| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY2090314 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY2090314_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | 0.114192 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0952465 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0782847 |
| DST | dystonin | 0.0768197 |
| HLA-B | major histocompatibility complex, class I, B | 0.0569467 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0523968 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.047916 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.044585 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0407584 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0400188 |
| SP100 | SP100 nuclear antigen | 0.0388817 |
| RUNX1 | runt-related transcription factor 1 | 0.0379856 |
| CD44 | CD44 molecule (Indian blood group) | 0.0378403 |
| RPS6 | ribosomal protein S6 | 0.0359172 |
| PDE10A | phosphodiesterase 10A | 0.0356833 |
| RPL35A | ribosomal protein L35a | 0.0349757 |
| RPL12 | ribosomal protein L12 | 0.0345512 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0329891 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.03261 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0303367 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0287221 |
| CADM2 | cell adhesion molecule 2 | 0.0267692 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0265377 |
| RIGI | RNA sensor RIG-I | 0.0260353 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0247771 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0247515 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0247111 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0241887 |
| B2M | beta-2-microglobulin | 0.0241768 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0241679 |
| FTL | ferritin, light polypeptide | 0.0241297 |
| RPS12 | ribosomal protein S12 | 0.0240122 |
| SLK | STE20-like kinase | 0.0236861 |
| RPS8 | ribosomal protein S8 | 0.0236616 |
| RPL31 | ribosomal protein L31 | 0.0230375 |
| CAPRIN2 | caprin family member 2 | 0.0224611 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0216359 |
| DNER | delta/notch-like EGF repeat containing | 0.0215407 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0214174 |
| RPL26 | ribosomal protein L26 | 0.0208673 |
| KLF6 | Kruppel-like factor 6 | 0.020805 |
| RPS19 | ribosomal protein S19 | 0.0207843 |
| GOLGB1 | golgin B1 | 0.0206473 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0206419 |
| RAD51B | RAD51 paralog B | 0.0206084 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0205447 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0202131 |
| PLSCR1 | phospholipid scramblase 1 | 0.0200052 |
| MT2A | metallothionein 2A | 0.0199884 |
| PMP22 | peripheral myelin protein 22 | 0.0199169 |
| RPL37A | ribosomal protein L37a | 0.0198201 |
| RPL36 | ribosomal protein L36 | 0.0196386 |
| LDHA | lactate dehydrogenase A | 0.019547 |
| VCL | vinculin | 0.0192441 |
| MT1E | metallothionein 1E | 0.0190854 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.018827 |
| HOMER1 | homer scaffolding protein 1 | 0.0187752 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0186153 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0184153 |
| TRIM56 | tripartite motif containing 56 | 0.0183178 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0176639 |
| RPL38 | ribosomal protein L38 | 0.0171784 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0165192 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0164446 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.016443 |
| PRELID2 | PRELI domain containing 2 | 0.0164118 |
| RPS10 | ribosomal protein S10 | 0.0162037 |
| EPHA4 | EPH receptor A4 | 0.0162032 |
| RPL37 | ribosomal protein L37 | 0.015983 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.015741 |
| SQSTM1 | sequestosome 1 | 0.0154706 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0154599 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0154523 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0154188 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.015329 |
| RPL11 | ribosomal protein L11 | 0.0151863 |
| RPS2 | ribosomal protein S2 | 0.0151635 |
| RPS27 | ribosomal protein S27 | 0.0151401 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0150218 |
| RPL36A | ribosomal protein L36a | 0.0149359 |
| INTS6 | integrator complex subunit 6 | 0.0147328 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0143658 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0143173 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0143142 |
| RPL34 | ribosomal protein L34 | 0.0142901 |
| NEK10 | NIMA-related kinase 10 | 0.014229 |
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.0140986 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0140855 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0140486 |
| RPS13 | ribosomal protein S13 | 0.0140313 |
| VEGFC | vascular endothelial growth factor C | 0.0137235 |
| HLA-A | major histocompatibility complex, class I, A | 0.0133514 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0133288 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.013232 |
| AREG | amphiregulin | 0.0131909 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0131274 |
| F2R | coagulation factor II (thrombin) receptor | 0.0130571 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0130515 |
| RPL27 | ribosomal protein L27 | 0.0129556 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0129493 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0984819 |
| UBC | ubiquitin C | -0.09157 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0799862 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0666177 |
| TXNRD1 | thioredoxin reductase 1 | -0.0629999 |
| AHNAK | AHNAK nucleoprotein | -0.0628506 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0623508 |
| TMSB10 | thymosin beta 10 | -0.0592344 |
| RAI1 | retinoic acid induced 1 | -0.0575336 |
| VIM | vimentin | -0.0526887 |
| POTEF | POTE ankyrin domain family, member F | -0.0481181 |
| APP | amyloid beta (A4) precursor protein | -0.0478078 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0446434 |
| JUN | jun proto-oncogene | -0.0436809 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0428753 |
| PTMA | prothymosin, alpha | -0.0428091 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.041624 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0364379 |
| EZR | ezrin | -0.0362091 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0355226 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0353072 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0345459 |
| RPS27A | ribosomal protein S27a | -0.0340501 |
| RTN4 | reticulon 4 | -0.033937 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0337106 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0335539 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0328438 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0327332 |
| USP34 | ubiquitin specific peptidase 34 | -0.0314121 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0289608 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0282972 |
| FLNB | filamin B, beta | -0.0277573 |
| MCL1 | myeloid cell leukemia 1 | -0.0274759 |
| CANX | calnexin | -0.0272013 |
| MT1X | metallothionein 1X | -0.0266002 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0265732 |
| PCBP2 | poly(rC) binding protein 2 | -0.0264978 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0261797 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0254599 |
| ENO1 | enolase 1, (alpha) | -0.025096 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.024816 |
| OGA | O-GlcNAcase | -0.024683 |
| PGK1 | phosphoglycerate kinase 1 | -0.0234028 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0229558 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0227911 |
| POM121 | POM121 transmembrane nucleoporin | -0.0217585 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0216173 |
| RBM25 | RNA binding motif protein 25 | -0.0215251 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0215109 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.021154 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0209804 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0209609 |
| MATR3 | matrin 3 | -0.0209036 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0206158 |
| ECT2 | epithelial cell transforming 2 | -0.0205885 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0202835 |
| EMP1 | epithelial membrane protein 1 | -0.0200559 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0200514 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0200061 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0197331 |
| XPO1 | exportin 1 | -0.0191366 |
| ACTG1 | actin gamma 1 | -0.0191113 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | -0.0189361 |
| ANXA1 | annexin A1 | -0.0189144 |
| HMGB2 | high mobility group box 2 | -0.0187677 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0186118 |
| CENPF | centromere protein F, 350/400kDa | -0.0184976 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0183362 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0180952 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0180855 |
| SBF2 | SET binding factor 2 | -0.0180087 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0179316 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0177811 |
| SET | SET nuclear proto-oncogene | -0.0176859 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0176423 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0173329 |
| UPP1 | uridine phosphorylase 1 | -0.0173167 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0170259 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0170142 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0164199 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0163642 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0162989 |
| HDLBP | high density lipoprotein binding protein | -0.0162467 |
| NUP58 | nucleoporin 58 | -0.0160794 |
| RRM2 | ribonucleotide reductase M2 | -0.0159493 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0159339 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0158966 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0158752 |
| MKI67 | marker of proliferation Ki-67 | -0.0158598 |
| NBAS | neuroblastoma amplified sequence | -0.0157878 |
| DIAPH3 | diaphanous-related formin 3 | -0.0157498 |
| XPO6 | exportin 6 | -0.0156281 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0154035 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0153425 |
| TNPO1 | transportin 1 | -0.0153135 |
| SRPK2 | SRSF protein kinase 2 | -0.0152984 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.015273 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.0152721 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0152715 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0152079 |
