, light polypeptide -0.0432534
GPC3 glypican 3 -0.0426313
GMDS GDP-mannose 4,6-dehydratase -0.0410063
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0403549
RPS6 ribosomal protein S6 -0.0401741
AHSG alpha-2-HS-glycoprotein -0.0361607
ASPH aspartate beta-hydroxylase -0.0358521
RPL35A ribosomal protein L35a -0.0351312
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0339395
RPS29 ribosomal protein S29 -0.033551
PGK1 phosphoglycerate kinase 1 -0.0334989
ZBTB20 zinc finger and BTB domain containing 20 -0.0334853
RPL23 ribosomal protein L23 -0.0334087
RPS10 ribosomal protein S10 -0.0326637
TPM4 tropomyosin 4 -0.0326058
NDRG1 N-myc downstream regulated 1 -0.0323736
RPLP1 ribosomal protein, large, P1 -0.0312133
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0310444
IFITM1 interferon induced transmembrane protein 1 -0.0300405
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0297264
PEG3 paternally expressed 3 -0.0294689
RPS23 ribosomal protein S23 -0.0287943
INTS6 integrator complex subunit 6 -0.0284344
RPS13 ribosomal protein S13 -0.0281827
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0281782
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.028146
RACK1 receptor for activated C kinase 1 -0.0280762
RPL10A ribosomal protein L10a -0.0280073
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0274563
RPL19 ribosomal protein L19 -0.0271781
ISG15 ISG15 ubiquitin-like modifier -0.0271619
RPL9 ribosomal protein L9 -0.0271229
RPL38 ribosomal protein L38 -0.0268955
RPS3 ribosomal protein S3 -0.0264669
PTPRF protein tyrosine phosphatase, receptor type, F -0.0264268
RPL12 ribosomal protein L12 -0.0256786
RPLP2 ribosomal protein, large, P2 -0.0256341
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0243391
RNF213 ring finger protein 213 -0.0242259
RPL28 ribosomal protein L28 -0.024077
NPR2 natriuretic peptide receptor 2 -0.0240281
GNAS GNAS complex locus -0.0238638
RPS16 ribosomal protein S16 -0.0234858
TMEM123 transmembrane protein 123 -0.0232787
ZMYND8 zinc finger, MYND-type containing 8 -0.0231412
LOC112694756 uncharaterized LOC112694756 -0.0230284
IFI6 interferon, alpha-inducible protein 6 -0.0229867
AHNAK AHNAK nucleoprotein -0.0228159
GPC6 glypican 6 -0.022456
UGP2 UDP-glucose pyrophosphorylase 2 -0.0223742
RPS11 ribosomal protein S11 -0.021981
PKM pyruvate kinase, muscle -0.0219532
CANX calnexin -0.0219399
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0218478
ZHX2 zinc fingers and homeoboxes 2 -0.0215785
S100A10 S100 calcium binding protein A10 -0.0213936
SQSTM1 sequestosome 1 -0.0213899
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0213523
RPS19 ribosomal protein S19 -0.0212991
RPS5 ribosomal protein S5 -0.0207634
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0205712
EGR1 early growth response 1 -0.01992
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.019146
CCDC146 coiled-coil domain containing 146 -0.0190957
LRRC23 leucine rich repeat containing 23 -0.018435
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0182826
IFITM3 interferon induced transmembrane protein 3 -0.0182814
RPL26 ribosomal protein L26 -0.0182032
RNASET2 ribonuclease T2 -0.0179027
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0178899
NAP1L1 nucleosome assembly protein 1-like 1 -0.0175795
VDAC1 voltage-dependent anion channel 1 -0.0175523
MT1E metallothionein 1E -0.0174713
STK17A serine/threonine kinase 17a -0.0174337
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0173451