LY2090314_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY2090314 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY2090314_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.162107
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0799448
AREG amphiregulin 0.0787997
FTL ferritin, light polypeptide 0.0700531
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0693818
GOLGA4 golgin A4 0.0629397
RPS12 ribosomal protein S12 0.0615387
EREG epiregulin 0.0556944
FTH1 ferritin, heavy polypeptide 1 0.0497678
EIF1 eukaryotic translation initiation factor 1 0.0486221
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0484344
RPS3 ribosomal protein S3 0.0469743
RPS8 ribosomal protein S8 0.0461581
RPS6 ribosomal protein S6 0.0419918
EEF2 eukaryotic translation elongation factor 2 0.0413248
RPL37A ribosomal protein L37a 0.0396147
RNF145 ring finger protein 145 0.0378503
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0377089
RPS2 ribosomal protein S2 0.036717
LDHA lactate dehydrogenase A 0.0361444
RPL12 ribosomal protein L12 0.0344156
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0341887
RPL11 ribosomal protein L11 0.0336991
YBX1 Y box binding protein 1 0.0320759
LMO7 LIM domain 7 0.0287672
RPS13 ribosomal protein S13 0.0281962
RPL13A ribosomal protein L13a 0.0276085
EXT1 exostosin glycosyltransferase 1 0.0275312
BRD2 bromodomain containing 2 0.0258481
COG5 component of oligomeric golgi complex 5 0.0256459
RPL9 ribosomal protein L9 0.0255993
CALR calreticulin 0.0249544
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0248378
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0247925
RPL7 ribosomal protein L7 0.0246204
RPL35A ribosomal protein L35a 0.0245366
TXNRD1 thioredoxin reductase 1 0.0244709
EPS8 epidermal growth factor receptor pathway substrate 8 0.0241731
RPL26 ribosomal protein L26 0.0240412
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.023775
RPS27 ribosomal protein S27 0.0237466
ZFAND3 zinc finger, AN1-type domain 3 0.023705
RBM39 RNA binding motif protein 39 0.0229777
RPS23 ribosomal protein S23 0.0229458
RPS29 ribosomal protein S29 0.0229307
RNF43 ring finger protein 43 0.0228091
EEF1G eukaryotic translation elongation factor 1 gamma 0.0222794
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0217893
RPLP2 ribosomal protein, large, P2 0.0217213
NEBL nebulette 0.021283
RPL36 ribosomal protein L36 0.0211489
RPS27A ribosomal protein S27a 0.0210682
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0208393
PNISR PNN-interacting serine/arginine-rich protein 0.0206424
VMP1 vacuole membrane protein 1 0.0204285
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0203059
PCBP2 poly(rC) binding protein 2 0.0202519
MON2 MON2 homolog (S. cerevisiae) 0.0202506
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0201861
B2M beta-2-microglobulin 0.0199936
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0198253
GDF15 growth differentiation factor 15 0.0192958
CSNK1A1 casein kinase 1, alpha 1 0.0192384
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0192218
PAPOLA poly(A) polymerase alpha 0.0190004
IARS1 isoleucyl-tRNA synthetase 1 0.0189458
ATF4 activating transcription factor 4 0.018939
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0189253
GARS1 glycyl-tRNA synthetase 1 0.0189082
PNN pinin, desmosome associated protein 0.0188387
YTHDC1 YTH domain containing 1 0.018737
KDM3A lysine (K)-specific demethylase 3A 0.0184119
DSCAM Down syndrome cell adhesion molecule 0.0179465
RPS4X ribosomal protein S4, X-linked 0.0178512
RACK1 receptor for activated C kinase 1 0.0178087
BCLAF1 BCL2-associated transcription factor 1 0.0173646
S100P S100 calcium binding protein P 0.0171352
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0171287
ACBD3 acyl-CoA binding domain containing 3 0.0170022
RSRC2 arginine/serine-rich coiled-coil 2 0.0169626
OGA O-GlcNAcase 0.0168751
RPL28 ribosomal protein L28 0.0168394
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0167384
COPA coatomer protein complex, subunit alpha 0.0164631
KMT2E lysine (K)-specific methyltransferase 2E 0.0163382
RPLP1 ribosomal protein, large, P1 0.0162915
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0161832
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0160897
GOLGB1 golgin B1 0.0160822
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0160624
RPS19 ribosomal protein S19 0.0159748
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0159592
AKAP9 A kinase (PRKA) anchor protein 9 0.0158768
TFG TRK-fused gene 0.0158553
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0157045
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0156997
SLC38A2 solute carrier family 38, member 2 0.0156894
RPL31 ribosomal protein L31 0.0156443
CUL3 cullin 3 0.015571
ANKRD11 ankyrin repeat domain 11 0.0155042

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.249545
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.125657
AHNAK AHNAK nucleoprotein -0.100004
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.094376
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0936151
GREB1L growth regulation by estrogen in breast cancer-like -0.0856014
NALF1 NALCN channel auxiliary factor 1 -0.0837384
TMSB10 thymosin beta 10 -0.0816913
PTMA prothymosin, alpha -0.0765621
FLNB filamin B, beta -0.0742368
ALCAM activated leukocyte cell adhesion molecule -0.0730345
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0672013
RNF217 ring finger protein 217 -0.065814
ANTXR2 anthrax toxin receptor 2 -0.0632907
PSD3 pleckstrin and Sec7 domain containing 3 -0.0592103
SLC35F3 solute carrier family 35, member F3 -0.055057
MAML3 mastermind-like 3 (Drosophila) -0.0546664
CEMIP cell migration inducing protein, hyaluronan binding -0.0520342
CALB1 calbindin 1, 28kDa -0.0519643
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0513334
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0495949
ONECUT3 one cut homeobox 3 -0.0492666
MUC17 mucin 17, cell surface associated -0.0480052
KRT18 keratin 18, type I -0.0476468
SMYD3 SET and MYND domain containing 3 -0.0469491
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0467519
FHIT fragile histidine triad -0.0465747
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0463239
CCSER1 coiled-coil serine-rich protein 1 -0.0446989
MAML2 mastermind-like 2 (Drosophila) -0.0442388
PATJ PATJ crumbs cell polarity complex component -0.0430859
DIAPH2 diaphanous-related formin 2 -0.0427305
FERMT1 fermitin family member 1 -0.0426187
S100A6 S100 calcium binding protein A6 -0.0424213
EHBP1 EH domain binding protein 1 -0.0408959
RIN2 Ras and Rab interactor 2 -0.0403022
RAD51B RAD51 paralog B -0.0399715
ITGA6 integrin, alpha 6 -0.0399047
ACTN4 actinin, alpha 4 -0.0398911
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0384234
DENND1A DENN/MADD domain containing 1A -0.0381637
SOX4 SRY (sex determining region Y)-box 4 -0.036764
PTPRK protein tyrosine phosphatase, receptor type, K -0.0359008
ARHGAP6 Rho GTPase activating protein 6 -0.035783
PDE4D phosphodiesterase 4D, cAMP-specific -0.0355952
SAMD5 sterile alpha motif domain containing 5 -0.0349795
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0344878
TPM4 tropomyosin 4 -0.0342464
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0315873
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0315612
GMDS GDP-mannose 4,6-dehydratase -0.0311142
EGFR epidermal growth factor receptor -0.0302894
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0300349
PRELID2 PRELI domain containing 2 -0.0299778
MSI2 musashi RNA-binding protein 2 -0.0297173
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0293402
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0291833
BACE2 beta-site APP-cleaving enzyme 2 -0.0290947
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0289435
ZBTB20 zinc finger and BTB domain containing 20 -0.0283568
TRIO trio Rho guanine nucleotide exchange factor -0.0281903
LSAMP limbic system-associated membrane protein -0.0281448
LPP LIM domain containing preferred translocation partner in lipoma -0.0281315
FRMD5 FERM domain containing 5 -0.0279863
MYO1D myosin ID -0.0278565
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0272135
FOXP1 forkhead box P1 -0.0269332
PTPRB protein tyrosine phosphatase, receptor type, B -0.02653
ITGB4 integrin, beta 4 -0.0263899
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0259316
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0256922
SBF2 SET binding factor 2 -0.0254434
TAS2R14 taste receptor, type 2, member 14 -0.0253475
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0250791
SPON1 spondin 1, extracellular matrix protein -0.025029
GPHN gephyrin -0.0247575
SH3D19 SH3 domain containing 19 -0.0246459
GRB10 growth factor receptor-bound protein 10 -0.0244074
INSR insulin receptor -0.0243799
DLG1 discs, large homolog 1 (Drosophila) -0.0243735
NRN1 neuritin 1 -0.0240638
PPARG peroxisome proliferator-activated receptor gamma -0.0235681
EZR ezrin -0.0230577
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0230334
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0229208
PTPRR protein tyrosine phosphatase, receptor type, R -0.0227998
FOSL1 FOS-like antigen 1 -0.0226798
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0222376
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0220682
GTF2IRD1 GTF2I repeat domain containing 1 -0.0220663
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) -0.0215913
CUX1 cut-like homeobox 1 -0.0215759
FAT1 FAT atypical cadherin 1 -0.0215187
PCDH9 protocadherin 9 -0.0214937
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0214903
HMGA1 high mobility group AT-hook 1 -0.0214188
KLK10 kallikrein-related peptidase 10 -0.0213425
TMEM123 transmembrane protein 123 -0.0212334
CCND1 cyclin D1 -0.0211065
VCAN versican -0.0210294