| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LY2090314 perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LY2090314_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0887888 |
| GRB10 | growth factor receptor-bound protein 10 | 0.076205 |
| LMO7 | LIM domain 7 | 0.0717065 |
| B2M | beta-2-microglobulin | 0.0716764 |
| LAMC2 | laminin, gamma 2 | 0.0656571 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0609498 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0605596 |
| CTBP2 | C-terminal binding protein 2 | 0.0580304 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0544615 |
| UBC | ubiquitin C | 0.0525323 |
| FN1 | fibronectin 1 | 0.0500539 |
| RBM47 | RNA binding motif protein 47 | 0.0496107 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0481418 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0471463 |
| SVIL | supervillin | 0.046917 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0455111 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0452875 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0452144 |
| TXNRD1 | thioredoxin reductase 1 | 0.045156 |
| TPR | translocated promoter region, nuclear basket protein | 0.0446947 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0439508 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0434549 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0429298 |
| FAM13A | family with sequence similarity 13, member A | 0.0425234 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0408888 |
| EGFR | epidermal growth factor receptor | 0.0408022 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.040365 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0402573 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0400727 |
| FUS | FUS RNA binding protein | 0.0395026 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0391379 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0385943 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0378123 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0373138 |
| CDK13 | cyclin-dependent kinase 13 | 0.0371443 |
| ANKRD28 | ankyrin repeat domain 28 | 0.036944 |
| FHIT | fragile histidine triad | 0.0364619 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0362681 |
| PCBP3 | poly(rC) binding protein 3 | 0.0350135 |
| MYO6 | myosin VI | 0.0349381 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0346318 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0344761 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0344087 |
| RRBP1 | ribosome binding protein 1 | 0.0341784 |
| TJP1 | tight junction protein 1 | 0.034165 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.033962 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0338928 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0338759 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0337401 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0337303 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0335907 |
| NEBL | nebulette | 0.0329523 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0328935 |
| ABHD17C | abhydrolase domain containing 17C | 0.0327241 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0326934 |
| TMSB10 | thymosin beta 10 | 0.0324672 |
| SETD2 | SET domain containing 2 | 0.0320642 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0320138 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0319716 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0319602 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0317062 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0315318 |
| SAMD5 | sterile alpha motif domain containing 5 | 0.0313281 |
| GOLGA4 | golgin A4 | 0.03123 |
| XPO1 | exportin 1 | 0.0310384 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0310265 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0309384 |
| MYO5B | myosin VB | 0.0308765 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0307423 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.030631 |
| GSK3B | glycogen synthase kinase 3 beta | 0.030581 |
| MRTFA | myocardin related transcription factor A | 0.0303447 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0303198 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0301618 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.030136 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0297647 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.029318 |
| SLK | STE20-like kinase | 0.0293153 |
| MYOF | myoferlin | 0.0292258 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0289782 |
| BBX | bobby sox homolog (Drosophila) | 0.0289714 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0287654 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0287046 |
| MUC16 | mucin 16, cell surface associated | 0.02866 |
| YBX3 | Y box binding protein 3 | 0.0284212 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0282464 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0281482 |
| RPS17 | ribosomal protein S17 | 0.0280289 |
| PTK2 | protein tyrosine kinase 2 | 0.0279491 |
| RPL7A | ribosomal protein L7a | 0.027802 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0277574 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0275332 |
| PDE8A | phosphodiesterase 8A | 0.0274044 |
| USP53 | ubiquitin specific peptidase 53 | 0.027221 |
| RPL15 | ribosomal protein L15 | 0.0272101 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0272007 |
| SFSWAP | splicing factor, suppressor of white-apricot family | 0.0270604 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0269048 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0268309 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0268264 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.301446 |
| NDRG1 | N-myc downstream regulated 1 | -0.20374 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.128511 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.120535 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.120401 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.107633 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.092982 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0870913 |
| IGF2 | insulin-like growth factor 2 | -0.0846495 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0838047 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0797229 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0780157 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0698112 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0692978 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0605701 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0602504 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0590069 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0547884 |
| ANXA1 | annexin A1 | -0.0541137 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0502542 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0501577 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0483357 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.046171 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0445439 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0426836 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0416863 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0411894 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0407134 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0405725 |
| RTN4 | reticulon 4 | -0.0386707 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0382801 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0382384 |
| SPAG9 | sperm associated antigen 9 | -0.0378029 |
| PARD3 | par-3 family cell polarity regulator | -0.0374893 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0372578 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0369168 |
| JMJD1C | jumonji domain containing 1C | -0.0368317 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0365072 |
| SDC4 | syndecan 4 | -0.0363992 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0363504 |
| MCL1 | myeloid cell leukemia 1 | -0.035816 |
| OSMR | oncostatin M receptor | -0.0357586 |
| ENO1 | enolase 1, (alpha) | -0.0351656 |
| VCL | vinculin | -0.0348044 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0346195 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.034485 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0344324 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0343423 |
| MORF4L2 | mortality factor 4 like 2 | -0.0342218 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0339761 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0338357 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0329799 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0328597 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0324246 |
| RAD51B | RAD51 paralog B | -0.0322871 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.032268 |
| OGA | O-GlcNAcase | -0.0315022 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0313931 |
| KYNU | kynureninase | -0.0313771 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0310489 |
| USP34 | ubiquitin specific peptidase 34 | -0.0309743 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0304488 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0304305 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0300398 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0298058 |
| FMN1 | formin 1 | -0.0296801 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0295968 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0294792 |
| RPS24 | ribosomal protein S24 | -0.0293566 |
| ABI1 | abl-interactor 1 | -0.0293424 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0290172 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0289111 |
| ANO6 | anoctamin 6 | -0.0288186 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.028494 |
| MAP4 | microtubule-associated protein 4 | -0.0283634 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0282854 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0278798 |
| RPL4 | ribosomal protein L4 | -0.027686 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0275213 |
| SBF2 | SET binding factor 2 | -0.0272276 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0271409 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0256953 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0256614 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0256434 |
| EHBP1 | EH domain binding protein 1 | -0.0255268 |
| ETNK1 | ethanolamine kinase 1 | -0.0254245 |
| MXD1 | MAX dimerization protein 1 | -0.0249633 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0248841 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0245361 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0245062 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.024417 |
| LAMB3 | laminin, beta 3 | -0.0242785 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0242393 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0240303 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0240195 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0239797 |
| YBX1 | Y box binding protein 1 | -0.0238832 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0238331 |
| CANX | calnexin | -0.0237844 |
| RPS6 | ribosomal protein S6 | -0.0236793 |
