| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY2090314 perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LY2090314_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.102494 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0827365 |
| FTL | ferritin, light polypeptide | 0.0747321 |
| TMSB10 | thymosin beta 10 | 0.0738797 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0721094 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0671898 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0664987 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0619007 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0544617 |
| FMNL2 | formin-like 2 | 0.0538138 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0504465 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0503953 |
| RBM39 | RNA binding motif protein 39 | 0.0499932 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0465751 |
| WAC | WW domain containing adaptor with coiled-coil | 0.04582 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0440459 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0439937 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0436519 |
| RBM25 | RNA binding motif protein 25 | 0.0427645 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0419594 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0410219 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0409079 |
| COPA | coatomer protein complex, subunit alpha | 0.0397148 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0387545 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0380023 |
| RPLP1 | ribosomal protein, large, P1 | 0.037993 |
| RPL23 | ribosomal protein L23 | 0.0363212 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0360091 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0352219 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.034926 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.034034 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0333871 |
| GOLGA4 | golgin A4 | 0.0330665 |
| SLMAP | sarcolemma associated protein | 0.0330579 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0327002 |
| RPS19 | ribosomal protein S19 | 0.0309917 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0309208 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0308556 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0308553 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0305318 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0302647 |
| NUMB | numb homolog (Drosophila) | 0.0299194 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0288789 |
| CFDP1 | craniofacial development protein 1 | 0.0288477 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0285981 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0285838 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0279897 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0274768 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0274182 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.0267076 |
| CMIP | c-Maf inducing protein | 0.0265375 |
| PHIP | pleckstrin homology domain interacting protein | 0.0263094 |
| CUL3 | cullin 3 | 0.0262024 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0261377 |
| SNX14 | sorting nexin 14 | 0.0255709 |
| VRK2 | vaccinia related kinase 2 | 0.0255493 |
| RPL36 | ribosomal protein L36 | 0.0254915 |
| RPL19 | ribosomal protein L19 | 0.0254457 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0252424 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.025001 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | 0.0246307 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0245646 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0241704 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0240639 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0238504 |
| BMP6 | bone morphogenetic protein 6 | 0.0236796 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0235953 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0233337 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.023207 |
| RNF145 | ring finger protein 145 | 0.0231101 |
| PARD3 | par-3 family cell polarity regulator | 0.0230977 |
| B2M | beta-2-microglobulin | 0.0229633 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0229378 |
| GLG1 | golgi glycoprotein 1 | 0.0228161 |
| TPD52 | tumor protein D52 | 0.0227404 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0225217 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0224994 |
| RPS21 | ribosomal protein S21 | 0.0224779 |
| MYO1E | myosin IE | 0.0223421 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0223106 |
| FAM107B | family with sequence similarity 107, member B | 0.0223105 |
| SRP54 | signal recognition particle 54kDa | 0.0222862 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.022177 |
| CCNY | cyclin Y | 0.0221736 |
| CBFB | core-binding factor, beta subunit | 0.0221482 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0221099 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0220561 |
| KIAA0319 | KIAA0319 | 0.0219044 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0218131 |
| NEMF | nuclear export mediator factor | 0.0214595 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0212444 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0211574 |
| ATXN1 | ataxin 1 | 0.0209577 |
| COG5 | component of oligomeric golgi complex 5 | 0.0208932 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0205493 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0204074 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0203435 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0202833 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0202159 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0201773 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.127576 |
| GRAMD1B | GRAM domain containing 1B | -0.0888468 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0751589 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0724997 |
| EGR1 | early growth response 1 | -0.0712771 |
| HDAC9 | histone deacetylase 9 | -0.0677197 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0620979 |
| ACTG1 | actin gamma 1 | -0.0559152 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0547684 |
| MCL1 | myeloid cell leukemia 1 | -0.0507129 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0444412 |
| PKM | pyruvate kinase, muscle | -0.0439202 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0410952 |
| BICC1 | BicC family RNA binding protein 1 | -0.0388001 |
| ENO1 | enolase 1, (alpha) | -0.0356149 |
| LDHA | lactate dehydrogenase A | -0.0343693 |
| RPL4 | ribosomal protein L4 | -0.0340545 |
| VIM | vimentin | -0.0334974 |
| WWOX | WW domain containing oxidoreductase | -0.0331972 |
| EFNA5 | ephrin-A5 | -0.0316981 |
| NAV3 | neuron navigator 3 | -0.0316044 |
| NEGR1 | neuronal growth regulator 1 | -0.0314474 |
| AK1 | adenylate kinase 1 | -0.0303322 |
| SQSTM1 | sequestosome 1 | -0.0302533 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0300019 |
| IGF2 | insulin-like growth factor 2 | -0.0297938 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0294032 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0292375 |
| DST | dystonin | -0.0288869 |
| SVIL | supervillin | -0.0280419 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0278444 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0276533 |
| AHR | aryl hydrocarbon receptor | -0.0274456 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0273244 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0272097 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0268566 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0248294 |
| POTEF | POTE ankyrin domain family, member F | -0.024815 |
| FGB | fibrinogen beta chain | -0.0247854 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0244115 |
| ZNF804A | zinc finger protein 804A | -0.0243843 |
| MAP1B | microtubule-associated protein 1B | -0.023934 |
| NNMT | nicotinamide N-methyltransferase | -0.0237394 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0235836 |
| TPM4 | tropomyosin 4 | -0.0234696 |
| NTN4 | netrin 4 | -0.0232484 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0229974 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0229756 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.022574 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0223507 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0223137 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0220263 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0218637 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0211327 |
| THBS1 | thrombospondin 1 | -0.0208887 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0208043 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0207351 |
| ASPH | aspartate beta-hydroxylase | -0.0205049 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0204068 |
| ANXA2 | annexin A2 | -0.0203621 |
| NABP1 | nucleic acid binding protein 1 | -0.0201836 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0200084 |
| FGG | fibrinogen gamma chain | -0.0193164 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0192201 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0190888 |
| VMP1 | vacuole membrane protein 1 | -0.0189852 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0189694 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.018823 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.018724 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0184568 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0177339 |
| RSPO3 | R-spondin 3 | -0.0177142 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.017496 |
| OSMR | oncostatin M receptor | -0.0173977 |
| FSTL5 | follistatin-like 5 | -0.0169498 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0166735 |
| TMEM123 | transmembrane protein 123 | -0.0161064 |
| CBX5 | chromobox homolog 5 | -0.0160893 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0157207 |
| DENND4A | DENN/MADD domain containing 4A | -0.0155943 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0154546 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0154165 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0152059 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0151447 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0150212 |
| MKI67 | marker of proliferation Ki-67 | -0.0149409 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0149405 |
| FGA | fibrinogen alpha chain | -0.0147762 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.0144303 |
| JUN | jun proto-oncogene | -0.0143857 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0143545 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0143219 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0141201 |
| CLTC | clathrin, heavy chain (Hc) | -0.0140467 |
| SRGN | serglycin | -0.0140381 |
| RNF213 | ring finger protein 213 | -0.0139278 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0138253 |
| WDR43 | WD repeat domain 43 | -0.0137018 |
| AHNAK | AHNAK nucleoprotein | -0.0136673 |
| TDP2 | tyrosyl-DNA phosphodiesterase 2 | -0.0136671 |
