| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY2090314 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY2090314_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0738825 |
| TXNRD1 | thioredoxin reductase 1 | 0.0682843 |
| FAM13A | family with sequence similarity 13, member A | 0.0644673 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0457987 |
| NDRG1 | N-myc downstream regulated 1 | 0.042995 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0406372 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0370426 |
| TOP1 | topoisomerase (DNA) I | 0.0368216 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0363099 |
| TMEM165 | transmembrane protein 165 | 0.0356535 |
| NGLY1 | N-glycanase 1 | 0.0331366 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0329892 |
| GOLGB1 | golgin B1 | 0.0329279 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0319365 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0311673 |
| PCBP2 | poly(rC) binding protein 2 | 0.0303573 |
| OGA | O-GlcNAcase | 0.030161 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.029772 |
| PRRC2C | proline-rich coiled-coil 2C | 0.029316 |
| HYOU1 | hypoxia up-regulated 1 | 0.0290411 |
| CANX | calnexin | 0.0272318 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0262176 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0257591 |
| GOLGA4 | golgin A4 | 0.0256005 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0255236 |
| SRP54 | signal recognition particle 54kDa | 0.0250406 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0244975 |
| SPAG9 | sperm associated antigen 9 | 0.0243402 |
| HDLBP | high density lipoprotein binding protein | 0.0238565 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0234571 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0233659 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0233297 |
| TES | testin LIM domain protein | 0.0229121 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0227333 |
| TMF1 | TATA element modulatory factor 1 | 0.0225785 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0224064 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.022122 |
| ARRDC3 | arrestin domain containing 3 | 0.0220781 |
| PAPOLA | poly(A) polymerase alpha | 0.0220602 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0220469 |
| SUCO | SUN domain containing ossification factor | 0.021842 |
| MSN | moesin | 0.0217953 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.021791 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0217754 |
| NCKAP1 | NCK-associated protein 1 | 0.0217747 |
| LDHA | lactate dehydrogenase A | 0.021635 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0215255 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0211763 |
| RNF145 | ring finger protein 145 | 0.0209188 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0208173 |
| LMO7 | LIM domain 7 | 0.0204828 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0198584 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0198517 |
| SCEL | sciellin | 0.0197492 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0196586 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0193245 |
| COPA | coatomer protein complex, subunit alpha | 0.0190444 |
| YTHDC1 | YTH domain containing 1 | 0.0189923 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0188339 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.018613 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0184855 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0184151 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0180274 |
| DSPP | dentin sialophosphoprotein | 0.0176757 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0176657 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0176211 |
| SEC24A | SEC24 family member A | 0.0175373 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0175262 |
| ATP13A3 | ATPase type 13A3 | 0.0174612 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0174574 |
| POTEF | POTE ankyrin domain family, member F | 0.017202 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.017093 |
| TPD52 | tumor protein D52 | 0.0168294 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.016666 |
| CD163L1 | CD163 molecule-like 1 | 0.0165714 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0164565 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0164536 |
| SEPTIN2 | septin 2 | 0.0163894 |
| TPM3 | tropomyosin 3 | 0.0162556 |
| WASF2 | WAS protein family, member 2 | 0.0162132 |
| PTEN | phosphatase and tensin homolog | 0.0161875 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.016069 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0160022 |
| RBM39 | RNA binding motif protein 39 | 0.0159609 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0158542 |
| ZNF148 | zinc finger protein 148 | 0.0157144 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0156923 |
| CES1 | carboxylesterase 1 | 0.0156871 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0156619 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0155842 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0153352 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0153149 |
| SLK | STE20-like kinase | 0.0152886 |
| RNF149 | ring finger protein 149 | 0.0152876 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0152084 |
| HELZ | helicase with zinc finger | 0.0151724 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0150669 |
| TLK1 | tousled-like kinase 1 | 0.015014 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0149993 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.014932 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.113703 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0805954 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0801553 |
| EGFR | epidermal growth factor receptor | -0.0762244 |
| EFNA5 | ephrin-A5 | -0.0675009 |
| TMSB10 | thymosin beta 10 | -0.0672491 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0619481 |
| MT2A | metallothionein 2A | -0.0529373 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0510979 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0495199 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0462018 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0457806 |
| INTS6 | integrator complex subunit 6 | -0.0437224 |
| LAMC2 | laminin, gamma 2 | -0.0427523 |
| RNF213 | ring finger protein 213 | -0.0423598 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0413512 |
| AHNAK | AHNAK nucleoprotein | -0.040297 |
| VCL | vinculin | -0.0383563 |
| OSMR | oncostatin M receptor | -0.0382613 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0381282 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0372582 |
| NABP1 | nucleic acid binding protein 1 | -0.036934 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0352452 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0350327 |
| RPLP1 | ribosomal protein, large, P1 | -0.0334881 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0330553 |
| NCOA7 | nuclear receptor coactivator 7 | -0.032335 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0319366 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0313642 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.03025 |
| MYO1E | myosin IE | -0.029496 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0294122 |
| RPS24 | ribosomal protein S24 | -0.0289274 |
| RPL35A | ribosomal protein L35a | -0.0288934 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0281179 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0280449 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0266639 |
| CCND1 | cyclin D1 | -0.0266039 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0264139 |
| SP100 | SP100 nuclear antigen | -0.0254239 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0245848 |
| S100A10 | S100 calcium binding protein A10 | -0.023779 |
| GM2A | GM2 ganglioside activator | -0.0233791 |
| EGR1 | early growth response 1 | -0.0230205 |
| HLA-B | major histocompatibility complex, class I, B | -0.0230015 |
| CST3 | cystatin C | -0.0227733 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0222151 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0219197 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0205325 |
| MYO1D | myosin ID | -0.020395 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0202827 |
| RIGI | RNA sensor RIG-I | -0.02011 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0199569 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.019946 |
| KRT18 | keratin 18, type I | -0.0197745 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0197681 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0191771 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0189303 |
| IER3 | immediate early response 3 | -0.0186146 |
| RPL34 | ribosomal protein L34 | -0.0185544 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0185121 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0182967 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0180811 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0180667 |
| APP | amyloid beta (A4) precursor protein | -0.0178399 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0178257 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0178116 |
| ACTG1 | actin gamma 1 | -0.0172935 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0170773 |
| HOMER1 | homer scaffolding protein 1 | -0.0170495 |
| RPL30 | ribosomal protein L30 | -0.0169288 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0168925 |
| RAD51B | RAD51 paralog B | -0.0168469 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0168078 |
| KRT7 | keratin 7, type II | -0.0167554 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0165655 |
| SUMF1 | sulfatase modifying factor 1 | -0.0163011 |
| PLSCR1 | phospholipid scramblase 1 | -0.016179 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0156956 |
| RPS27A | ribosomal protein S27a | -0.0155918 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.015461 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0152317 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0151548 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0150735 |
| TRIM56 | tripartite motif containing 56 | -0.0150549 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.014756 |
| CP | ceruloplasmin (ferroxidase) | -0.0147529 |
| RPS23 | ribosomal protein S23 | -0.0147144 |
| MX1 | MX dynamin-like GTPase 1 | -0.0146758 |
| RPS25 | ribosomal protein S25 | -0.0146201 |
| RPL31 | ribosomal protein L31 | -0.0145647 |
| KYNU | kynureninase | -0.0145081 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0144343 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0140912 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0140371 |
| TNS3 | tensin 3 | -0.0140077 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0138325 |
| SMAD3 | SMAD family member 3 | -0.0138175 |
| RPL23 | ribosomal protein L23 | -0.0137623 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0137065 |
